Thermodynamics of non-stoichiometric pharmaceutical hydrates
Different physical and mathematical models of non-stoichiometric hydrates derived form previous work in inorganic hydrates are reviewed. A theoretical link between the order of water molecules in the hydrate and the shape of the isotherm is outlined. The comparison of the models with sorption isothe...
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| Veröffentlicht in: | International journal of pharmaceutics 2005-10, Vol.303 (1), p.37-53 |
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| container_title | International journal of pharmaceutics |
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| creator | Authelin, Jean-René |
| description | Different physical and mathematical models of non-stoichiometric hydrates derived form previous work in inorganic hydrates are reviewed. A theoretical link between the order of water molecules in the hydrate and the shape of the isotherm is outlined. The comparison of the models with sorption isotherms and structural data of well-known cases from the literature and one in-house case shows that the model can fit many experimental situations and is in good agreement with qualitative assessments of the order in the hydrates. |
| doi_str_mv | 10.1016/j.ijpharm.2005.07.007 |
| format | Article |
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| ispartof | International journal of pharmaceutics, 2005-10, Vol.303 (1), p.37-53 |
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| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Adsorption Biological and medical sciences Celiprolol - chemistry Enalapril - analogs & derivatives Enalapril - chemistry Erythromycin - chemistry General pharmacology Medical sciences Models, Theoretical Non-stoichiometric hydrates Pharmaceutical Preparations - chemistry Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Structure–sorption isotherm relationship Thermodynamics Water - chemistry |
| title | Thermodynamics of non-stoichiometric pharmaceutical hydrates |
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