Pharmacologic Basis for the Enhanced Efficacy of Dutasteride against Prostatic Cancers

Purpose: Prostatic dihydrotestosterone (DHT) concentration is regulated by precursors from systemic circulation and prostatic enzymes of androgen metabolism, particularly 5α-reductases (i.e., SRD5A1 and SRD5A2). Therefore, the levels of expression SRD5A1 and SRD5A2 and the antiprostatic cancer growt...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Clinical cancer research 2006-07, Vol.12 (13), p.4072-4079
Hauptverfasser:	Xu, Yi, Dalrymple, Susan L, Becker, Robyn E, Denmeade, Samuel R, Isaacs, John T
Format:	Artikel
Sprache:	eng
Schlagworte:	3-Oxo-5-alpha-Steroid 4-Dehydrogenase - genetics 5-alpha Reductase Inhibitors 5α-reductase inhibitors Administration, Oral Animals Azasteroids - chemistry Azasteroids - pharmacology Azasteroids - therapeutic use Cell Line, Tumor Cell Proliferation - drug effects Chromatography, Liquid - methods Dihydrotestosterone - administration & dosage Dihydrotestosterone - chemistry Dihydrotestosterone - pharmacology Disease Models, Animal Dutasteride Enzyme Activation - drug effects Enzyme Inhibitors - administration & dosage Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Finasteride - administration & dosage Finasteride - chemistry Finasteride - pharmacology Gene Expression Profiling Humans Male Mass Spectrometry - methods Mice Mice, Nude Molecular Conformation prostate cancer Prostatic Neoplasms - drug therapy Prostatic Neoplasms - metabolism Protein Isoforms - antagonists & inhibitors Protein Isoforms - genetics Rats Reverse Transcriptase Polymerase Chain Reaction - methods RNA, Messenger - antagonists & inhibitors RNA, Messenger - genetics Structure-Activity Relationship Xenograft Model Antitumor Assays
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!