Sugar-Sweetened Soft Drink Consumption and Risk of Pancreatic Cancer in Two Prospective Cohorts
Background: A history of diabetes mellitus and a diet high in glycemic load are both potential risk factors for pancreatic cancer. Sugar-sweetened soft drinks are a prevalent source of readily absorbable sugars and have been associated with an increased risk of obesity and diabetes. We investigated...
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| Veröffentlicht in: | Cancer epidemiology, biomarkers & prevention biomarkers & prevention, 2005-09, Vol.14 (9), p.2098-2105 |
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| creator | SCHERNHAMMER, Eva S HU, Frank B GIOVANNUCCI, Ed MICHAUD, Dominique S COLDITZ, Graham A STAMPFER, Meir J FUCHS, Charles S |
| description | Background: A history of diabetes mellitus and a diet high in glycemic load are both potential risk factors for pancreatic
cancer. Sugar-sweetened soft drinks are a prevalent source of readily absorbable sugars and have been associated with an increased
risk of obesity and diabetes. We investigated whether higher consumption of sugar-sweetened soft drinks increases the risk
of pancreatic cancer.
Methods: We examined the relation between consumption of sugar-sweetened soft drinks and the development of pancreatic cancer
in the Nurses' Health Study and the Health Professionals Follow-up Study. Among 88,794 women and 49,364 men without cancer
at baseline, we documented 379 cases of pancreatic cancer during up to 20 years of follow-up. Soft drink consumption was first
assessed at baseline (1980 for the women, 1986 for the men) and updated periodically thereafter.
Results: Compared with participants who largely abstained from sugar-sweetened soft drinks, those who consumed more than three
sugar-sweetened soft drinks weekly experienced overall a multivariate relative risk (RR) of pancreatic cancer of 1.13 [95%
confidence interval (95% CI), 0.81-1.58; P for trend = 0.47]. Women in the highest category of sugar-sweetened soft drink intake did experience a significant increase
in risk (RR, 1.57; 95% CI, 1.02-2.41; P for trend = 0.05), whereas there was no association between sweetened soft drink intake and pancreatic cancer among men.
Among women, the risk associated with higher sugar-sweetened soft drink was limited to those with elevated body mass index
(>25 kg/m 2 ; RR, 1.89; 95% CI, 0.96-3.72) or with low physical activity (RR, 2.02; 95% CI, 1.06-3.85). In contrast, consumption of diet
soft drinks was not associated with an elevated pancreatic cancer risk in either cohort.
Conclusion: Although soft drink consumption did not influence pancreatic cancer risk among men, consumption of sugar-sweetened
soft drinks may be associated with a modest but significant increase in risk among women who have an underlying degree of
insulin resistance. |
| doi_str_mv | 10.1158/1055-9965.EPI-05-0059 |
| format | Article |
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cancer. Sugar-sweetened soft drinks are a prevalent source of readily absorbable sugars and have been associated with an increased
risk of obesity and diabetes. We investigated whether higher consumption of sugar-sweetened soft drinks increases the risk
of pancreatic cancer.
Methods: We examined the relation between consumption of sugar-sweetened soft drinks and the development of pancreatic cancer
in the Nurses' Health Study and the Health Professionals Follow-up Study. Among 88,794 women and 49,364 men without cancer
at baseline, we documented 379 cases of pancreatic cancer during up to 20 years of follow-up. Soft drink consumption was first
assessed at baseline (1980 for the women, 1986 for the men) and updated periodically thereafter.
Results: Compared with participants who largely abstained from sugar-sweetened soft drinks, those who consumed more than three
sugar-sweetened soft drinks weekly experienced overall a multivariate relative risk (RR) of pancreatic cancer of 1.13 [95%
confidence interval (95% CI), 0.81-1.58; P for trend = 0.47]. Women in the highest category of sugar-sweetened soft drink intake did experience a significant increase
in risk (RR, 1.57; 95% CI, 1.02-2.41; P for trend = 0.05), whereas there was no association between sweetened soft drink intake and pancreatic cancer among men.
Among women, the risk associated with higher sugar-sweetened soft drink was limited to those with elevated body mass index
(>25 kg/m 2 ; RR, 1.89; 95% CI, 0.96-3.72) or with low physical activity (RR, 2.02; 95% CI, 1.06-3.85). In contrast, consumption of diet
soft drinks was not associated with an elevated pancreatic cancer risk in either cohort.
Conclusion: Although soft drink consumption did not influence pancreatic cancer risk among men, consumption of sugar-sweetened
soft drinks may be associated with a modest but significant increase in risk among women who have an underlying degree of
insulin resistance.</description><identifier>ISSN: 1055-9965</identifier><identifier>EISSN: 1538-7755</identifier><identifier>DOI: 10.1158/1055-9965.EPI-05-0059</identifier><identifier>PMID: 16172216</identifier><language>eng</language><publisher>Philadelphia, PA: American Association for Cancer Research</publisher><subject>Adult ; Beverages ; Biological and medical sciences ; Dietary Sucrose - adverse effects ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Humans ; Life Style ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Male ; Medical sciences ; Middle Aged ; pancreatic cancer ; Pancreatic Neoplasms - epidemiology ; Pancreatic Neoplasms - etiology ; Physical Fitness ; prospective cohort study ; Prospective Studies ; Risk Factors ; Sex Factors ; soft drinks ; Tumors</subject><ispartof>Cancer epidemiology, biomarkers & prevention, 2005-09, Vol.14 (9), p.2098-2105</ispartof><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c566t-c0ce592945b8f6762c63e1613850c3cbadebcec2b4660f824ef222e8afd0a0503</citedby><cites>FETCH-LOGICAL-c566t-c0ce592945b8f6762c63e1613850c3cbadebcec2b4660f824ef222e8afd0a0503</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,3356,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17130443$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16172216$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SCHERNHAMMER, Eva S</creatorcontrib><creatorcontrib>HU, Frank B</creatorcontrib><creatorcontrib>GIOVANNUCCI, Ed</creatorcontrib><creatorcontrib>MICHAUD, Dominique S</creatorcontrib><creatorcontrib>COLDITZ, Graham A</creatorcontrib><creatorcontrib>STAMPFER, Meir J</creatorcontrib><creatorcontrib>FUCHS, Charles S</creatorcontrib><title>Sugar-Sweetened Soft Drink Consumption and Risk of Pancreatic Cancer in Two Prospective Cohorts</title><title>Cancer epidemiology, biomarkers & prevention</title><addtitle>Cancer Epidemiol Biomarkers Prev</addtitle><description>Background: A history of diabetes mellitus and a diet high in glycemic load are both potential risk factors for pancreatic
cancer. Sugar-sweetened soft drinks are a prevalent source of readily absorbable sugars and have been associated with an increased
risk of obesity and diabetes. We investigated whether higher consumption of sugar-sweetened soft drinks increases the risk
of pancreatic cancer.
Methods: We examined the relation between consumption of sugar-sweetened soft drinks and the development of pancreatic cancer
in the Nurses' Health Study and the Health Professionals Follow-up Study. Among 88,794 women and 49,364 men without cancer
at baseline, we documented 379 cases of pancreatic cancer during up to 20 years of follow-up. Soft drink consumption was first
assessed at baseline (1980 for the women, 1986 for the men) and updated periodically thereafter.
Results: Compared with participants who largely abstained from sugar-sweetened soft drinks, those who consumed more than three
sugar-sweetened soft drinks weekly experienced overall a multivariate relative risk (RR) of pancreatic cancer of 1.13 [95%
confidence interval (95% CI), 0.81-1.58; P for trend = 0.47]. Women in the highest category of sugar-sweetened soft drink intake did experience a significant increase
in risk (RR, 1.57; 95% CI, 1.02-2.41; P for trend = 0.05), whereas there was no association between sweetened soft drink intake and pancreatic cancer among men.
Among women, the risk associated with higher sugar-sweetened soft drink was limited to those with elevated body mass index
(>25 kg/m 2 ; RR, 1.89; 95% CI, 0.96-3.72) or with low physical activity (RR, 2.02; 95% CI, 1.06-3.85). In contrast, consumption of diet
soft drinks was not associated with an elevated pancreatic cancer risk in either cohort.
Conclusion: Although soft drink consumption did not influence pancreatic cancer risk among men, consumption of sugar-sweetened
soft drinks may be associated with a modest but significant increase in risk among women who have an underlying degree of
insulin resistance.</description><subject>Adult</subject><subject>Beverages</subject><subject>Biological and medical sciences</subject><subject>Dietary Sucrose - adverse effects</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>Life Style</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>pancreatic cancer</subject><subject>Pancreatic Neoplasms - epidemiology</subject><subject>Pancreatic Neoplasms - etiology</subject><subject>Physical Fitness</subject><subject>prospective cohort study</subject><subject>Prospective Studies</subject><subject>Risk Factors</subject><subject>Sex Factors</subject><subject>soft drinks</subject><subject>Tumors</subject><issn>1055-9965</issn><issn>1538-7755</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFvFCEYhonR2Fr9CRouGi9TP2Bg4Gi2VZs0cePWM2GYjy52d1hhxo3_XtZd06MnvsPzAt_zEvKawSVjUn9gIGVjjJKX18ubBmQDIM0Tcs6k0E3XSfm0zv-YM_KilB8A0Bkpn5MzpljHOVPnxK7me5eb1R5xwhEHukpholc5jg90kcYyb3dTTCN140C_xfJAU6BLN_qMboqeLuqImcaR3u0TXeZUduin-AtreJ3yVF6SZ8FtCr46nRfk-6fru8WX5vbr55vFx9vGS6WmxoNHabhpZa-D6hT3SmD9pdASvPC9G7D36HnfKgVB8xYD5xy1CwM4kCAuyLvjvbucfs5YJruNxeNm40ZMc7FKK2iFZv8FWdeyDrSpoDyCvm5VMga7y3Hr8m_LwB4qsAe99qDX1gosSHuooObenB6Y-y0Oj6mT8wq8PQGueLcJuTqM5ZHrmIC2FZV7f-TW8X69jxmt_2s7Y0GX_dqy1hrLwWjxB_NWnSM</recordid><startdate>20050901</startdate><enddate>20050901</enddate><creator>SCHERNHAMMER, Eva S</creator><creator>HU, Frank B</creator><creator>GIOVANNUCCI, Ed</creator><creator>MICHAUD, Dominique S</creator><creator>COLDITZ, Graham A</creator><creator>STAMPFER, Meir J</creator><creator>FUCHS, Charles S</creator><general>American Association for Cancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>20050901</creationdate><title>Sugar-Sweetened Soft Drink Consumption and Risk of Pancreatic Cancer in Two Prospective Cohorts</title><author>SCHERNHAMMER, Eva S ; HU, Frank B ; GIOVANNUCCI, Ed ; MICHAUD, Dominique S ; COLDITZ, Graham A ; STAMPFER, Meir J ; FUCHS, Charles S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c566t-c0ce592945b8f6762c63e1613850c3cbadebcec2b4660f824ef222e8afd0a0503</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>Beverages</topic><topic>Biological and medical sciences</topic><topic>Dietary Sucrose - adverse effects</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Humans</topic><topic>Life Style</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>pancreatic cancer</topic><topic>Pancreatic Neoplasms - epidemiology</topic><topic>Pancreatic Neoplasms - etiology</topic><topic>Physical Fitness</topic><topic>prospective cohort study</topic><topic>Prospective Studies</topic><topic>Risk Factors</topic><topic>Sex Factors</topic><topic>soft drinks</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SCHERNHAMMER, Eva S</creatorcontrib><creatorcontrib>HU, Frank B</creatorcontrib><creatorcontrib>GIOVANNUCCI, Ed</creatorcontrib><creatorcontrib>MICHAUD, Dominique S</creatorcontrib><creatorcontrib>COLDITZ, Graham A</creatorcontrib><creatorcontrib>STAMPFER, Meir J</creatorcontrib><creatorcontrib>FUCHS, Charles S</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer epidemiology, biomarkers & prevention</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SCHERNHAMMER, Eva S</au><au>HU, Frank B</au><au>GIOVANNUCCI, Ed</au><au>MICHAUD, Dominique S</au><au>COLDITZ, Graham A</au><au>STAMPFER, Meir J</au><au>FUCHS, Charles S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sugar-Sweetened Soft Drink Consumption and Risk of Pancreatic Cancer in Two Prospective Cohorts</atitle><jtitle>Cancer epidemiology, biomarkers & prevention</jtitle><addtitle>Cancer Epidemiol Biomarkers Prev</addtitle><date>2005-09-01</date><risdate>2005</risdate><volume>14</volume><issue>9</issue><spage>2098</spage><epage>2105</epage><pages>2098-2105</pages><issn>1055-9965</issn><eissn>1538-7755</eissn><abstract>Background: A history of diabetes mellitus and a diet high in glycemic load are both potential risk factors for pancreatic
cancer. Sugar-sweetened soft drinks are a prevalent source of readily absorbable sugars and have been associated with an increased
risk of obesity and diabetes. We investigated whether higher consumption of sugar-sweetened soft drinks increases the risk
of pancreatic cancer.
Methods: We examined the relation between consumption of sugar-sweetened soft drinks and the development of pancreatic cancer
in the Nurses' Health Study and the Health Professionals Follow-up Study. Among 88,794 women and 49,364 men without cancer
at baseline, we documented 379 cases of pancreatic cancer during up to 20 years of follow-up. Soft drink consumption was first
assessed at baseline (1980 for the women, 1986 for the men) and updated periodically thereafter.
Results: Compared with participants who largely abstained from sugar-sweetened soft drinks, those who consumed more than three
sugar-sweetened soft drinks weekly experienced overall a multivariate relative risk (RR) of pancreatic cancer of 1.13 [95%
confidence interval (95% CI), 0.81-1.58; P for trend = 0.47]. Women in the highest category of sugar-sweetened soft drink intake did experience a significant increase
in risk (RR, 1.57; 95% CI, 1.02-2.41; P for trend = 0.05), whereas there was no association between sweetened soft drink intake and pancreatic cancer among men.
Among women, the risk associated with higher sugar-sweetened soft drink was limited to those with elevated body mass index
(>25 kg/m 2 ; RR, 1.89; 95% CI, 0.96-3.72) or with low physical activity (RR, 2.02; 95% CI, 1.06-3.85). In contrast, consumption of diet
soft drinks was not associated with an elevated pancreatic cancer risk in either cohort.
Conclusion: Although soft drink consumption did not influence pancreatic cancer risk among men, consumption of sugar-sweetened
soft drinks may be associated with a modest but significant increase in risk among women who have an underlying degree of
insulin resistance.</abstract><cop>Philadelphia, PA</cop><pub>American Association for Cancer Research</pub><pmid>16172216</pmid><doi>10.1158/1055-9965.EPI-05-0059</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Cancer epidemiology, biomarkers & prevention, 2005-09, Vol.14 (9), p.2098-2105 |
| issn | 1055-9965 1538-7755 |
| language | eng |
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| source | MEDLINE; American Association for Cancer Research; EZB-FREE-00999 freely available EZB journals |
| subjects | Adult Beverages Biological and medical sciences Dietary Sucrose - adverse effects Female Gastroenterology. Liver. Pancreas. Abdomen Humans Life Style Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences Middle Aged pancreatic cancer Pancreatic Neoplasms - epidemiology Pancreatic Neoplasms - etiology Physical Fitness prospective cohort study Prospective Studies Risk Factors Sex Factors soft drinks Tumors |
| title | Sugar-Sweetened Soft Drink Consumption and Risk of Pancreatic Cancer in Two Prospective Cohorts |
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