Intrahepatic immunity: a tale of two sites?

The intrahepatic immune environment is associated with the induction of tolerance, yet maintains the capacity to sustain effective responses against pathogens. The mechanisms underlying this dichotomy are unclear. Recent data indicate that activation of naïve CD8 + T cells occurs within the liver. H...

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Veröffentlicht in:	Trends in Immunology 2005-10, Vol.26 (10), p.512-517
Hauptverfasser:	Bowen, David G., McCaughan, Geoffrey W., Bertolino, Patrick
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigen Presentation - immunology Apoptosis CD8-Positive T-Lymphocytes - immunology Endothelium Hepatitis - immunology Hepatitis - prevention & control Hypotheses Immune system Immune Tolerance - immunology Liver - immunology Lymph Nodes - immunology Lymphocytes Models, Immunological Peptides Rodents T cell receptors T-Lymphocytes - immunology Transplants & implants
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