Amperometric Sensor for the Determination of Ascorbic Acid Based on Cobalt Hexacyanoferrate Modified Electrode Fabricated through a New Route
A new approach was attempted to prepare a chemically modified electrode using Cobalt hexacyanoferrate (CoHCF) as the redox mediator and to study its stability and electrocatalytic activity for ascorbic acid (AA) oxidation. The basic principle underlying the electrode modification is the coordination...
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| Veröffentlicht in: | Chemical & Pharmaceutical Bulletin 2006, Vol.54(7), pp.963-967 |
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| creator | Kumar, Sellappan Senthil Narayanan, Sangilimuthu Sriman |
| description | A new approach was attempted to prepare a chemically modified electrode using Cobalt hexacyanoferrate (CoHCF) as the redox mediator and to study its stability and electrocatalytic activity for ascorbic acid (AA) oxidation. The basic principle underlying the electrode modification is the coordination of cobalt ion with the amino nitrogen of aniline adsorbed on the surface of a graphite rod. This surface was subsequently derivatized with ferrocyanide to get CoHCF film on the electrode surface. The CoHCF modified electrode as prepared above was characterized using cyclic voltammetry. The effect of scan rate, supporting electrolyte and pH of the medium on the performance of the modified electrode was investigated. The CoHCF modified electrode exhibited good electrocatalytic activity towards the oxidation of ascorbic acid and gave a linear response from 5.52×10−5 M to 3.23×10−2 M with a correlation coefficient of 0.9929. The detection limit was found to be 3.33×10−5 M. Hydrodynamic voltammetry and chronoamperometry studies for the oxidation of ascorbic acid were also carried out. The electrode was highly stable and exhibited good reproducibility. This modified electrode was also applied for the determination of ascorbic acid in commercial samples. |
| doi_str_mv | 10.1248/cpb.54.963 |
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The basic principle underlying the electrode modification is the coordination of cobalt ion with the amino nitrogen of aniline adsorbed on the surface of a graphite rod. This surface was subsequently derivatized with ferrocyanide to get CoHCF film on the electrode surface. The CoHCF modified electrode as prepared above was characterized using cyclic voltammetry. The effect of scan rate, supporting electrolyte and pH of the medium on the performance of the modified electrode was investigated. The CoHCF modified electrode exhibited good electrocatalytic activity towards the oxidation of ascorbic acid and gave a linear response from 5.52×10−5 M to 3.23×10−2 M with a correlation coefficient of 0.9929. The detection limit was found to be 3.33×10−5 M. Hydrodynamic voltammetry and chronoamperometry studies for the oxidation of ascorbic acid were also carried out. The electrode was highly stable and exhibited good reproducibility. This modified electrode was also applied for the determination of ascorbic acid in commercial samples.</description><identifier>ISSN: 0009-2363</identifier><identifier>EISSN: 1347-5223</identifier><identifier>DOI: 10.1248/cpb.54.963</identifier><identifier>PMID: 16819212</identifier><language>eng</language><publisher>Japan: The Pharmaceutical Society of Japan</publisher><subject>aniline ; ascorbic acid ; Ascorbic Acid - analysis ; Ascorbic Acid - chemistry ; cobalt hexacyanoferrate ; cyclic voltammetry ; Electrochemistry - instrumentation ; Electrodes ; Ferrocyanides - chemistry ; Indicators and Reagents ; Oxidation-Reduction ; Reproducibility of Results</subject><ispartof>Chemical and Pharmaceutical Bulletin, 2006, Vol.54(7), pp.963-967</ispartof><rights>2006 The Pharmaceutical Society of Japan</rights><rights>Copyright Japan Science and Technology Agency 2006</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c661t-2e375b9680881e4742687652c9490aad61d015ba976b4dde543b2b092578d1d3</citedby><cites>FETCH-LOGICAL-c661t-2e375b9680881e4742687652c9490aad61d015ba976b4dde543b2b092578d1d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16819212$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kumar, Sellappan Senthil</creatorcontrib><creatorcontrib>Narayanan, Sangilimuthu Sriman</creatorcontrib><creatorcontrib>Department of Analytical Chemistry</creatorcontrib><creatorcontrib>School of Chemical Sciences</creatorcontrib><creatorcontrib>University of Madras</creatorcontrib><title>Amperometric Sensor for the Determination of Ascorbic Acid Based on Cobalt Hexacyanoferrate Modified Electrode Fabricated through a New Route</title><title>Chemical & Pharmaceutical Bulletin</title><addtitle>Chem. Pharm. Bull.</addtitle><description>A new approach was attempted to prepare a chemically modified electrode using Cobalt hexacyanoferrate (CoHCF) as the redox mediator and to study its stability and electrocatalytic activity for ascorbic acid (AA) oxidation. The basic principle underlying the electrode modification is the coordination of cobalt ion with the amino nitrogen of aniline adsorbed on the surface of a graphite rod. This surface was subsequently derivatized with ferrocyanide to get CoHCF film on the electrode surface. The CoHCF modified electrode as prepared above was characterized using cyclic voltammetry. The effect of scan rate, supporting electrolyte and pH of the medium on the performance of the modified electrode was investigated. The CoHCF modified electrode exhibited good electrocatalytic activity towards the oxidation of ascorbic acid and gave a linear response from 5.52×10−5 M to 3.23×10−2 M with a correlation coefficient of 0.9929. The detection limit was found to be 3.33×10−5 M. Hydrodynamic voltammetry and chronoamperometry studies for the oxidation of ascorbic acid were also carried out. The electrode was highly stable and exhibited good reproducibility. This modified electrode was also applied for the determination of ascorbic acid in commercial samples.</description><subject>aniline</subject><subject>ascorbic acid</subject><subject>Ascorbic Acid - analysis</subject><subject>Ascorbic Acid - chemistry</subject><subject>cobalt hexacyanoferrate</subject><subject>cyclic voltammetry</subject><subject>Electrochemistry - instrumentation</subject><subject>Electrodes</subject><subject>Ferrocyanides - chemistry</subject><subject>Indicators and Reagents</subject><subject>Oxidation-Reduction</subject><subject>Reproducibility of Results</subject><issn>0009-2363</issn><issn>1347-5223</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkc2KFDEUhQtRnHF04wNIQHAhdJv_pFbStvMjjAo6-5BKbk2nqar0JCl0HsJ3Nk23M-AiN4vz5ZxLTtO8JnhJKNcf3K5bCr5sJXvSnBLG1UJQyp42pxjjdkGZZCfNi5y3GFOBFXvenBCpSUsJPW3-rMYdpDhCScGhnzDlmFBfT9kA-gwF0hgmW0KcUOzRKruYugquXPDok83gUVXWsbNDQVfw27p7O8UeUrIF0NfoQx8qcz6AKyl6QBe2q0FV9DUhxfl2gyz6Br_QjzgXeNk86-2Q4dXxPmtuLs5v1leL6--XX9ar64WTkpQFBaZE10qNtSbAFadSKymoa3mLrfWSeExEZ1slO-49CM462uGWCqU98eyseXew3aV4N0MuZgzZwTDYCeKcjdQSc9mKCr79D9zGOU11NUO4xExrynGl3h8ol2LOCXqzS2G06d4QbPYNmdqQEdzUhir85mg5dyP4R_RYSQUuD0BV608NcRrCBI_BLiu3gTEYirE0GAuOVb20wdV-PxTBikipqtPHg9M2F3sLD1E2leAG-LeVOoz96wdlY5OBif0Fgiy5Hg</recordid><startdate>2006</startdate><enddate>2006</enddate><creator>Kumar, Sellappan Senthil</creator><creator>Narayanan, Sangilimuthu Sriman</creator><general>The Pharmaceutical Society of Japan</general><general>Pharmaceutical Society of Japan</general><general>Japan Science and Technology Agency</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>2006</creationdate><title>Amperometric Sensor for the Determination of Ascorbic Acid Based on Cobalt Hexacyanoferrate Modified Electrode Fabricated through a New Route</title><author>Kumar, Sellappan Senthil ; Narayanan, Sangilimuthu Sriman</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c661t-2e375b9680881e4742687652c9490aad61d015ba976b4dde543b2b092578d1d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>aniline</topic><topic>ascorbic acid</topic><topic>Ascorbic Acid - analysis</topic><topic>Ascorbic Acid - chemistry</topic><topic>cobalt hexacyanoferrate</topic><topic>cyclic voltammetry</topic><topic>Electrochemistry - instrumentation</topic><topic>Electrodes</topic><topic>Ferrocyanides - chemistry</topic><topic>Indicators and Reagents</topic><topic>Oxidation-Reduction</topic><topic>Reproducibility of Results</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kumar, Sellappan Senthil</creatorcontrib><creatorcontrib>Narayanan, Sangilimuthu Sriman</creatorcontrib><creatorcontrib>Department of Analytical Chemistry</creatorcontrib><creatorcontrib>School of Chemical Sciences</creatorcontrib><creatorcontrib>University of Madras</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Chemical & Pharmaceutical Bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kumar, Sellappan Senthil</au><au>Narayanan, Sangilimuthu Sriman</au><aucorp>Department of Analytical Chemistry</aucorp><aucorp>School of Chemical Sciences</aucorp><aucorp>University of Madras</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Amperometric Sensor for the Determination of Ascorbic Acid Based on Cobalt Hexacyanoferrate Modified Electrode Fabricated through a New Route</atitle><jtitle>Chemical & Pharmaceutical Bulletin</jtitle><addtitle>Chem. Pharm. Bull.</addtitle><date>2006</date><risdate>2006</risdate><volume>54</volume><issue>7</issue><spage>963</spage><epage>967</epage><pages>963-967</pages><issn>0009-2363</issn><eissn>1347-5223</eissn><abstract>A new approach was attempted to prepare a chemically modified electrode using Cobalt hexacyanoferrate (CoHCF) as the redox mediator and to study its stability and electrocatalytic activity for ascorbic acid (AA) oxidation. The basic principle underlying the electrode modification is the coordination of cobalt ion with the amino nitrogen of aniline adsorbed on the surface of a graphite rod. This surface was subsequently derivatized with ferrocyanide to get CoHCF film on the electrode surface. The CoHCF modified electrode as prepared above was characterized using cyclic voltammetry. The effect of scan rate, supporting electrolyte and pH of the medium on the performance of the modified electrode was investigated. The CoHCF modified electrode exhibited good electrocatalytic activity towards the oxidation of ascorbic acid and gave a linear response from 5.52×10−5 M to 3.23×10−2 M with a correlation coefficient of 0.9929. The detection limit was found to be 3.33×10−5 M. Hydrodynamic voltammetry and chronoamperometry studies for the oxidation of ascorbic acid were also carried out. The electrode was highly stable and exhibited good reproducibility. This modified electrode was also applied for the determination of ascorbic acid in commercial samples.</abstract><cop>Japan</cop><pub>The Pharmaceutical Society of Japan</pub><pmid>16819212</pmid><doi>10.1248/cpb.54.963</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | aniline ascorbic acid Ascorbic Acid - analysis Ascorbic Acid - chemistry cobalt hexacyanoferrate cyclic voltammetry Electrochemistry - instrumentation Electrodes Ferrocyanides - chemistry Indicators and Reagents Oxidation-Reduction Reproducibility of Results |
| title | Amperometric Sensor for the Determination of Ascorbic Acid Based on Cobalt Hexacyanoferrate Modified Electrode Fabricated through a New Route |
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