High ICAM-1 gene expression in pulmonary fibroblasts of COPD patients: a reflection of an enhanced immunological function

Chronic obstructive pulmonary disease (COPD) is characterised by destruction of extracellular matrix (ECM) in parenchymal areas, whereas the bronchial walls can show fibrosis. In addition, an extensive inflammatory process is observed. CD8+ T-cells, located throughout the lung, and epithelial cells...

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Veröffentlicht in:	The European respiratory journal 2006-07, Vol.28 (1), p.113-122
Hauptverfasser:	Zandvoort, A, van der Geld, Y. M, Jonker, M. R, Noordhoek, J. A, Vos, J. T. W. M, Wesseling, J, Kauffman, H. F, Timens, W, Postma, D. S
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Biological and medical sciences CD8-Positive T-Lymphocytes - metabolism Chronic obstructive pulmonary disease, asthma DNA, Complementary - metabolism Extracellular Matrix - metabolism Female Fibroblasts - metabolism Humans Immune System Inflammation Intercellular Adhesion Molecule-1 - biosynthesis Lung - metabolism Male Medical sciences Middle Aged Oligonucleotide Array Sequence Analysis Pneumology Pulmonary Disease, Chronic Obstructive - metabolism
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