Mutation screen and association study of EZH2 as a susceptibility gene for aggressive prostate cancer
BACKGROUND Several linkage studies have provided evidence for a prostate cancer aggressiveness gene on chromosome 7q. This report details the results of the first mutation screen and association study of EZH2 (located at 7q35) as a potential candidate gene for the development of aggressive prostate...
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| Veröffentlicht in: | The Prostate 2005-11, Vol.65 (3), p.252-259 |
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| creator | Bachmann, Natascha Hoegel, Josef Haeusler, Juergen Kuefer, Rainer Herkommer, Kathleen Paiss, Thomas Vogel, Walther Maier, Christiane |
| description | BACKGROUND
Several linkage studies have provided evidence for a prostate cancer aggressiveness gene on chromosome 7q. This report details the results of the first mutation screen and association study of EZH2 (located at 7q35) as a potential candidate gene for the development of aggressive prostate cancer.
METHODS
In 10 families with linkage of chromosome 7q31‐33 to aggressive prostate cancer, we sequenced the promoter region and all 20 exons of EZH2. We genotyped 11 variants in 287 prostate cancer probands and 96 controls. Association between the disease and the variants/haplotypes was evaluated taking into account clinical data and disease recurrence.
RESULTS
The individual variation sites did not show significant differences in the allele frequencies between cases and controls. In contrast, one haplotype had a higher frequency in controls, and another haplotype was significantly more frequent in cases with low grade tumors (GI/II) and progression free survival (NED).
CONCLUSION
We have possibly identified haplotypes which mark alleles that have a beneficial effect on the development of prostate cancer. Moreover, our results suggest that genetic variations of the EZH2 gene are not responsible for the linkage of 7q to aggressive prostate cancer. Prostate. © 2005 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/pros.20296 |
| format | Article |
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Several linkage studies have provided evidence for a prostate cancer aggressiveness gene on chromosome 7q. This report details the results of the first mutation screen and association study of EZH2 (located at 7q35) as a potential candidate gene for the development of aggressive prostate cancer.
METHODS
In 10 families with linkage of chromosome 7q31‐33 to aggressive prostate cancer, we sequenced the promoter region and all 20 exons of EZH2. We genotyped 11 variants in 287 prostate cancer probands and 96 controls. Association between the disease and the variants/haplotypes was evaluated taking into account clinical data and disease recurrence.
RESULTS
The individual variation sites did not show significant differences in the allele frequencies between cases and controls. In contrast, one haplotype had a higher frequency in controls, and another haplotype was significantly more frequent in cases with low grade tumors (GI/II) and progression free survival (NED).
CONCLUSION
We have possibly identified haplotypes which mark alleles that have a beneficial effect on the development of prostate cancer. Moreover, our results suggest that genetic variations of the EZH2 gene are not responsible for the linkage of 7q to aggressive prostate cancer. Prostate. © 2005 Wiley‐Liss, Inc.</description><identifier>ISSN: 0270-4137</identifier><identifier>EISSN: 1097-0045</identifier><identifier>DOI: 10.1002/pros.20296</identifier><identifier>PMID: 16015586</identifier><identifier>CODEN: PRSTDS</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adult ; Aged ; Aged, 80 and over ; aggressiveness ; Alleles ; Biological and medical sciences ; DNA, Neoplasm - genetics ; DNA-Binding Proteins ; Enhancer of Zeste Homolog 2 Protein ; EZH2 ; Genetic Predisposition to Disease ; Genotype ; Gynecology. Andrology. Obstetrics ; Haplotypes ; Humans ; Linkage Disequilibrium - genetics ; Male ; Male genital diseases ; Medical sciences ; Middle Aged ; Nephrology. Urinary tract diseases ; Polycomb Repressive Complex 2 ; Polymerase Chain Reaction ; Polymorphism, Single Nucleotide ; prostate cancer ; Prostatic Neoplasms - genetics ; Prostatic Neoplasms - pathology ; Proteins - genetics ; Sequence Analysis, DNA ; Transcription Factors ; Tumors ; Tumors of the urinary system ; Urinary tract. Prostate gland</subject><ispartof>The Prostate, 2005-11, Vol.65 (3), p.252-259</ispartof><rights>Copyright © 2005 Wiley‐Liss, Inc.</rights><rights>2005 INIST-CNRS</rights><rights>Copyright 2005 Wiley-Liss, Inc</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3956-edf9adad99059f5eb382d763086760c7734a956553349dd835606d2e215290633</citedby><cites>FETCH-LOGICAL-c3956-edf9adad99059f5eb382d763086760c7734a956553349dd835606d2e215290633</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fpros.20296$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fpros.20296$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17247502$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16015586$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bachmann, Natascha</creatorcontrib><creatorcontrib>Hoegel, Josef</creatorcontrib><creatorcontrib>Haeusler, Juergen</creatorcontrib><creatorcontrib>Kuefer, Rainer</creatorcontrib><creatorcontrib>Herkommer, Kathleen</creatorcontrib><creatorcontrib>Paiss, Thomas</creatorcontrib><creatorcontrib>Vogel, Walther</creatorcontrib><creatorcontrib>Maier, Christiane</creatorcontrib><title>Mutation screen and association study of EZH2 as a susceptibility gene for aggressive prostate cancer</title><title>The Prostate</title><addtitle>Prostate</addtitle><description>BACKGROUND
Several linkage studies have provided evidence for a prostate cancer aggressiveness gene on chromosome 7q. This report details the results of the first mutation screen and association study of EZH2 (located at 7q35) as a potential candidate gene for the development of aggressive prostate cancer.
METHODS
In 10 families with linkage of chromosome 7q31‐33 to aggressive prostate cancer, we sequenced the promoter region and all 20 exons of EZH2. We genotyped 11 variants in 287 prostate cancer probands and 96 controls. Association between the disease and the variants/haplotypes was evaluated taking into account clinical data and disease recurrence.
RESULTS
The individual variation sites did not show significant differences in the allele frequencies between cases and controls. In contrast, one haplotype had a higher frequency in controls, and another haplotype was significantly more frequent in cases with low grade tumors (GI/II) and progression free survival (NED).
CONCLUSION
We have possibly identified haplotypes which mark alleles that have a beneficial effect on the development of prostate cancer. Moreover, our results suggest that genetic variations of the EZH2 gene are not responsible for the linkage of 7q to aggressive prostate cancer. Prostate. © 2005 Wiley‐Liss, Inc.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>aggressiveness</subject><subject>Alleles</subject><subject>Biological and medical sciences</subject><subject>DNA, Neoplasm - genetics</subject><subject>DNA-Binding Proteins</subject><subject>Enhancer of Zeste Homolog 2 Protein</subject><subject>EZH2</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Haplotypes</subject><subject>Humans</subject><subject>Linkage Disequilibrium - genetics</subject><subject>Male</subject><subject>Male genital diseases</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Polycomb Repressive Complex 2</subject><subject>Polymerase Chain Reaction</subject><subject>Polymorphism, Single Nucleotide</subject><subject>prostate cancer</subject><subject>Prostatic Neoplasms - genetics</subject><subject>Prostatic Neoplasms - pathology</subject><subject>Proteins - genetics</subject><subject>Sequence Analysis, DNA</subject><subject>Transcription Factors</subject><subject>Tumors</subject><subject>Tumors of the urinary system</subject><subject>Urinary tract. Prostate gland</subject><issn>0270-4137</issn><issn>1097-0045</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1u1DAUhS0EokNhwwMgb2CBlHJtx3a8RFU7BbUU8VMkNpbHvhkZMsnUToB5ezxMoDtWtuzvnnPuIeQpgxMGwF9t05BPOHCj7pEFA6MrgFreJwvgGqqaCX1EHuX8DaDgwB-SI6aASdmoBcGraXRjHHqafULsqesDdTkPPs7P4xR2dGjp2dcLXn6oo3nKHrdjXMUujju6xh5pOyTq1uuEOccfSPeRii5S73qP6TF50Lou45P5PCafz88-nV5Ul9fLN6evLysvjFQVhta44IIxIE0rcSUaHrQS0CitwGstalc4KYWoTQiNkApU4MiZ5AaUEMfkxUG3-N9OmEe7iSVr17kehylb1SioOezBlwfQl6A5YWu3KW5c2lkGdl-q3W9g_5Ra4Gez6rTaYLhD5xYL8HwGXPaua1NZOuY7TvNaS-CFYwfuZ-xw9x9L-_7D9ce_5tVhJuYRf_2bcem7VVpoab-8W9rl1Q17e35TLuI3u12dxw</recordid><startdate>20051101</startdate><enddate>20051101</enddate><creator>Bachmann, Natascha</creator><creator>Hoegel, Josef</creator><creator>Haeusler, Juergen</creator><creator>Kuefer, Rainer</creator><creator>Herkommer, Kathleen</creator><creator>Paiss, Thomas</creator><creator>Vogel, Walther</creator><creator>Maier, Christiane</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20051101</creationdate><title>Mutation screen and association study of EZH2 as a susceptibility gene for aggressive prostate cancer</title><author>Bachmann, Natascha ; Hoegel, Josef ; Haeusler, Juergen ; Kuefer, Rainer ; Herkommer, Kathleen ; Paiss, Thomas ; Vogel, Walther ; Maier, Christiane</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3956-edf9adad99059f5eb382d763086760c7734a956553349dd835606d2e215290633</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>aggressiveness</topic><topic>Alleles</topic><topic>Biological and medical sciences</topic><topic>DNA, Neoplasm - genetics</topic><topic>DNA-Binding Proteins</topic><topic>Enhancer of Zeste Homolog 2 Protein</topic><topic>EZH2</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotype</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Haplotypes</topic><topic>Humans</topic><topic>Linkage Disequilibrium - genetics</topic><topic>Male</topic><topic>Male genital diseases</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Polycomb Repressive Complex 2</topic><topic>Polymerase Chain Reaction</topic><topic>Polymorphism, Single Nucleotide</topic><topic>prostate cancer</topic><topic>Prostatic Neoplasms - genetics</topic><topic>Prostatic Neoplasms - pathology</topic><topic>Proteins - genetics</topic><topic>Sequence Analysis, DNA</topic><topic>Transcription Factors</topic><topic>Tumors</topic><topic>Tumors of the urinary system</topic><topic>Urinary tract. Prostate gland</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bachmann, Natascha</creatorcontrib><creatorcontrib>Hoegel, Josef</creatorcontrib><creatorcontrib>Haeusler, Juergen</creatorcontrib><creatorcontrib>Kuefer, Rainer</creatorcontrib><creatorcontrib>Herkommer, Kathleen</creatorcontrib><creatorcontrib>Paiss, Thomas</creatorcontrib><creatorcontrib>Vogel, Walther</creatorcontrib><creatorcontrib>Maier, Christiane</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Prostate</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bachmann, Natascha</au><au>Hoegel, Josef</au><au>Haeusler, Juergen</au><au>Kuefer, Rainer</au><au>Herkommer, Kathleen</au><au>Paiss, Thomas</au><au>Vogel, Walther</au><au>Maier, Christiane</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mutation screen and association study of EZH2 as a susceptibility gene for aggressive prostate cancer</atitle><jtitle>The Prostate</jtitle><addtitle>Prostate</addtitle><date>2005-11-01</date><risdate>2005</risdate><volume>65</volume><issue>3</issue><spage>252</spage><epage>259</epage><pages>252-259</pages><issn>0270-4137</issn><eissn>1097-0045</eissn><coden>PRSTDS</coden><abstract>BACKGROUND
Several linkage studies have provided evidence for a prostate cancer aggressiveness gene on chromosome 7q. This report details the results of the first mutation screen and association study of EZH2 (located at 7q35) as a potential candidate gene for the development of aggressive prostate cancer.
METHODS
In 10 families with linkage of chromosome 7q31‐33 to aggressive prostate cancer, we sequenced the promoter region and all 20 exons of EZH2. We genotyped 11 variants in 287 prostate cancer probands and 96 controls. Association between the disease and the variants/haplotypes was evaluated taking into account clinical data and disease recurrence.
RESULTS
The individual variation sites did not show significant differences in the allele frequencies between cases and controls. In contrast, one haplotype had a higher frequency in controls, and another haplotype was significantly more frequent in cases with low grade tumors (GI/II) and progression free survival (NED).
CONCLUSION
We have possibly identified haplotypes which mark alleles that have a beneficial effect on the development of prostate cancer. Moreover, our results suggest that genetic variations of the EZH2 gene are not responsible for the linkage of 7q to aggressive prostate cancer. Prostate. © 2005 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>16015586</pmid><doi>10.1002/pros.20296</doi><tpages>8</tpages></addata></record> |
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| subjects | Adult Aged Aged, 80 and over aggressiveness Alleles Biological and medical sciences DNA, Neoplasm - genetics DNA-Binding Proteins Enhancer of Zeste Homolog 2 Protein EZH2 Genetic Predisposition to Disease Genotype Gynecology. Andrology. Obstetrics Haplotypes Humans Linkage Disequilibrium - genetics Male Male genital diseases Medical sciences Middle Aged Nephrology. Urinary tract diseases Polycomb Repressive Complex 2 Polymerase Chain Reaction Polymorphism, Single Nucleotide prostate cancer Prostatic Neoplasms - genetics Prostatic Neoplasms - pathology Proteins - genetics Sequence Analysis, DNA Transcription Factors Tumors Tumors of the urinary system Urinary tract. Prostate gland |
| title | Mutation screen and association study of EZH2 as a susceptibility gene for aggressive prostate cancer |
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