Chorioamnionitis is associated with placental transmission of human immunodeficiency virus-1 subtype E in the early gestational period
The frequency and the cellular basis for HIV-1 transmission from mother to child in the early gestational period are poorly understood. We compared the placentas of 24 women seropositive for HIV-1 subtype E and who had not received any antiretroviral drugs, to placentas of 25 seronegative women. All...
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| Veröffentlicht in: | Modern pathology 2005-10, Vol.18 (10), p.1357-1364 |
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| creator | Bhoopat, Lertlakana Khunamornpong, Surapan Sirivatanapa, Pannee Rithaporn, Tat Lerdsrimongkol, Piyaporn Thorner, Paul S Bhoopat, Tanin |
| description | The frequency and the cellular basis for HIV-1 transmission from mother to child in the early gestational period are poorly understood. We compared the placentas of 24 women seropositive for HIV-1 subtype E and who had not received any antiretroviral drugs, to placentas of 25 seronegative women. All placentas were obtained during therapeutic abortion at 6–23 weeks gestation. Placentas and fetal organs were examined by routine light microscopy, immunostaining for p24 capsid protein, and in situ PCR to localize which cells were infected with HIV-1 subtype E. The number of previous abortions was not a factor in placental HIV infection since this number was higher in seronegative women (P |
| doi_str_mv | 10.1038/modpathol.3800418 |
| format | Article |
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We compared the placentas of 24 women seropositive for HIV-1 subtype E and who had not received any antiretroviral drugs, to placentas of 25 seronegative women. All placentas were obtained during therapeutic abortion at 6–23 weeks gestation. Placentas and fetal organs were examined by routine light microscopy, immunostaining for p24 capsid protein, and in situ PCR to localize which cells were infected with HIV-1 subtype E. The number of previous abortions was not a factor in placental HIV infection since this number was higher in seronegative women (P<0.01). There were no significant differences between the placentas of the two groups with respect to presence of chorioamnionitis, villitis, villous stromal fibrosis, infarction, abnormal villous maturation, deciduitis or decidual necrosis. HIV-1 subtype E was detected in up to 83% of placentas, either by immunostaining or in situ PCR, in trophoblast, villous stromal cells, Hofbauer cells, decidual and decidual glandular epithelium. Fetal organs were positive for HIV in 30% (6/20) of cases. There was a significant association between transmission of HIV to the fetus and the histologic findings of chorioamnionitis, plasmacellular deciduitis and decidual cell necrosis. This is the first report showing an association of chorioamnionitis with early in utero transmission of HIV-1 subtype E. This may help explain the cases of in utero transmission that persist despite antiretroviral prophylaxis, given that therapy is started in the late gestational period.</description><identifier>ISSN: 0893-3952</identifier><identifier>EISSN: 1530-0285</identifier><identifier>DOI: 10.1038/modpathol.3800418</identifier><identifier>PMID: 15846390</identifier><identifier>CODEN: MODPEO</identifier><language>eng</language><publisher>New York: Elsevier Inc</publisher><subject>Abortion ; Antiretroviral drugs ; chorioamnionitis ; Chorioamnionitis - etiology ; Chorioamnionitis - virology ; Disease prevention ; Disease transmission ; DNA, Viral - genetics ; Female ; fetal transmission ; Fetuses ; Gestational Age ; HIV ; HIV Core Protein p24 - metabolism ; HIV Infections - transmission ; HIV Infections - virology ; HIV Seronegativity ; HIV Seropositivity - transmission ; HIV Seropositivity - virology ; HIV-1 - classification ; HIV-1 subtype E ; Human immunodeficiency virus ; Humans ; Immune system ; Immunohistochemistry ; Infections ; Infectious Disease Transmission, Vertical ; Laboratory Medicine ; Medicine ; Medicine & Public Health ; Microscopy ; original-article ; Pathology ; Pediatrics ; Placenta ; Placenta - metabolism ; Placenta - pathology ; Placenta - virology ; Pregnancy ; Pregnancy Complications, Infectious - virology ; Proviruses - genetics ; Viral infections</subject><ispartof>Modern pathology, 2005-10, Vol.18 (10), p.1357-1364</ispartof><rights>2005 United States & Canadian Academy of Pathology</rights><rights>United States and Canadian Academy of Pathology, Inc. 2005</rights><rights>Copyright Nature Publishing Group Oct 2005</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c464t-25f3ce83833a6957727c93a250144917dbfb3b939f3a3649854d3412f57280183</citedby><cites>FETCH-LOGICAL-c464t-25f3ce83833a6957727c93a250144917dbfb3b939f3a3649854d3412f57280183</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/221223179?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,64361,64363,64365,72215</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15846390$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bhoopat, Lertlakana</creatorcontrib><creatorcontrib>Khunamornpong, Surapan</creatorcontrib><creatorcontrib>Sirivatanapa, Pannee</creatorcontrib><creatorcontrib>Rithaporn, Tat</creatorcontrib><creatorcontrib>Lerdsrimongkol, Piyaporn</creatorcontrib><creatorcontrib>Thorner, Paul S</creatorcontrib><creatorcontrib>Bhoopat, Tanin</creatorcontrib><title>Chorioamnionitis is associated with placental transmission of human immunodeficiency virus-1 subtype E in the early gestational period</title><title>Modern pathology</title><addtitle>Mod Pathol</addtitle><addtitle>Mod Pathol</addtitle><description>The frequency and the cellular basis for HIV-1 transmission from mother to child in the early gestational period are poorly understood. We compared the placentas of 24 women seropositive for HIV-1 subtype E and who had not received any antiretroviral drugs, to placentas of 25 seronegative women. All placentas were obtained during therapeutic abortion at 6–23 weeks gestation. Placentas and fetal organs were examined by routine light microscopy, immunostaining for p24 capsid protein, and in situ PCR to localize which cells were infected with HIV-1 subtype E. The number of previous abortions was not a factor in placental HIV infection since this number was higher in seronegative women (P<0.01). There were no significant differences between the placentas of the two groups with respect to presence of chorioamnionitis, villitis, villous stromal fibrosis, infarction, abnormal villous maturation, deciduitis or decidual necrosis. HIV-1 subtype E was detected in up to 83% of placentas, either by immunostaining or in situ PCR, in trophoblast, villous stromal cells, Hofbauer cells, decidual and decidual glandular epithelium. Fetal organs were positive for HIV in 30% (6/20) of cases. There was a significant association between transmission of HIV to the fetus and the histologic findings of chorioamnionitis, plasmacellular deciduitis and decidual cell necrosis. This is the first report showing an association of chorioamnionitis with early in utero transmission of HIV-1 subtype E. This may help explain the cases of in utero transmission that persist despite antiretroviral prophylaxis, given that therapy is started in the late gestational period.</description><subject>Abortion</subject><subject>Antiretroviral drugs</subject><subject>chorioamnionitis</subject><subject>Chorioamnionitis - etiology</subject><subject>Chorioamnionitis - virology</subject><subject>Disease prevention</subject><subject>Disease transmission</subject><subject>DNA, Viral - genetics</subject><subject>Female</subject><subject>fetal transmission</subject><subject>Fetuses</subject><subject>Gestational Age</subject><subject>HIV</subject><subject>HIV Core Protein p24 - metabolism</subject><subject>HIV Infections - transmission</subject><subject>HIV Infections - virology</subject><subject>HIV Seronegativity</subject><subject>HIV Seropositivity - transmission</subject><subject>HIV Seropositivity - virology</subject><subject>HIV-1 - classification</subject><subject>HIV-1 subtype E</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>Immune system</subject><subject>Immunohistochemistry</subject><subject>Infections</subject><subject>Infectious Disease Transmission, Vertical</subject><subject>Laboratory Medicine</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Microscopy</subject><subject>original-article</subject><subject>Pathology</subject><subject>Pediatrics</subject><subject>Placenta</subject><subject>Placenta - metabolism</subject><subject>Placenta - pathology</subject><subject>Placenta - virology</subject><subject>Pregnancy</subject><subject>Pregnancy Complications, Infectious - virology</subject><subject>Proviruses - genetics</subject><subject>Viral infections</subject><issn>0893-3952</issn><issn>1530-0285</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kc1u1TAQhS0EoreFB2CDLBbsUvwTJ7ZYoatSkCqxgbXl2JPGVWIH22l1X4DnxnCvqMSi0khezHfOzPgg9IaSS0q4_LBEt5oyxfmSS0JaKp-hHRWcNIRJ8RztiFS84UqwM3Se8x0htBWSvURnVMi244rs0K_9FJOPZgk-Bl98xrVMztF6U8DhB18mvM7GQihmxiWZkBefc6VxHPG0LSZgvyxbiA5Gbz0Ee8D3Pm25oThvQzmsgK-wD7hMgMGk-YBvIRdTqkV1XKGOd6_Qi9HMGV6f3gv04_PV9_2X5ubb9df9p5vGtl1bGiZGbkFyybnplOh71lvFDRP1slbR3g3jwAfF1cgN71olRet4S9koeiYJlfwCvT_6rin-3Ooauh5jYZ5NgLhl3Umheib6Cr77D7yLW6oLZ80YZYzTXlWIHiGbYs4JRr0mv5h00JToPwnpfwnpU0JV8_ZkvA0LuEfFKZIKsCOQayvcQnqc_JTrx6MI6ufd-yrKf6MA5xPYol30T6h_AwD1tdk</recordid><startdate>20051001</startdate><enddate>20051001</enddate><creator>Bhoopat, Lertlakana</creator><creator>Khunamornpong, Surapan</creator><creator>Sirivatanapa, Pannee</creator><creator>Rithaporn, Tat</creator><creator>Lerdsrimongkol, Piyaporn</creator><creator>Thorner, Paul S</creator><creator>Bhoopat, Tanin</creator><general>Elsevier Inc</general><general>Nature Publishing Group US</general><general>Elsevier Limited</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20051001</creationdate><title>Chorioamnionitis is associated with placental transmission of human immunodeficiency virus-1 subtype E in the early gestational period</title><author>Bhoopat, Lertlakana ; Khunamornpong, Surapan ; Sirivatanapa, Pannee ; Rithaporn, Tat ; Lerdsrimongkol, Piyaporn ; Thorner, Paul S ; Bhoopat, Tanin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c464t-25f3ce83833a6957727c93a250144917dbfb3b939f3a3649854d3412f57280183</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Abortion</topic><topic>Antiretroviral drugs</topic><topic>chorioamnionitis</topic><topic>Chorioamnionitis - etiology</topic><topic>Chorioamnionitis - virology</topic><topic>Disease prevention</topic><topic>Disease transmission</topic><topic>DNA, Viral - genetics</topic><topic>Female</topic><topic>fetal transmission</topic><topic>Fetuses</topic><topic>Gestational Age</topic><topic>HIV</topic><topic>HIV Core Protein p24 - metabolism</topic><topic>HIV Infections - transmission</topic><topic>HIV Infections - virology</topic><topic>HIV Seronegativity</topic><topic>HIV Seropositivity - transmission</topic><topic>HIV Seropositivity - virology</topic><topic>HIV-1 - classification</topic><topic>HIV-1 subtype E</topic><topic>Human immunodeficiency virus</topic><topic>Humans</topic><topic>Immune system</topic><topic>Immunohistochemistry</topic><topic>Infections</topic><topic>Infectious Disease Transmission, Vertical</topic><topic>Laboratory Medicine</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Microscopy</topic><topic>original-article</topic><topic>Pathology</topic><topic>Pediatrics</topic><topic>Placenta</topic><topic>Placenta - 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Academic</collection><jtitle>Modern pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bhoopat, Lertlakana</au><au>Khunamornpong, Surapan</au><au>Sirivatanapa, Pannee</au><au>Rithaporn, Tat</au><au>Lerdsrimongkol, Piyaporn</au><au>Thorner, Paul S</au><au>Bhoopat, Tanin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chorioamnionitis is associated with placental transmission of human immunodeficiency virus-1 subtype E in the early gestational period</atitle><jtitle>Modern pathology</jtitle><stitle>Mod Pathol</stitle><addtitle>Mod Pathol</addtitle><date>2005-10-01</date><risdate>2005</risdate><volume>18</volume><issue>10</issue><spage>1357</spage><epage>1364</epage><pages>1357-1364</pages><issn>0893-3952</issn><eissn>1530-0285</eissn><coden>MODPEO</coden><abstract>The frequency and the cellular basis for HIV-1 transmission from mother to child in the early gestational period are poorly understood. We compared the placentas of 24 women seropositive for HIV-1 subtype E and who had not received any antiretroviral drugs, to placentas of 25 seronegative women. All placentas were obtained during therapeutic abortion at 6–23 weeks gestation. Placentas and fetal organs were examined by routine light microscopy, immunostaining for p24 capsid protein, and in situ PCR to localize which cells were infected with HIV-1 subtype E. The number of previous abortions was not a factor in placental HIV infection since this number was higher in seronegative women (P<0.01). There were no significant differences between the placentas of the two groups with respect to presence of chorioamnionitis, villitis, villous stromal fibrosis, infarction, abnormal villous maturation, deciduitis or decidual necrosis. HIV-1 subtype E was detected in up to 83% of placentas, either by immunostaining or in situ PCR, in trophoblast, villous stromal cells, Hofbauer cells, decidual and decidual glandular epithelium. Fetal organs were positive for HIV in 30% (6/20) of cases. There was a significant association between transmission of HIV to the fetus and the histologic findings of chorioamnionitis, plasmacellular deciduitis and decidual cell necrosis. This is the first report showing an association of chorioamnionitis with early in utero transmission of HIV-1 subtype E. This may help explain the cases of in utero transmission that persist despite antiretroviral prophylaxis, given that therapy is started in the late gestational period.</abstract><cop>New York</cop><pub>Elsevier Inc</pub><pmid>15846390</pmid><doi>10.1038/modpathol.3800418</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Abortion Antiretroviral drugs chorioamnionitis Chorioamnionitis - etiology Chorioamnionitis - virology Disease prevention Disease transmission DNA, Viral - genetics Female fetal transmission Fetuses Gestational Age HIV HIV Core Protein p24 - metabolism HIV Infections - transmission HIV Infections - virology HIV Seronegativity HIV Seropositivity - transmission HIV Seropositivity - virology HIV-1 - classification HIV-1 subtype E Human immunodeficiency virus Humans Immune system Immunohistochemistry Infections Infectious Disease Transmission, Vertical Laboratory Medicine Medicine Medicine & Public Health Microscopy original-article Pathology Pediatrics Placenta Placenta - metabolism Placenta - pathology Placenta - virology Pregnancy Pregnancy Complications, Infectious - virology Proviruses - genetics Viral infections |
| title | Chorioamnionitis is associated with placental transmission of human immunodeficiency virus-1 subtype E in the early gestational period |
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