Serum tumor necrosis factor-alpha in pre eclampsia

Cytokines are major contributors in pathogenesis of pre eclampsia. Serum TNF-alpha was determined in 10 normal and 30 pre-eclamptic pregnant females with special reference to maternal age, parity and levels of mean arterial blood pressure. TNF-alpha was determined using sandwich ELISA technique. Ser...

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Veröffentlicht in:	Indian journal of physiology and pharmacology 2005-04, Vol.49 (2), p.236-240
Hauptverfasser:	Muzammil, Sazina, Singhal, Usha, Gulati, Rajiv, Bano, Imam
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Blood Pressure Case-Control Studies Female Humans Maternal Age Parity Pre-Eclampsia - metabolism Pregnancy Pregnancy Trimester, Third Serum - metabolism Tumor Necrosis Factor-alpha - metabolism
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Zusammenfassung:	Cytokines are major contributors in pathogenesis of pre eclampsia. Serum TNF-alpha was determined in 10 normal and 30 pre-eclamptic pregnant females with special reference to maternal age, parity and levels of mean arterial blood pressure. TNF-alpha was determined using sandwich ELISA technique. Serum TNF-alpha level in normal pregnant females was 9.3 +/- 0.56 pg/ml, while in pre-eclamptic pregnant females it was 67.66 +/- 61.83 pg/ml. This increase TNF-alpha was highly significant (P < 0.001). There was no significant changes in serum TNF-alpha with respect to maternal age, parity and mean arterial pressure in both normal and pre-eclamptic pregnancies.
ISSN:	0019-5499