The Epstein–Barr virus oncoprotein LMP1 inhibits the activity of viral or cellular promoters without inducing cytostasis

The Latent Membrane Protein 1 of the Epstein–Barr virus is required for human B lymphocyte immortalization and functions as a constitutively activated member of the TNF-receptor family, through recruitment of TRAFs and TRADD molecules on its Carboxy-terminal domain, leading to the activation of NF-κ...

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Veröffentlicht in:	Virology (New York, N.Y.) N.Y.), 2006-07, Vol.350 (2), p.381-393
Hauptverfasser:	Narbonnet, Stéphane, Mariamé, Bernard
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, Viral - physiology Base Sequence Burkitt Lymphoma Cell Division Cell Line, Tumor Cytostasis DNA Primers EBV Epstein-Barr virus Exons Genes, Reporter Herpesvirus 4, Human - physiology Humans LMP1 Membrane-spanning domains Promoter Regions, Genetic Promoters Restriction Mapping Reverse Transcriptase Polymerase Chain Reaction Transcription Factors - metabolism Viral Matrix Proteins - genetics Viral Matrix Proteins - physiology
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