Paucity of V-D-D-J Rearrangements and VH Replacement Events in Lupus Prone and Nonautoimmune TdT-/- and TdT+/+ Mice

CDR3 regions containing two D segments, or containing the footprints of V(H) replacement events, have been reported in both mice and humans. However, the 12-23 bp rule for V(D)J recombination predicts that D-D rearrangements, which would occur between 2 recombination signal sequences (RSSs) with 12-...

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Veröffentlicht in:	The Journal of immunology (1950) 2006-07, Vol.177 (2), p.1120-1128
Hauptverfasser:	Watson, Lisa C, Moffatt-Blue, Chantelle S, McDonald, R. Zachary, Kompfner, Elizabeth, Ait-Azzouzene, Djemel, Nemazee, David, Theofilopoulos, Argyrios N, Kono, Dwight H, Feeney, Ann J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibody Diversity - genetics Complementarity Determining Regions - genetics DNA Damage DNA Footprinting DNA Nucleotidylexotransferase - biosynthesis DNA Nucleotidylexotransferase - deficiency DNA Nucleotidylexotransferase - genetics Gene Rearrangement, B-Lymphocyte, Heavy Chain Genetic Predisposition to Disease Germ-Line Mutation Hematopoietic Stem Cells - enzymology Hematopoietic Stem Cells - immunology Hematopoietic Stem Cells - pathology Immunoglobulin Heavy Chains - genetics Immunoglobulin Joining Region - genetics Immunoglobulin Variable Region - genetics Lupus Nephritis - enzymology Lupus Nephritis - genetics Lupus Nephritis - immunology Lupus Nephritis - pathology Mice Mice, Inbred C57BL Mice, Inbred MRL lpr Mice, Inbred NZB Mice, Knockout Mice, Transgenic Polymerase Chain Reaction RNA Editing - genetics RNA Editing - immunology
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