Cloning and characterization of a novel KRAB-domain-containing zinc finger gene (ZNF284L)
The zinc finger gene (ZNF) family plays an important role in the regulation of transcription. This study reports the cloning and characterization of a novel human zinc finger protein cDNA (ZNF284L) from fetal brain cDNA library. The ZNF284L cDNA is 2223 bp in length encoding a 593-aa polypeptide. Th...
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| Veröffentlicht in: | Molecular biology reports 2006-06, Vol.33 (2), p.137-144 |
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| creator | Yin, Gang Ji, Chaoneng Zeng, Li Wang, Zebin Wang, Jiayan Shen, Zhouliang Wu, Tong Gu, Shaohua Xie, Yi Mao, Yumin |
| description | The zinc finger gene (ZNF) family plays an important role in the regulation of transcription. This study reports the cloning and characterization of a novel human zinc finger protein cDNA (ZNF284L) from fetal brain cDNA library. The ZNF284L cDNA is 2223 bp in length encoding a 593-aa polypeptide. The protein contains a KRAB A+b box and eleven C2H2 type zinc finger motifs. ZNF284L gene is mapped to 19q13.2-19q13.3 with 5 exons, and the expression pattern of ZNF284L gene was also examined by reverse transcription polymerase chain reaction (RT-PCR). The transcripts were detected in the human lung, liver, pancreas, thymus, heart, placenta, spleen, prostate, ovary, small intestine and colon, but in human brain, skeletal muscle, kidney, testis and peripheral blood leukocyte, no expression was detected. |
| doi_str_mv | 10.1007/s11033-005-6405-3 |
| format | Article |
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This study reports the cloning and characterization of a novel human zinc finger protein cDNA (ZNF284L) from fetal brain cDNA library. The ZNF284L cDNA is 2223 bp in length encoding a 593-aa polypeptide. The protein contains a KRAB A+b box and eleven C2H2 type zinc finger motifs. ZNF284L gene is mapped to 19q13.2-19q13.3 with 5 exons, and the expression pattern of ZNF284L gene was also examined by reverse transcription polymerase chain reaction (RT-PCR). The transcripts were detected in the human lung, liver, pancreas, thymus, heart, placenta, spleen, prostate, ovary, small intestine and colon, but in human brain, skeletal muscle, kidney, testis and peripheral blood leukocyte, no expression was detected.</description><identifier>ISSN: 0301-4851</identifier><identifier>EISSN: 1573-4978</identifier><identifier>DOI: 10.1007/s11033-005-6405-3</identifier><identifier>PMID: 16817023</identifier><language>eng</language><publisher>Netherlands: Springer Nature B.V</publisher><subject>Amino Acid Sequence ; Base Sequence ; Chromosome 19 ; Cloning ; Cloning, Molecular ; Complementary DNA ; Conserved Sequence ; DNA-Binding Proteins - genetics ; DNA-Binding Proteins - metabolism ; Exons ; Fetuses ; Gene regulation ; Humans ; Molecular Sequence Data ; Peripheral blood ; Polymerase chain reaction ; Prostate ; Protein Structure, Tertiary ; Repressor Proteins - genetics ; Repressor Proteins - metabolism ; Reverse Transcriptase Polymerase Chain Reaction ; Reverse transcription ; RNA, Messenger - metabolism ; Sequence Homology, Amino Acid ; Skeletal muscle ; Small intestine ; Spleen ; Tissue Distribution ; Transcription Factors - genetics ; Transcription Factors - metabolism ; Zinc finger proteins</subject><ispartof>Molecular biology reports, 2006-06, Vol.33 (2), p.137-144</ispartof><rights>Springer 2006.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c385t-8a7ea5dc57da77a1d820bdca92d90fe528017f7bf7f76921e887ee63a1ea3bb93</citedby><cites>FETCH-LOGICAL-c385t-8a7ea5dc57da77a1d820bdca92d90fe528017f7bf7f76921e887ee63a1ea3bb93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16817023$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yin, Gang</creatorcontrib><creatorcontrib>Ji, Chaoneng</creatorcontrib><creatorcontrib>Zeng, Li</creatorcontrib><creatorcontrib>Wang, Zebin</creatorcontrib><creatorcontrib>Wang, Jiayan</creatorcontrib><creatorcontrib>Shen, Zhouliang</creatorcontrib><creatorcontrib>Wu, Tong</creatorcontrib><creatorcontrib>Gu, Shaohua</creatorcontrib><creatorcontrib>Xie, Yi</creatorcontrib><creatorcontrib>Mao, Yumin</creatorcontrib><title>Cloning and characterization of a novel KRAB-domain-containing zinc finger gene (ZNF284L)</title><title>Molecular biology reports</title><addtitle>Mol Biol Rep</addtitle><description>The zinc finger gene (ZNF) family plays an important role in the regulation of transcription. This study reports the cloning and characterization of a novel human zinc finger protein cDNA (ZNF284L) from fetal brain cDNA library. The ZNF284L cDNA is 2223 bp in length encoding a 593-aa polypeptide. The protein contains a KRAB A+b box and eleven C2H2 type zinc finger motifs. ZNF284L gene is mapped to 19q13.2-19q13.3 with 5 exons, and the expression pattern of ZNF284L gene was also examined by reverse transcription polymerase chain reaction (RT-PCR). 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metabolism</subject><subject>Sequence Homology, Amino Acid</subject><subject>Skeletal muscle</subject><subject>Small intestine</subject><subject>Spleen</subject><subject>Tissue Distribution</subject><subject>Transcription Factors - genetics</subject><subject>Transcription Factors - metabolism</subject><subject>Zinc finger proteins</subject><issn>0301-4851</issn><issn>1573-4978</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkU1rFEEQhpsQSTYxP8CLNBGCHlqrpqe_jnExJrgoSHKIl6anpydOmO2O3bOC-fXOsAsBQXKpqsPzVlE8hLxCeI8A6kNBBM4ZgGCyngrfIwsUirPaKL1PFsABWa0FHpKjUu4BoEYlDsghSo0KKr4gt8shxT7eURdb6n-67PwYcv_oxj5FmjrqaEy_w0C_fD__yNq0dn1kPsVx6nPssY-edtMUMr0LMdC3P75eVLpevXtJXnRuKOFk14_JzcWn6-UlW337fLU8XzHPtRiZdio40XqhWqeUw1ZX0LTemao10AVRaUDVqaabijQVBq1VCJI7DI43jeHH5Gy79yGnX5tQRrvuiw_D4GJIm2KlFkZIwZ8F0QgwKHACT_8B79Mmx-kJq-oaJColJujN_6BKGqEqWev5Jm4pn1MpOXT2Ifdrl_9YBDs7tFuHdnJoZ4d2zrzebd4069A-JXbS-F-MrJRz</recordid><startdate>200606</startdate><enddate>200606</enddate><creator>Yin, Gang</creator><creator>Ji, Chaoneng</creator><creator>Zeng, Li</creator><creator>Wang, Zebin</creator><creator>Wang, Jiayan</creator><creator>Shen, Zhouliang</creator><creator>Wu, Tong</creator><creator>Gu, Shaohua</creator><creator>Xie, Yi</creator><creator>Mao, Yumin</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7TM</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>200606</creationdate><title>Cloning and characterization of a novel KRAB-domain-containing zinc finger gene (ZNF284L)</title><author>Yin, Gang ; Ji, Chaoneng ; Zeng, Li ; Wang, Zebin ; Wang, Jiayan ; Shen, Zhouliang ; Wu, Tong ; Gu, Shaohua ; Xie, Yi ; Mao, Yumin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c385t-8a7ea5dc57da77a1d820bdca92d90fe528017f7bf7f76921e887ee63a1ea3bb93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Amino Acid Sequence</topic><topic>Base Sequence</topic><topic>Chromosome 19</topic><topic>Cloning</topic><topic>Cloning, Molecular</topic><topic>Complementary DNA</topic><topic>Conserved Sequence</topic><topic>DNA-Binding Proteins - genetics</topic><topic>DNA-Binding Proteins - metabolism</topic><topic>Exons</topic><topic>Fetuses</topic><topic>Gene regulation</topic><topic>Humans</topic><topic>Molecular Sequence Data</topic><topic>Peripheral blood</topic><topic>Polymerase chain reaction</topic><topic>Prostate</topic><topic>Protein Structure, Tertiary</topic><topic>Repressor Proteins - genetics</topic><topic>Repressor Proteins - metabolism</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>Reverse transcription</topic><topic>RNA, Messenger - metabolism</topic><topic>Sequence Homology, Amino Acid</topic><topic>Skeletal muscle</topic><topic>Small intestine</topic><topic>Spleen</topic><topic>Tissue Distribution</topic><topic>Transcription Factors - genetics</topic><topic>Transcription Factors - metabolism</topic><topic>Zinc finger proteins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yin, Gang</creatorcontrib><creatorcontrib>Ji, Chaoneng</creatorcontrib><creatorcontrib>Zeng, Li</creatorcontrib><creatorcontrib>Wang, Zebin</creatorcontrib><creatorcontrib>Wang, Jiayan</creatorcontrib><creatorcontrib>Shen, Zhouliang</creatorcontrib><creatorcontrib>Wu, Tong</creatorcontrib><creatorcontrib>Gu, Shaohua</creatorcontrib><creatorcontrib>Xie, Yi</creatorcontrib><creatorcontrib>Mao, Yumin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Molecular biology reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yin, Gang</au><au>Ji, Chaoneng</au><au>Zeng, Li</au><au>Wang, Zebin</au><au>Wang, Jiayan</au><au>Shen, Zhouliang</au><au>Wu, Tong</au><au>Gu, Shaohua</au><au>Xie, Yi</au><au>Mao, Yumin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cloning and characterization of a novel KRAB-domain-containing zinc finger gene (ZNF284L)</atitle><jtitle>Molecular biology reports</jtitle><addtitle>Mol Biol Rep</addtitle><date>2006-06</date><risdate>2006</risdate><volume>33</volume><issue>2</issue><spage>137</spage><epage>144</epage><pages>137-144</pages><issn>0301-4851</issn><eissn>1573-4978</eissn><abstract>The zinc finger gene (ZNF) family plays an important role in the regulation of transcription. This study reports the cloning and characterization of a novel human zinc finger protein cDNA (ZNF284L) from fetal brain cDNA library. The ZNF284L cDNA is 2223 bp in length encoding a 593-aa polypeptide. The protein contains a KRAB A+b box and eleven C2H2 type zinc finger motifs. ZNF284L gene is mapped to 19q13.2-19q13.3 with 5 exons, and the expression pattern of ZNF284L gene was also examined by reverse transcription polymerase chain reaction (RT-PCR). The transcripts were detected in the human lung, liver, pancreas, thymus, heart, placenta, spleen, prostate, ovary, small intestine and colon, but in human brain, skeletal muscle, kidney, testis and peripheral blood leukocyte, no expression was detected.</abstract><cop>Netherlands</cop><pub>Springer Nature B.V</pub><pmid>16817023</pmid><doi>10.1007/s11033-005-6405-3</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Amino Acid Sequence Base Sequence Chromosome 19 Cloning Cloning, Molecular Complementary DNA Conserved Sequence DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Exons Fetuses Gene regulation Humans Molecular Sequence Data Peripheral blood Polymerase chain reaction Prostate Protein Structure, Tertiary Repressor Proteins - genetics Repressor Proteins - metabolism Reverse Transcriptase Polymerase Chain Reaction Reverse transcription RNA, Messenger - metabolism Sequence Homology, Amino Acid Skeletal muscle Small intestine Spleen Tissue Distribution Transcription Factors - genetics Transcription Factors - metabolism Zinc finger proteins |
| title | Cloning and characterization of a novel KRAB-domain-containing zinc finger gene (ZNF284L) |
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