Upregulation of ID protein by growth and differentiation factor 5 (GDF5) through a smad-dependent and MAPK-independent pathway in HUVSMC

GDF5 (growth and differentiation factor five), a member of the TGF-β superfamily, binds specifically to BMPR1b, BMPR2 and ACTR2a receptors forming a heterodimeric complex, thereby inducing phosphorylation of smad1, 5, 8 and translocation to the nucleus. ID1 (inhibitor of differentiation or DNA bindi...

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Veröffentlicht in:	Journal of molecular and cellular cardiology 2006-07, Vol.41 (1), p.26-33
Hauptverfasser:	Chen, X., Zankl, A., Niroomand, F., Liu, Z., Katus, H.A., Jahn, L., Tiefenbacher, C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Bone Morphogenetic Proteins - metabolism Bone Morphogenetic Proteins - pharmacology Cell Movement - drug effects Cell Proliferation - drug effects Cells, Cultured Enzyme Inhibitors - pharmacology GDF5 Growth Differentiation Factor 5 Humans ID proteins Inhibitor of Differentiation Protein 1 - drug effects Inhibitor of Differentiation Protein 1 - genetics Inhibitor of Differentiation Protein 1 - metabolism Inhibitor of Differentiation Proteins - drug effects Inhibitor of Differentiation Proteins - genetics Inhibitor of Differentiation Proteins - metabolism Mitogen-Activated Protein Kinases - antagonists & inhibitors Mitogen-Activated Protein Kinases - metabolism Muscle, Smooth, Vascular - cytology Muscle, Smooth, Vascular - metabolism Neovascularization, Physiologic Phosphorylation Protein Transport RNA, Small Interfering Signal Transduction Smad Proteins - metabolism Smad1 Protein - drug effects Smad1 Protein - genetics Smad1 Protein - metabolism TFG-β Transcription, Genetic Up-Regulation Vascular smooth muscle cells
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