Intrahepatic immunity: a tale of two sites?
The intrahepatic immune environment is associated with the induction of tolerance, yet maintains the capacity to sustain effective responses against pathogens. The mechanisms underlying this dichotomy are unclear. Recent data indicate that activation of naïve CD8 + T cells occurs within the liver. H...
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| Veröffentlicht in: | Trends in Immunology 2005-10, Vol.26 (10), p.512-517 |
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| creator | Bowen, David G. McCaughan, Geoffrey W. Bertolino, Patrick |
| description | The intrahepatic immune environment is associated with the induction of tolerance, yet maintains the capacity to sustain effective responses against pathogens. The mechanisms underlying this dichotomy are unclear. Recent data indicate that activation of naïve CD8
+ T cells occurs within the liver. However, in contrast to efficient primary activation observed within the lymph nodes, this pathway is relatively ineffective, leading to reduced CD8
+ T-cell cytotoxicity and survival. Thus, the outcome of intrahepatic CD8
+ T-cell responses might be determined by whether primary activation occurs within the tolerogenic environment of the liver, or whether immunity is induced by initial antigen encounter within the lymph nodes. These findings support a novel model of hepatic–immune interactions, with implications for our understanding of the paradoxical nature of liver immunobiology. |
| doi_str_mv | 10.1016/j.it.2005.08.005 |
| format | Article |
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+ T-cell cytotoxicity and survival. Thus, the outcome of intrahepatic CD8
+ T-cell responses might be determined by whether primary activation occurs within the tolerogenic environment of the liver, or whether immunity is induced by initial antigen encounter within the lymph nodes. These findings support a novel model of hepatic–immune interactions, with implications for our understanding of the paradoxical nature of liver immunobiology.</description><identifier>ISSN: 1471-4906</identifier><identifier>EISSN: 1471-4981</identifier><identifier>EISSN: 1365-2567</identifier><identifier>DOI: 10.1016/j.it.2005.08.005</identifier><identifier>PMID: 16109501</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Animals ; Antigen Presentation - immunology ; Apoptosis ; CD8-Positive T-Lymphocytes - immunology ; Endothelium ; Hepatitis - immunology ; Hepatitis - prevention & control ; Hypotheses ; Immune system ; Immune Tolerance - immunology ; Liver - immunology ; Lymph Nodes - immunology ; Lymphocytes ; Models, Immunological ; Peptides ; Rodents ; T cell receptors ; T-Lymphocytes - immunology ; Transplants & implants</subject><ispartof>Trends in Immunology, 2005-10, Vol.26 (10), p.512-517</ispartof><rights>2005 Elsevier Ltd</rights><rights>Copyright Elsevier Limited Oct 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c473t-eb86825367639237adf91ad8c01979ceb2182da57452d7ff38d2d9522415091b3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.it.2005.08.005$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16109501$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bowen, David G.</creatorcontrib><creatorcontrib>McCaughan, Geoffrey W.</creatorcontrib><creatorcontrib>Bertolino, Patrick</creatorcontrib><title>Intrahepatic immunity: a tale of two sites?</title><title>Trends in Immunology</title><addtitle>Trends Immunol</addtitle><description>The intrahepatic immune environment is associated with the induction of tolerance, yet maintains the capacity to sustain effective responses against pathogens. The mechanisms underlying this dichotomy are unclear. Recent data indicate that activation of naïve CD8
+ T cells occurs within the liver. However, in contrast to efficient primary activation observed within the lymph nodes, this pathway is relatively ineffective, leading to reduced CD8
+ T-cell cytotoxicity and survival. Thus, the outcome of intrahepatic CD8
+ T-cell responses might be determined by whether primary activation occurs within the tolerogenic environment of the liver, or whether immunity is induced by initial antigen encounter within the lymph nodes. These findings support a novel model of hepatic–immune interactions, with implications for our understanding of the paradoxical nature of liver immunobiology.</description><subject>Animals</subject><subject>Antigen Presentation - immunology</subject><subject>Apoptosis</subject><subject>CD8-Positive T-Lymphocytes - immunology</subject><subject>Endothelium</subject><subject>Hepatitis - immunology</subject><subject>Hepatitis - prevention & control</subject><subject>Hypotheses</subject><subject>Immune system</subject><subject>Immune Tolerance - immunology</subject><subject>Liver - immunology</subject><subject>Lymph Nodes - immunology</subject><subject>Lymphocytes</subject><subject>Models, Immunological</subject><subject>Peptides</subject><subject>Rodents</subject><subject>T cell receptors</subject><subject>T-Lymphocytes - immunology</subject><subject>Transplants & implants</subject><issn>1471-4906</issn><issn>1471-4981</issn><issn>1365-2567</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM1LHEEQxZsQibrJ3VMYCHiRHau6p7-8iIhGQfBizk1vdw_pZWdm091j8L-3ZZcEhJBLvTr86lXVI-QEoUVAcb5uY2kpAG9BtVU-kCPsJC47rfDjnx7EITnOeQ2AXEr5iRyiQNAc8Iic3Y8l2Z9ha0t0TRyGeYzl5aKxTbGb0Ex9U35PTY4l5MvP5KC3mxy-7HVBftzePF3fLR8ev99fXz0sXSdZWYaVEopyJqRgmjJpfa_ReuUAtdQurCgq6i2XHade9j1TnnrNKe2Qg8YVW5DTne82Tb_mkIsZYnZhs7FjmOZshOIaNND_giiZErzWBfn2DlxPcxrrE6buFJoBqwcvCOwol6acU-jNNsXBpheDYN7yNmsTi3nL24AyVerI173xvBqC_zuwD7gCFzsg1MCeY0gmuxhGF3xMwRXjp_hv91eXZ4vH</recordid><startdate>20051001</startdate><enddate>20051001</enddate><creator>Bowen, David G.</creator><creator>McCaughan, Geoffrey W.</creator><creator>Bertolino, Patrick</creator><general>Elsevier Ltd</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20051001</creationdate><title>Intrahepatic immunity: a tale of two sites?</title><author>Bowen, David G. ; McCaughan, Geoffrey W. ; Bertolino, Patrick</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c473t-eb86825367639237adf91ad8c01979ceb2182da57452d7ff38d2d9522415091b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Animals</topic><topic>Antigen Presentation - immunology</topic><topic>Apoptosis</topic><topic>CD8-Positive T-Lymphocytes - immunology</topic><topic>Endothelium</topic><topic>Hepatitis - immunology</topic><topic>Hepatitis - prevention & control</topic><topic>Hypotheses</topic><topic>Immune system</topic><topic>Immune Tolerance - immunology</topic><topic>Liver - immunology</topic><topic>Lymph Nodes - immunology</topic><topic>Lymphocytes</topic><topic>Models, Immunological</topic><topic>Peptides</topic><topic>Rodents</topic><topic>T cell receptors</topic><topic>T-Lymphocytes - immunology</topic><topic>Transplants & implants</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bowen, David G.</creatorcontrib><creatorcontrib>McCaughan, Geoffrey W.</creatorcontrib><creatorcontrib>Bertolino, Patrick</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Trends in Immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bowen, David G.</au><au>McCaughan, Geoffrey W.</au><au>Bertolino, Patrick</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intrahepatic immunity: a tale of two sites?</atitle><jtitle>Trends in Immunology</jtitle><addtitle>Trends Immunol</addtitle><date>2005-10-01</date><risdate>2005</risdate><volume>26</volume><issue>10</issue><spage>512</spage><epage>517</epage><pages>512-517</pages><issn>1471-4906</issn><eissn>1471-4981</eissn><eissn>1365-2567</eissn><abstract>The intrahepatic immune environment is associated with the induction of tolerance, yet maintains the capacity to sustain effective responses against pathogens. The mechanisms underlying this dichotomy are unclear. Recent data indicate that activation of naïve CD8
+ T cells occurs within the liver. However, in contrast to efficient primary activation observed within the lymph nodes, this pathway is relatively ineffective, leading to reduced CD8
+ T-cell cytotoxicity and survival. Thus, the outcome of intrahepatic CD8
+ T-cell responses might be determined by whether primary activation occurs within the tolerogenic environment of the liver, or whether immunity is induced by initial antigen encounter within the lymph nodes. These findings support a novel model of hepatic–immune interactions, with implications for our understanding of the paradoxical nature of liver immunobiology.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>16109501</pmid><doi>10.1016/j.it.2005.08.005</doi><tpages>6</tpages></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Wiley Free Content; ScienceDirect Journals (5 years ago - present); IngentaConnect Free/Open Access Journals; Wiley Online Library All Journals; PubMed Central |
| subjects | Animals Antigen Presentation - immunology Apoptosis CD8-Positive T-Lymphocytes - immunology Endothelium Hepatitis - immunology Hepatitis - prevention & control Hypotheses Immune system Immune Tolerance - immunology Liver - immunology Lymph Nodes - immunology Lymphocytes Models, Immunological Peptides Rodents T cell receptors T-Lymphocytes - immunology Transplants & implants |
| title | Intrahepatic immunity: a tale of two sites? |
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