The role of the liver in lipid metabolism during cold acclimation in non-hibernator rodents
Cold exposure increases the demand for energy substrates. Cold acclimation of rats led to a 3-fold increase in fatty acid (FA) β-oxidation ( P < 0.01) for ex vivo livers perfused at 37 °C. This increase was preserved following perfusion at 25 °C ( P < 0.001). In vitro measurement of absolute r...
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| Veröffentlicht in: | Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology 2006-07, Vol.144 (3), p.372-381 |
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| container_title | Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology |
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| creator | Hauton, David Richards, Simon B. Egginton, Stuart |
| description | Cold exposure increases the demand for energy substrates. Cold acclimation of rats led to a 3-fold increase in fatty acid (FA) β-oxidation (
P
<
0.01) for ex vivo livers perfused at 37 °C. This increase was preserved following perfusion at 25 °C (
P
<
0.001). In vitro measurement of absolute rates of hepatic β-oxidation revealed no significant difference following cold acclimation, implying changes in fatty acid flux through β-oxidation rather than increased oxidation capacity. Total FA uptake was increased one-third following perfusion at 25 °C (
P
<
0.001) and cold acclimation (
P
<
0.05) and cold acclimation led to diversion of tissue FA from storage to β-oxidation (
P
<
0.01). In separate experiments, in vivo hepatic lipogenesis rates for saponifiable lipids doubled (
P
<
0.01) and cholesterol synthesis increased one-third (
P
<
0.001). Taken together these data suggest the oxidation and synthesis of lipids occur simultaneously in hepatic tissue possibly to increase prevailing tissue FA concentrations and to generate heat through increased metabolic flux rates. |
| doi_str_mv | 10.1016/j.cbpb.2006.03.013 |
| format | Article |
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P
<
0.01) for ex vivo livers perfused at 37 °C. This increase was preserved following perfusion at 25 °C (
P
<
0.001). In vitro measurement of absolute rates of hepatic β-oxidation revealed no significant difference following cold acclimation, implying changes in fatty acid flux through β-oxidation rather than increased oxidation capacity. Total FA uptake was increased one-third following perfusion at 25 °C (
P
<
0.001) and cold acclimation (
P
<
0.05) and cold acclimation led to diversion of tissue FA from storage to β-oxidation (
P
<
0.01). In separate experiments, in vivo hepatic lipogenesis rates for saponifiable lipids doubled (
P
<
0.01) and cholesterol synthesis increased one-third (
P
<
0.001). Taken together these data suggest the oxidation and synthesis of lipids occur simultaneously in hepatic tissue possibly to increase prevailing tissue FA concentrations and to generate heat through increased metabolic flux rates.]]></description><identifier>ISSN: 1096-4959</identifier><identifier>EISSN: 1879-1107</identifier><identifier>DOI: 10.1016/j.cbpb.2006.03.013</identifier><identifier>PMID: 16730468</identifier><language>eng</language><publisher>England: Elsevier Inc</publisher><subject>Acclimatization - physiology ; Adipocytes - metabolism ; Animals ; Cold acclimation ; Cold Temperature ; Fatty acid oxidation ; Hibernation - physiology ; Lipid Metabolism - physiology ; Lipogenesis ; Liver - physiology ; Liver - ultrastructure ; Liver metabolism ; Male ; Photoperiod ; Rats ; Rats, Sprague-Dawley ; Seasons</subject><ispartof>Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 2006-07, Vol.144 (3), p.372-381</ispartof><rights>2006 Elsevier Inc</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c354t-1d1bd05cf9a1c86e685c244a65ca18c5756e46195cf92d0bd1326d8c99baf443</citedby><cites>FETCH-LOGICAL-c354t-1d1bd05cf9a1c86e685c244a65ca18c5756e46195cf92d0bd1326d8c99baf443</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.cbpb.2006.03.013$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16730468$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hauton, David</creatorcontrib><creatorcontrib>Richards, Simon B.</creatorcontrib><creatorcontrib>Egginton, Stuart</creatorcontrib><title>The role of the liver in lipid metabolism during cold acclimation in non-hibernator rodents</title><title>Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology</title><addtitle>Comp Biochem Physiol B Biochem Mol Biol</addtitle><description><![CDATA[Cold exposure increases the demand for energy substrates. Cold acclimation of rats led to a 3-fold increase in fatty acid (FA) β-oxidation (
P
<
0.01) for ex vivo livers perfused at 37 °C. This increase was preserved following perfusion at 25 °C (
P
<
0.001). In vitro measurement of absolute rates of hepatic β-oxidation revealed no significant difference following cold acclimation, implying changes in fatty acid flux through β-oxidation rather than increased oxidation capacity. Total FA uptake was increased one-third following perfusion at 25 °C (
P
<
0.001) and cold acclimation (
P
<
0.05) and cold acclimation led to diversion of tissue FA from storage to β-oxidation (
P
<
0.01). In separate experiments, in vivo hepatic lipogenesis rates for saponifiable lipids doubled (
P
<
0.01) and cholesterol synthesis increased one-third (
P
<
0.001). Taken together these data suggest the oxidation and synthesis of lipids occur simultaneously in hepatic tissue possibly to increase prevailing tissue FA concentrations and to generate heat through increased metabolic flux rates.]]></description><subject>Acclimatization - physiology</subject><subject>Adipocytes - metabolism</subject><subject>Animals</subject><subject>Cold acclimation</subject><subject>Cold Temperature</subject><subject>Fatty acid oxidation</subject><subject>Hibernation - physiology</subject><subject>Lipid Metabolism - physiology</subject><subject>Lipogenesis</subject><subject>Liver - physiology</subject><subject>Liver - ultrastructure</subject><subject>Liver metabolism</subject><subject>Male</subject><subject>Photoperiod</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Seasons</subject><issn>1096-4959</issn><issn>1879-1107</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLxDAUhYMovv-AC-nKXWtuk2YacCPiCwbczM5FSJNbzdAmY9IR_PemzIA7V_csvvPBPYRcAa2AgrhdV6bbdFVNqagoqyiwA3IK7UKWAHRxmDOVouSykSfkLKU1pawFBsfkBMSCUS7aU_K--sQihgGL0BdTzoP7xlg4n8PG2WLESXdhcGks7DY6_1GYMNhCGzO4UU8u-Jn1wZefrsPo9RRi9ln0U7ogR70eEl7u7zlZPT2uHl7K5dvz68P9sjSs4VMJFjpLG9NLDaYVKNrG1Jxr0RgNrWkWjUAuQM5EbWlngdXCtkbKTvecs3Nys9NuYvjaYprU6JLBYdAewzap7JO8FiyD9Q40MaQUsVebmJ-IPwqomhdVazUvquZFFWUqL5pL13v7thvR_lX2E2bgbgdgfvHbYVTJOPQGrYtoJmWD-8__C4tyh-I</recordid><startdate>20060701</startdate><enddate>20060701</enddate><creator>Hauton, David</creator><creator>Richards, Simon B.</creator><creator>Egginton, Stuart</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20060701</creationdate><title>The role of the liver in lipid metabolism during cold acclimation in non-hibernator rodents</title><author>Hauton, David ; Richards, Simon B. ; Egginton, Stuart</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c354t-1d1bd05cf9a1c86e685c244a65ca18c5756e46195cf92d0bd1326d8c99baf443</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Acclimatization - physiology</topic><topic>Adipocytes - metabolism</topic><topic>Animals</topic><topic>Cold acclimation</topic><topic>Cold Temperature</topic><topic>Fatty acid oxidation</topic><topic>Hibernation - physiology</topic><topic>Lipid Metabolism - physiology</topic><topic>Lipogenesis</topic><topic>Liver - physiology</topic><topic>Liver - ultrastructure</topic><topic>Liver metabolism</topic><topic>Male</topic><topic>Photoperiod</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Seasons</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hauton, David</creatorcontrib><creatorcontrib>Richards, Simon B.</creatorcontrib><creatorcontrib>Egginton, Stuart</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hauton, David</au><au>Richards, Simon B.</au><au>Egginton, Stuart</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The role of the liver in lipid metabolism during cold acclimation in non-hibernator rodents</atitle><jtitle>Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology</jtitle><addtitle>Comp Biochem Physiol B Biochem Mol Biol</addtitle><date>2006-07-01</date><risdate>2006</risdate><volume>144</volume><issue>3</issue><spage>372</spage><epage>381</epage><pages>372-381</pages><issn>1096-4959</issn><eissn>1879-1107</eissn><abstract><![CDATA[Cold exposure increases the demand for energy substrates. Cold acclimation of rats led to a 3-fold increase in fatty acid (FA) β-oxidation (
P
<
0.01) for ex vivo livers perfused at 37 °C. This increase was preserved following perfusion at 25 °C (
P
<
0.001). In vitro measurement of absolute rates of hepatic β-oxidation revealed no significant difference following cold acclimation, implying changes in fatty acid flux through β-oxidation rather than increased oxidation capacity. Total FA uptake was increased one-third following perfusion at 25 °C (
P
<
0.001) and cold acclimation (
P
<
0.05) and cold acclimation led to diversion of tissue FA from storage to β-oxidation (
P
<
0.01). In separate experiments, in vivo hepatic lipogenesis rates for saponifiable lipids doubled (
P
<
0.01) and cholesterol synthesis increased one-third (
P
<
0.001). Taken together these data suggest the oxidation and synthesis of lipids occur simultaneously in hepatic tissue possibly to increase prevailing tissue FA concentrations and to generate heat through increased metabolic flux rates.]]></abstract><cop>England</cop><pub>Elsevier Inc</pub><pmid>16730468</pmid><doi>10.1016/j.cbpb.2006.03.013</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 2006-07, Vol.144 (3), p.372-381 |
| issn | 1096-4959 1879-1107 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Acclimatization - physiology Adipocytes - metabolism Animals Cold acclimation Cold Temperature Fatty acid oxidation Hibernation - physiology Lipid Metabolism - physiology Lipogenesis Liver - physiology Liver - ultrastructure Liver metabolism Male Photoperiod Rats Rats, Sprague-Dawley Seasons |
| title | The role of the liver in lipid metabolism during cold acclimation in non-hibernator rodents |
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