Progesterone restores retrograde labeling of cervical motoneurons in Wobbler mouse motoneuron disease

The Wobbler mouse, a mutant characterized by motoneuron degeneration in the cervical spinal cord, has been used to test the efficacy of novel treatments for human motoneuron diseases (HMD). Previous reports have shown that slow axonal transport is impaired in Wobblers and other models of HMD. Since...

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Veröffentlicht in:	Experimental neurology 2005-10, Vol.195 (2), p.518-523
Hauptverfasser:	Gonzalez Deniselle, Maria Claudia, Garay, Laura, Gonzalez, Susana, Guennoun, Rachida, Schumacher, Michael, De Nicola, Alejandro F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Axonal transport Axonal Transport - drug effects Behavior, Animal Biological and medical sciences Cervical Vertebrae - pathology Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Disease Models, Animal Female Fluorogold Male Medical sciences Mice Mice, Neurologic Mutants Motoneuron degeneration Motor Neuron Disease - drug therapy Motor Neuron Disease - physiopathology Motor Neurons - drug effects Neurology Orthopedic surgery Progesterone Progestins - blood Progestins - therapeutic use Spinal cord Spinal Cord - pathology Stilbamidines - metabolism Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Upper Extremity - physiopathology Wobbler mouse
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