LPS regulates proinflammatory gene expression in macrophages by altering histone deacetylase expression

Bacterial LPS triggers dramatic changes in gene expression in macrophages. We show here that LPS regulated several members of the histone deacetylase (HDAC) family at the mRNA level in murine bone marrow-derived macrophages (BMM). LPS transiently repressed, then induced a number of HDACs (Hdac-4, 5,...

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Veröffentlicht in:	The FASEB journal 2006-07, Vol.20 (9), p.1315-1327
Hauptverfasser:	Aung, Hnin Thanda, Schroder, Kate, Himes, Stewart R, Brion, Kristian, van Zuylen, Wendy, Trieu, Angela, Suzuki, Harukazu, Hayashizaki, Yoshihide, Hume, David A, Sweet, Matthew J, Ravasi, Timothy
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bone Marrow Cells - cytology Cell Line Cloning, Molecular Cyclooxygenase 2 - genetics Enzyme Inhibitors - pharmacology epigenetic Gene Expression Regulation, Enzymologic - drug effects histone code Histone Deacetylase Inhibitors Histone Deacetylases - genetics Hydroxamic Acids - pharmacology inflammation Inflammation - genetics innate immunity Lipopolysaccharides - pharmacology Macrophages - physiology Mice Mice, Inbred C57BL Polymerase Chain Reaction Promoter Regions, Genetic transcriptional regulatory networks
Online-Zugang:	Volltext
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