Elevated mutation rates in the germline of Polkappa mutant male mice
Mutation rates at two expanded simple tandem repeat (ESTR) loci were studied in the germline of DNA polymerase kappa (Polkappa(-/-)) deficient mice. The spontaneous mutation rate in homozygous Polkappa(-/-) males was significantly higher than in isogenic wild-type mice (Polkappa(+/+)), but the ESTR...
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| Veröffentlicht in: | DNA repair 2006-07, Vol.5 (7), p.860-862 |
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| creator | Burr, Karen L-A Velasco-Miguel, Susana Duvvuri, Venkata S McDaniel, Lisa D Friedberg, Errol C Dubrova, Yuri E |
| description | Mutation rates at two expanded simple tandem repeat (ESTR) loci were studied in the germline of DNA polymerase kappa (Polkappa(-/-)) deficient mice. The spontaneous mutation rate in homozygous Polkappa(-/-) males was significantly higher than in isogenic wild-type mice (Polkappa(+/+)), but the ESTR mutation spectrum in Polkappa(-/-) animals did not differ from that in Polkappa(+/+) males. We suggest that compromised translesion synthesis in Polkappa(-/-) mice may result in replication fork pausing which, in turn, may affect ESTR mutation rate. |
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The spontaneous mutation rate in homozygous Polkappa(-/-) males was significantly higher than in isogenic wild-type mice (Polkappa(+/+)), but the ESTR mutation spectrum in Polkappa(-/-) animals did not differ from that in Polkappa(+/+) males. 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The spontaneous mutation rate in homozygous Polkappa(-/-) males was significantly higher than in isogenic wild-type mice (Polkappa(+/+)), but the ESTR mutation spectrum in Polkappa(-/-) animals did not differ from that in Polkappa(+/+) males. We suggest that compromised translesion synthesis in Polkappa(-/-) mice may result in replication fork pausing which, in turn, may affect ESTR mutation rate.</description><subject>Animals</subject><subject>DNA Damage</subject><subject>DNA Repair - genetics</subject><subject>DNA-Directed DNA Polymerase - deficiency</subject><subject>DNA-Directed DNA Polymerase - genetics</subject><subject>Germ-Line Mutation</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mice, Knockout</subject><subject>Minisatellite Repeats</subject><issn>1568-7864</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1j81KxDAYRbNQnHH0FSQrd4Wk-e1SxlEHBnQx-5KkXzWatDVJBd_eouPqcuGcC_cMramQulJa8hW6zPmdECqUlBdoRaVilAi2Rve7AF-mQIfjXEzx44DTUjP2Ay5vgF8hxeAHwGOPX8bwYabJ_KJDwdEEwNE7uELnvQkZrk-5QceH3XH7VB2eH_fbu0M1Cc6qvhYclOWdZhwIVUY3tXO1kMQR5SznwIS2klPdcGIpt6qXhnWcEKOJBsE26PZvdkrj5wy5tNFnByGYAcY5t1KLxZTNAt6cwNlG6Nop-WjSd_t_m_0ARHhRmg</recordid><startdate>20060713</startdate><enddate>20060713</enddate><creator>Burr, Karen L-A</creator><creator>Velasco-Miguel, Susana</creator><creator>Duvvuri, Venkata S</creator><creator>McDaniel, Lisa D</creator><creator>Friedberg, Errol C</creator><creator>Dubrova, Yuri E</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20060713</creationdate><title>Elevated mutation rates in the germline of Polkappa mutant male mice</title><author>Burr, Karen L-A ; Velasco-Miguel, Susana ; Duvvuri, Venkata S ; McDaniel, Lisa D ; Friedberg, Errol C ; Dubrova, Yuri E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p543-f254e7b4d834e017a892cc2560c07cb44e358b6418940b14b7f6a3d400a808e53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Animals</topic><topic>DNA Damage</topic><topic>DNA Repair - genetics</topic><topic>DNA-Directed DNA Polymerase - deficiency</topic><topic>DNA-Directed DNA Polymerase - genetics</topic><topic>Germ-Line Mutation</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Mice, Knockout</topic><topic>Minisatellite Repeats</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Burr, Karen L-A</creatorcontrib><creatorcontrib>Velasco-Miguel, Susana</creatorcontrib><creatorcontrib>Duvvuri, Venkata S</creatorcontrib><creatorcontrib>McDaniel, Lisa D</creatorcontrib><creatorcontrib>Friedberg, Errol C</creatorcontrib><creatorcontrib>Dubrova, Yuri E</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>DNA repair</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Burr, Karen L-A</au><au>Velasco-Miguel, Susana</au><au>Duvvuri, Venkata S</au><au>McDaniel, Lisa D</au><au>Friedberg, Errol C</au><au>Dubrova, Yuri E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Elevated mutation rates in the germline of Polkappa mutant male mice</atitle><jtitle>DNA repair</jtitle><addtitle>DNA Repair (Amst)</addtitle><date>2006-07-13</date><risdate>2006</risdate><volume>5</volume><issue>7</issue><spage>860</spage><epage>862</epage><pages>860-862</pages><issn>1568-7864</issn><abstract>Mutation rates at two expanded simple tandem repeat (ESTR) loci were studied in the germline of DNA polymerase kappa (Polkappa(-/-)) deficient mice. The spontaneous mutation rate in homozygous Polkappa(-/-) males was significantly higher than in isogenic wild-type mice (Polkappa(+/+)), but the ESTR mutation spectrum in Polkappa(-/-) animals did not differ from that in Polkappa(+/+) males. We suggest that compromised translesion synthesis in Polkappa(-/-) mice may result in replication fork pausing which, in turn, may affect ESTR mutation rate.</abstract><cop>Netherlands</cop><pmid>16731053</pmid><tpages>3</tpages></addata></record> |
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| ispartof | DNA repair, 2006-07, Vol.5 (7), p.860-862 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals DNA Damage DNA Repair - genetics DNA-Directed DNA Polymerase - deficiency DNA-Directed DNA Polymerase - genetics Germ-Line Mutation Male Mice Mice, Inbred BALB C Mice, Knockout Minisatellite Repeats |
| title | Elevated mutation rates in the germline of Polkappa mutant male mice |
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