Formation and Characterization of Stable Human Serum Albumin−Tris-malonic Acid [C60]Fullerene Complex
The preparation and characterization of the stable human serum albumin (HSA)-C3 isomer of tris-malonic acid [C60]fullerene complex is reported. Other than the anti-fullerene antibody, a stable protein−fullerene complex with a native protein has never been observed. This study may provide valuable an...
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| Veröffentlicht in: | Bioconjugate chemistry 2005-09, Vol.16 (5), p.1058-1062 |
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| container_end_page | 1062 |
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| container_issue | 5 |
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| container_title | Bioconjugate chemistry |
| container_volume | 16 |
| creator | Belgorodsky, Bogdan Fadeev, Ludmila Ittah, Varda Benyamini, Hadar Zelner, Stanislav Huppert, Dan Kotlyar, Alexander B Gozin, Michael |
| description | The preparation and characterization of the stable human serum albumin (HSA)-C3 isomer of tris-malonic acid [C60]fullerene complex is reported. Other than the anti-fullerene antibody, a stable protein−fullerene complex with a native protein has never been observed. This study may provide valuable answers to the growing concern regarding the effects of carbonaceous nanomaterials on human health on one hand and, on the other, may lead to the development of novel antioxidant therapeutic agents, radiopharmaceuticals, and components for bioelectronic devices. |
| doi_str_mv | 10.1021/bc050103c |
| format | Article |
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Other than the anti-fullerene antibody, a stable protein−fullerene complex with a native protein has never been observed. This study may provide valuable answers to the growing concern regarding the effects of carbonaceous nanomaterials on human health on one hand and, on the other, may lead to the development of novel antioxidant therapeutic agents, radiopharmaceuticals, and components for bioelectronic devices.</description><identifier>ISSN: 1043-1802</identifier><identifier>EISSN: 1520-4812</identifier><identifier>DOI: 10.1021/bc050103c</identifier><identifier>PMID: 16173780</identifier><language>eng</language><publisher>United States: American Chemical Society</publisher><subject>Acids ; Biochemistry ; Chromatography, Gel ; Cytochromes c - chemistry ; Cytochromes c - metabolism ; Fullerenes - chemistry ; Humans ; Immunoglobulins ; Malonates - chemistry ; Models, Molecular ; Protein Structure, Tertiary ; Proteins ; Serum Albumin - chemistry ; Spectrometry, Fluorescence ; Spectrometry, Mass, Electrospray Ionization ; Superoxide Dismutase - chemistry ; Superoxide Dismutase - metabolism ; Tromethamine - chemistry ; Xanthine Oxidase - chemistry ; Xanthine Oxidase - metabolism</subject><ispartof>Bioconjugate chemistry, 2005-09, Vol.16 (5), p.1058-1062</ispartof><rights>Copyright © 2005 American Chemical Society</rights><rights>Copyright American Chemical Society Sep/Oct 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a473t-545cbef5bf9ae18c61424c93ee5e8c65ff81907e6dde50263ad688740b1365173</citedby><cites>FETCH-LOGICAL-a473t-545cbef5bf9ae18c61424c93ee5e8c65ff81907e6dde50263ad688740b1365173</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/bc050103c$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/bc050103c$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,778,782,2754,27063,27911,27912,56725,56775</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16173780$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Belgorodsky, Bogdan</creatorcontrib><creatorcontrib>Fadeev, Ludmila</creatorcontrib><creatorcontrib>Ittah, Varda</creatorcontrib><creatorcontrib>Benyamini, Hadar</creatorcontrib><creatorcontrib>Zelner, Stanislav</creatorcontrib><creatorcontrib>Huppert, Dan</creatorcontrib><creatorcontrib>Kotlyar, Alexander B</creatorcontrib><creatorcontrib>Gozin, Michael</creatorcontrib><title>Formation and Characterization of Stable Human Serum Albumin−Tris-malonic Acid [C60]Fullerene Complex</title><title>Bioconjugate chemistry</title><addtitle>Bioconjugate Chem</addtitle><description>The preparation and characterization of the stable human serum albumin (HSA)-C3 isomer of tris-malonic acid [C60]fullerene complex is reported. Other than the anti-fullerene antibody, a stable protein−fullerene complex with a native protein has never been observed. This study may provide valuable answers to the growing concern regarding the effects of carbonaceous nanomaterials on human health on one hand and, on the other, may lead to the development of novel antioxidant therapeutic agents, radiopharmaceuticals, and components for bioelectronic devices.</description><subject>Acids</subject><subject>Biochemistry</subject><subject>Chromatography, Gel</subject><subject>Cytochromes c - chemistry</subject><subject>Cytochromes c - metabolism</subject><subject>Fullerenes - chemistry</subject><subject>Humans</subject><subject>Immunoglobulins</subject><subject>Malonates - chemistry</subject><subject>Models, Molecular</subject><subject>Protein Structure, Tertiary</subject><subject>Proteins</subject><subject>Serum Albumin - chemistry</subject><subject>Spectrometry, Fluorescence</subject><subject>Spectrometry, Mass, Electrospray Ionization</subject><subject>Superoxide Dismutase - chemistry</subject><subject>Superoxide Dismutase - metabolism</subject><subject>Tromethamine - chemistry</subject><subject>Xanthine Oxidase - chemistry</subject><subject>Xanthine Oxidase - metabolism</subject><issn>1043-1802</issn><issn>1520-4812</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNplkN9qFDEUh4Mo9o9e-AISBIVejCaZSSZ7uQzuViho2bU3IiGTOaOpyWRNZqD1CbzuI_ZJmjJLC3qVk5yPc375EHpFyXtKGP3QGsIJJaV5gg4pZ6SoJGVPc02qsqCSsAN0lNIlIWRBJXuODqigdVlLcoh-rEL0erRhwHrocPNTR21GiPbP_Bh6vBl16wCfTl4PeANx8njp2snb4fbvzTbaVHjtwmANXhrb4W-NIN9Xk3MQYQDcBL9zcPUCPeu1S_Byfx6jr6uP2-a0OPu8_tQszwpd1eVY8IqbFnre9gsNVBpBK1aZRQnAId9430u6IDWIrgNOmCh1J6SsK9LSUvD8qWP0bp67i-H3BGlU3iYDzukBwpSUkCJb4DKDb_4BL8MUh5xNMSpY1kpZhk5myMSQUoRe7aL1Ol4rStS9evWgPrOv9wOn1kP3SO5dZ6CYAZtGuHro6_hLiUxwtf2yUWvJL84vztfqPuHbmdcmPYb7f_EdxO-ZUQ</recordid><startdate>20050901</startdate><enddate>20050901</enddate><creator>Belgorodsky, Bogdan</creator><creator>Fadeev, Ludmila</creator><creator>Ittah, Varda</creator><creator>Benyamini, Hadar</creator><creator>Zelner, Stanislav</creator><creator>Huppert, Dan</creator><creator>Kotlyar, Alexander B</creator><creator>Gozin, Michael</creator><general>American Chemical Society</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20050901</creationdate><title>Formation and Characterization of Stable Human Serum Albumin−Tris-malonic Acid [C60]Fullerene Complex</title><author>Belgorodsky, Bogdan ; 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| fulltext | fulltext |
| identifier | ISSN: 1043-1802 |
| ispartof | Bioconjugate chemistry, 2005-09, Vol.16 (5), p.1058-1062 |
| issn | 1043-1802 1520-4812 |
| language | eng |
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| source | MEDLINE; American Chemical Society Journals |
| subjects | Acids Biochemistry Chromatography, Gel Cytochromes c - chemistry Cytochromes c - metabolism Fullerenes - chemistry Humans Immunoglobulins Malonates - chemistry Models, Molecular Protein Structure, Tertiary Proteins Serum Albumin - chemistry Spectrometry, Fluorescence Spectrometry, Mass, Electrospray Ionization Superoxide Dismutase - chemistry Superoxide Dismutase - metabolism Tromethamine - chemistry Xanthine Oxidase - chemistry Xanthine Oxidase - metabolism |
| title | Formation and Characterization of Stable Human Serum Albumin−Tris-malonic Acid [C60]Fullerene Complex |
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