Endogenous plastic composite material in the Alzheimer’s brain
Accumulation of amyloid β (Aβ) peptide in brain is the hallmark of Alzheimer’s disease (AD). The resulting plaques though fibrous in nature may also consist of additional structures currently poorly defined. We hypothesize that plastic composite material contributes to plaque formation. This materia...
Gespeichert in:
| Veröffentlicht in: | Medical hypotheses 2006, Vol.67 (3), p.467-470 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 470 |
|---|---|
| container_issue | 3 |
| container_start_page | 467 |
| container_title | Medical hypotheses |
| container_volume | 67 |
| creator | Seidler, N.W. Craig, H.D. Squire, T.J. |
| description | Accumulation of amyloid β (Aβ) peptide in brain is the hallmark of Alzheimer’s disease (AD). The resulting plaques though fibrous in nature may also consist of additional structures currently poorly defined. We hypothesize that plastic composite material contributes to plaque formation. This material is organized by polymers of acrolein, which is an oxidized lipid fragment found in AD. Acrolein, a 3-carbon compound, contains a carbonyl and a vinyl group that participate in polymerization via fundamental latex chemistry. The redox and surfactant properties of Aβ allow it to catalyze the polymerization of acrolein. We previously reported observations of thin plastic fragments of Aβ-polyacrolein. The current paper outlines the proposed steps in forming these plastic fragments. Endogenous plastic composite material may significantly contribute to the pathogenesis of AD. |
| doi_str_mv | 10.1016/j.mehy.2006.02.038 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_68605023</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0306987706001599</els_id><sourcerecordid>68605023</sourcerecordid><originalsourceid>FETCH-LOGICAL-c354t-2c346fbafe1eb0907cbc4de53a550fa16428b4fa0267828e1888008929a923383</originalsourceid><addsrcrecordid>eNp9kL1OwzAQgC0EoqXwAgwoE1vC2U5sR2IAVeVHqsQCs-U4F-oqP8VOkcrEa_B6PAkprcTGdMt3n-4-Qs4pJBSouFomDS42CQMQCbAEuDogY5pxFjMp5SEZAwcR50rKETkJYQkAecrVMRlRIaTKpRiTm1lbdq_YdusQrWoTemcj2zWrLrgeo8b06J2pI9dG_QKj2_pjga5B__35FaLCG9eekqPK1AHP9nNCXu5mz9OHeP50_zi9nceWZ2kfM8tTURWmQooF5CBtYdMSM26yDCpDRcpUkVYG2HAZU0iVUgAqZ7nJGeeKT8jlzrvy3dsaQ68bFyzWtWlxOF4LJSCDAZ0QtgOt70LwWOmVd43xG01Bb7vppd5209tuGpiGX_vF3r4uGiz_VvahBuB6B-Dw47tDr4N12FosnUfb67Jz__l_AH7HfzA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>68605023</pqid></control><display><type>article</type><title>Endogenous plastic composite material in the Alzheimer’s brain</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Seidler, N.W. ; Craig, H.D. ; Squire, T.J.</creator><creatorcontrib>Seidler, N.W. ; Craig, H.D. ; Squire, T.J.</creatorcontrib><description>Accumulation of amyloid β (Aβ) peptide in brain is the hallmark of Alzheimer’s disease (AD). The resulting plaques though fibrous in nature may also consist of additional structures currently poorly defined. We hypothesize that plastic composite material contributes to plaque formation. This material is organized by polymers of acrolein, which is an oxidized lipid fragment found in AD. Acrolein, a 3-carbon compound, contains a carbonyl and a vinyl group that participate in polymerization via fundamental latex chemistry. The redox and surfactant properties of Aβ allow it to catalyze the polymerization of acrolein. We previously reported observations of thin plastic fragments of Aβ-polyacrolein. The current paper outlines the proposed steps in forming these plastic fragments. Endogenous plastic composite material may significantly contribute to the pathogenesis of AD.</description><identifier>ISSN: 0306-9877</identifier><identifier>EISSN: 1532-2777</identifier><identifier>DOI: 10.1016/j.mehy.2006.02.038</identifier><identifier>PMID: 16678976</identifier><language>eng</language><publisher>United States: Elsevier Ltd</publisher><subject>Acrolein - chemistry ; Alzheimer Disease ; Amyloid - chemistry ; Biopolymers - chemistry ; Brain Chemistry ; Humans ; Models, Biological ; Oxidation-Reduction ; Plaque, Amyloid - chemistry ; Plastics - chemistry ; Polymers - chemistry</subject><ispartof>Medical hypotheses, 2006, Vol.67 (3), p.467-470</ispartof><rights>2006 Elsevier Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c354t-2c346fbafe1eb0907cbc4de53a550fa16428b4fa0267828e1888008929a923383</citedby><cites>FETCH-LOGICAL-c354t-2c346fbafe1eb0907cbc4de53a550fa16428b4fa0267828e1888008929a923383</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.mehy.2006.02.038$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,4025,27925,27926,27927,45997</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16678976$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Seidler, N.W.</creatorcontrib><creatorcontrib>Craig, H.D.</creatorcontrib><creatorcontrib>Squire, T.J.</creatorcontrib><title>Endogenous plastic composite material in the Alzheimer’s brain</title><title>Medical hypotheses</title><addtitle>Med Hypotheses</addtitle><description>Accumulation of amyloid β (Aβ) peptide in brain is the hallmark of Alzheimer’s disease (AD). The resulting plaques though fibrous in nature may also consist of additional structures currently poorly defined. We hypothesize that plastic composite material contributes to plaque formation. This material is organized by polymers of acrolein, which is an oxidized lipid fragment found in AD. Acrolein, a 3-carbon compound, contains a carbonyl and a vinyl group that participate in polymerization via fundamental latex chemistry. The redox and surfactant properties of Aβ allow it to catalyze the polymerization of acrolein. We previously reported observations of thin plastic fragments of Aβ-polyacrolein. The current paper outlines the proposed steps in forming these plastic fragments. Endogenous plastic composite material may significantly contribute to the pathogenesis of AD.</description><subject>Acrolein - chemistry</subject><subject>Alzheimer Disease</subject><subject>Amyloid - chemistry</subject><subject>Biopolymers - chemistry</subject><subject>Brain Chemistry</subject><subject>Humans</subject><subject>Models, Biological</subject><subject>Oxidation-Reduction</subject><subject>Plaque, Amyloid - chemistry</subject><subject>Plastics - chemistry</subject><subject>Polymers - chemistry</subject><issn>0306-9877</issn><issn>1532-2777</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kL1OwzAQgC0EoqXwAgwoE1vC2U5sR2IAVeVHqsQCs-U4F-oqP8VOkcrEa_B6PAkprcTGdMt3n-4-Qs4pJBSouFomDS42CQMQCbAEuDogY5pxFjMp5SEZAwcR50rKETkJYQkAecrVMRlRIaTKpRiTm1lbdq_YdusQrWoTemcj2zWrLrgeo8b06J2pI9dG_QKj2_pjga5B__35FaLCG9eekqPK1AHP9nNCXu5mz9OHeP50_zi9nceWZ2kfM8tTURWmQooF5CBtYdMSM26yDCpDRcpUkVYG2HAZU0iVUgAqZ7nJGeeKT8jlzrvy3dsaQ68bFyzWtWlxOF4LJSCDAZ0QtgOt70LwWOmVd43xG01Bb7vppd5209tuGpiGX_vF3r4uGiz_VvahBuB6B-Dw47tDr4N12FosnUfb67Jz__l_AH7HfzA</recordid><startdate>2006</startdate><enddate>2006</enddate><creator>Seidler, N.W.</creator><creator>Craig, H.D.</creator><creator>Squire, T.J.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2006</creationdate><title>Endogenous plastic composite material in the Alzheimer’s brain</title><author>Seidler, N.W. ; Craig, H.D. ; Squire, T.J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c354t-2c346fbafe1eb0907cbc4de53a550fa16428b4fa0267828e1888008929a923383</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Acrolein - chemistry</topic><topic>Alzheimer Disease</topic><topic>Amyloid - chemistry</topic><topic>Biopolymers - chemistry</topic><topic>Brain Chemistry</topic><topic>Humans</topic><topic>Models, Biological</topic><topic>Oxidation-Reduction</topic><topic>Plaque, Amyloid - chemistry</topic><topic>Plastics - chemistry</topic><topic>Polymers - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Seidler, N.W.</creatorcontrib><creatorcontrib>Craig, H.D.</creatorcontrib><creatorcontrib>Squire, T.J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Medical hypotheses</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Seidler, N.W.</au><au>Craig, H.D.</au><au>Squire, T.J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Endogenous plastic composite material in the Alzheimer’s brain</atitle><jtitle>Medical hypotheses</jtitle><addtitle>Med Hypotheses</addtitle><date>2006</date><risdate>2006</risdate><volume>67</volume><issue>3</issue><spage>467</spage><epage>470</epage><pages>467-470</pages><issn>0306-9877</issn><eissn>1532-2777</eissn><abstract>Accumulation of amyloid β (Aβ) peptide in brain is the hallmark of Alzheimer’s disease (AD). The resulting plaques though fibrous in nature may also consist of additional structures currently poorly defined. We hypothesize that plastic composite material contributes to plaque formation. This material is organized by polymers of acrolein, which is an oxidized lipid fragment found in AD. Acrolein, a 3-carbon compound, contains a carbonyl and a vinyl group that participate in polymerization via fundamental latex chemistry. The redox and surfactant properties of Aβ allow it to catalyze the polymerization of acrolein. We previously reported observations of thin plastic fragments of Aβ-polyacrolein. The current paper outlines the proposed steps in forming these plastic fragments. Endogenous plastic composite material may significantly contribute to the pathogenesis of AD.</abstract><cop>United States</cop><pub>Elsevier Ltd</pub><pmid>16678976</pmid><doi>10.1016/j.mehy.2006.02.038</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0306-9877 |
| ispartof | Medical hypotheses, 2006, Vol.67 (3), p.467-470 |
| issn | 0306-9877 1532-2777 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68605023 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Acrolein - chemistry Alzheimer Disease Amyloid - chemistry Biopolymers - chemistry Brain Chemistry Humans Models, Biological Oxidation-Reduction Plaque, Amyloid - chemistry Plastics - chemistry Polymers - chemistry |
| title | Endogenous plastic composite material in the Alzheimer’s brain |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-17T16%3A00%3A45IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Endogenous%20plastic%20composite%20material%20in%20the%20Alzheimer%E2%80%99s%20brain&rft.jtitle=Medical%20hypotheses&rft.au=Seidler,%20N.W.&rft.date=2006&rft.volume=67&rft.issue=3&rft.spage=467&rft.epage=470&rft.pages=467-470&rft.issn=0306-9877&rft.eissn=1532-2777&rft_id=info:doi/10.1016/j.mehy.2006.02.038&rft_dat=%3Cproquest_cross%3E68605023%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=68605023&rft_id=info:pmid/16678976&rft_els_id=S0306987706001599&rfr_iscdi=true |