On the Synthesis of Bioisosters of O-Benzothiazolyloxybenzoic Acids and Evaluation as Aldose Reductase Inhibitors
In continuation of our attempts to develop novel aldose reductase inhibitors (ARIs), a number of compounds characterized by bioisosteric replacement of pharmacophors were prepared. On the one hand, the acidic function was formally replaced by an oxime or a nitro group and on the other hand the lipop...
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| Veröffentlicht in: | Archiv der Pharmazie (Weinheim) 2005-09, Vol.338 (9), p.419-426 |
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| container_end_page | 426 |
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| container_issue | 9 |
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| container_title | Archiv der Pharmazie (Weinheim) |
| container_volume | 338 |
| creator | Rakowitz, Dietmar Muigg, Patric Schröder, Nicole Matuszczak, Barbara |
| description | In continuation of our attempts to develop novel aldose reductase inhibitors (ARIs), a number of compounds characterized by bioisosteric replacement of pharmacophors were prepared. On the one hand, the acidic function was formally replaced by an oxime or a nitro group and on the other hand the lipophilic substituent was modified. The results of the biological evaluation of these derivatives enabled us to gain insight into structural features critical for the aldose reductase inhibition. |
| doi_str_mv | 10.1002/ardp.200500119 |
| format | Article |
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The results of the biological evaluation of these derivatives enabled us to gain insight into structural features critical for the aldose reductase inhibition.</description><subject>Aldehyde Reductase - antagonists & inhibitors</subject><subject>Aldose reductase inhibitors</subject><subject>Animals</subject><subject>Benzoates - chemical synthesis</subject><subject>Benzoates - chemistry</subject><subject>Bioisosteric replacement</subject><subject>Biological and medical sciences</subject><subject>Cattle</subject><subject>Diabetic complications</subject><subject>Enzyme inhibitors</subject><subject>Enzyme Inhibitors - chemical synthesis</subject><subject>Enzyme Inhibitors - chemistry</subject><subject>General and cellular metabolism. Vitamins</subject><subject>In Vitro Techniques</subject><subject>Lens, Crystalline - enzymology</subject><subject>Medical sciences</subject><subject>Molecular Structure</subject><subject>Pharmacology. 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| fulltext | fulltext |
| identifier | ISSN: 0365-6233 |
| ispartof | Archiv der Pharmazie (Weinheim), 2005-09, Vol.338 (9), p.419-426 |
| issn | 0365-6233 1521-4184 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Aldehyde Reductase - antagonists & inhibitors Aldose reductase inhibitors Animals Benzoates - chemical synthesis Benzoates - chemistry Bioisosteric replacement Biological and medical sciences Cattle Diabetic complications Enzyme inhibitors Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - chemistry General and cellular metabolism. Vitamins In Vitro Techniques Lens, Crystalline - enzymology Medical sciences Molecular Structure Pharmacology. Drug treatments Structure-Activity Relationship Thiazoles - chemical synthesis Thiazoles - chemistry |
| title | On the Synthesis of Bioisosters of O-Benzothiazolyloxybenzoic Acids and Evaluation as Aldose Reductase Inhibitors |
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