Genetic Inhibition or Activation of JNK1/2 Protects the Myocardium from Ischemia-Reperfusion-induced Cell Death in Vivo

The c-Jun NH2-terminal kinase (JNK) branch of the mitogen-activated protein kinase signaling cascade has been implicated in the regulation of apoptosis in a variety of mammalian cell types. In the heart, disagreement persists concerning the role that JNKs may play in regulating apoptosis, since both...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of biological chemistry 2005-09, Vol.280 (38), p.32602-32608
Hauptverfasser:	Kaiser, Robert A., Liang, Qiangrong, Bueno, Orlando, Huang, Yuan, Lackey, Troy, Klevitsky, Raisa, Hewett, Timothy E., Molkentin, Jeffery D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Blotting, Western Cell Death Cell Size Echocardiography Heart - anatomy & histology In Situ Nick-End Labeling MAP Kinase Kinase 7 - biosynthesis MAP Kinase Kinase 7 - genetics MAP Kinase Signaling System Mice Mice, Inbred C57BL Mice, Transgenic Mitogen-Activated Protein Kinase 8 - genetics Mitogen-Activated Protein Kinase 8 - metabolism Mitogen-Activated Protein Kinase 9 - genetics Mitogen-Activated Protein Kinase 9 - metabolism Myocardium - enzymology Phosphorylation Reperfusion Injury Serine - chemistry Time Factors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!