Differential expression of human granzymes A, B, and K in natural killer cells and during CD8+ T cell differentiation in peripheral blood

NK cells and cytotoxic T lymphocytes can induce apoptosis in virus‐infected and transformed target cells via the granule exocytosis pathway. The key components of the cytolytic granules are perforin and several serine esterases, termed granzymes. While the cellular distribution of human granzymes A...

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Veröffentlicht in:	European journal of immunology 2005-09, Vol.35 (9), p.2608-2616
Hauptverfasser:	Bratke, Kai, Kuepper, Michael, Bade, Britta, Virchow, J. Christian, Luttmann, Werner
Format:	Artikel
Sprache:	eng
Schlagworte:	CD11b Antigen - biosynthesis CD11b Antigen - genetics CD11b Antigen - immunology CD28 Antigens - immunology CD8-Positive T-Lymphocytes - cytology CD8-Positive T-Lymphocytes - enzymology CD8-Positive T-Lymphocytes - immunology Cytokines - biosynthesis Cytokines - genetics Cytokines - immunology Cytotoxic T lymphocytes Flow Cytometry Gene Expression Regulation - immunology Granzyme Granzymes HLA-DR Antigens - biosynthesis HLA-DR Antigens - genetics HLA-DR Antigens - immunology Humans Immunophenotyping Killer Cells, Natural - cytology Killer Cells, Natural - enzymology Killer Cells, Natural - immunology Membrane Glycoproteins - biosynthesis Membrane Glycoproteins - genetics Membrane Glycoproteins - immunology Memory T cell Natural killer cell Perforin Pore Forming Cytotoxic Proteins Receptors, CCR5 - immunology Serine Endopeptidases - biosynthesis Serine Endopeptidases - genetics Serine Endopeptidases - immunology T-Lymphocyte Subsets - immunology Tumor Necrosis Factor Receptor Superfamily, Member 7 - immunology
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