Prognostic value of the Duke Treadmill Score in diabetic patients
The Duke Treadmill Score (DTS) is an established clinical tool for risk stratification of coronary artery disease. We sought to assess the prognostic value of the DTS in diabetics compared with nondiabetics in this study. We studied 100 diabetics and 202 age- and sex-matched nondiabetic controls wit...
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| Veröffentlicht in: | The American heart journal 2005-09, Vol.150 (3), p.516-521 |
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| creator | Lakkireddy, Dhanunjaya R. Bhakkad, Jyothi Korlakunta, Hema L. Ryschon, Kay Shen, Xuedong Mooss, Aryan N. Mohiuddin, Syed M. |
| description | The Duke Treadmill Score (DTS) is an established clinical tool for risk stratification of coronary artery disease. We sought to assess the prognostic value of the DTS in diabetics compared with nondiabetics in this study.
We studied 100 diabetics and 202 age- and sex-matched nondiabetic controls without known coronary artery disease risk stratified by DTS and followed for a median duration of 6.6 years. The association between DTS and primary, secondary outcomes, composite events, and rate of coronary angiography was tested.
Survival free from cardiac death, nonfatal myocardial infarction, congestive heart failure, or early and late revascularization was 89%, 54%, and 13%, respectively, in the low-, intermediate-, and high-risk categories of diabetic group (
P < .0001), and 91%, 57%, and 17%, respectively, in the low- to high-risk groups of nondiabetics (
P < .0001). During follow-up, diabetics had more secondary events (
P = .011) and coronary angiography (
P < .001) compared with nondiabetics. The DTS was a strong independent predictor of composite events in both diabetics (
P < .001) and nondiabetics (
P < .001). A significant number of diabetics were classified as intermediate risk and had a significantly higher incidence of coronary angiography (87.5% vs 70.8%,
P = .032) and late revascularizations (35.4% vs 15.3%,
P = .011) within this risk group compared with nondiabetics. Survival free from major adverse cardiac events differed significantly across the 3 Duke risk groups for diabetics (
P = .002) but not for controls (
P = .07). Survival free from composite events differed significantly across the 3 Duke risk groups for both diabetics and nondiabetics (
P < .0001). Overall, diabetics had higher rates of major adverse cardiac events, composite events (
P = .011), and coronary angiography (
P < .001) than nondiabetics. The DTS is a strong predictor of survival free of composite events in both groups by multivariate analysis.
The DTS predicted survival free from MACE and composite events equally well in patients with and without diabetes. |
| doi_str_mv | 10.1016/j.ahj.2004.09.058 |
| format | Article |
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We studied 100 diabetics and 202 age- and sex-matched nondiabetic controls without known coronary artery disease risk stratified by DTS and followed for a median duration of 6.6 years. The association between DTS and primary, secondary outcomes, composite events, and rate of coronary angiography was tested.
Survival free from cardiac death, nonfatal myocardial infarction, congestive heart failure, or early and late revascularization was 89%, 54%, and 13%, respectively, in the low-, intermediate-, and high-risk categories of diabetic group (
P < .0001), and 91%, 57%, and 17%, respectively, in the low- to high-risk groups of nondiabetics (
P < .0001). During follow-up, diabetics had more secondary events (
P = .011) and coronary angiography (
P < .001) compared with nondiabetics. The DTS was a strong independent predictor of composite events in both diabetics (
P < .001) and nondiabetics (
P < .001). A significant number of diabetics were classified as intermediate risk and had a significantly higher incidence of coronary angiography (87.5% vs 70.8%,
P = .032) and late revascularizations (35.4% vs 15.3%,
P = .011) within this risk group compared with nondiabetics. Survival free from major adverse cardiac events differed significantly across the 3 Duke risk groups for diabetics (
P = .002) but not for controls (
P = .07). Survival free from composite events differed significantly across the 3 Duke risk groups for both diabetics and nondiabetics (
P < .0001). Overall, diabetics had higher rates of major adverse cardiac events, composite events (
P = .011), and coronary angiography (
P < .001) than nondiabetics. The DTS is a strong predictor of survival free of composite events in both groups by multivariate analysis.
The DTS predicted survival free from MACE and composite events equally well in patients with and without diabetes.]]></description><identifier>ISSN: 0002-8703</identifier><identifier>EISSN: 1097-6744</identifier><identifier>DOI: 10.1016/j.ahj.2004.09.058</identifier><identifier>PMID: 16169334</identifier><identifier>CODEN: AHJOA2</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Biological and medical sciences ; Cardiology ; Cardiology. Vascular system ; Cardiovascular disease ; Cardiovascular Diseases - diagnosis ; Cardiovascular Diseases - epidemiology ; Diabetes Complications - diagnosis ; Diabetes Complications - epidemiology ; Diabetes. Impaired glucose tolerance ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Exercise Test ; Female ; Follow-Up Studies ; Heart attacks ; Humans ; Male ; Medical sciences ; Middle Aged ; Older people ; Predictive Value of Tests ; Prognosis ; Prospective Studies ; Risk Assessment</subject><ispartof>The American heart journal, 2005-09, Vol.150 (3), p.516-521</ispartof><rights>2005 Mosby, Inc.</rights><rights>2005 INIST-CNRS</rights><rights>Copyright Elsevier Limited Sep 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c475t-75526fdedd6c70120413e15b446063a5a6fedd56d0d5eef6a4d0fa476df1e7823</citedby><cites>FETCH-LOGICAL-c475t-75526fdedd6c70120413e15b446063a5a6fedd56d0d5eef6a4d0fa476df1e7823</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1504621584?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,3549,27923,27924,45994,64384,64386,64388,72340</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17156905$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16169334$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lakkireddy, Dhanunjaya R.</creatorcontrib><creatorcontrib>Bhakkad, Jyothi</creatorcontrib><creatorcontrib>Korlakunta, Hema L.</creatorcontrib><creatorcontrib>Ryschon, Kay</creatorcontrib><creatorcontrib>Shen, Xuedong</creatorcontrib><creatorcontrib>Mooss, Aryan N.</creatorcontrib><creatorcontrib>Mohiuddin, Syed M.</creatorcontrib><title>Prognostic value of the Duke Treadmill Score in diabetic patients</title><title>The American heart journal</title><addtitle>Am Heart J</addtitle><description><![CDATA[The Duke Treadmill Score (DTS) is an established clinical tool for risk stratification of coronary artery disease. We sought to assess the prognostic value of the DTS in diabetics compared with nondiabetics in this study.
We studied 100 diabetics and 202 age- and sex-matched nondiabetic controls without known coronary artery disease risk stratified by DTS and followed for a median duration of 6.6 years. The association between DTS and primary, secondary outcomes, composite events, and rate of coronary angiography was tested.
Survival free from cardiac death, nonfatal myocardial infarction, congestive heart failure, or early and late revascularization was 89%, 54%, and 13%, respectively, in the low-, intermediate-, and high-risk categories of diabetic group (
P < .0001), and 91%, 57%, and 17%, respectively, in the low- to high-risk groups of nondiabetics (
P < .0001). During follow-up, diabetics had more secondary events (
P = .011) and coronary angiography (
P < .001) compared with nondiabetics. The DTS was a strong independent predictor of composite events in both diabetics (
P < .001) and nondiabetics (
P < .001). A significant number of diabetics were classified as intermediate risk and had a significantly higher incidence of coronary angiography (87.5% vs 70.8%,
P = .032) and late revascularizations (35.4% vs 15.3%,
P = .011) within this risk group compared with nondiabetics. Survival free from major adverse cardiac events differed significantly across the 3 Duke risk groups for diabetics (
P = .002) but not for controls (
P = .07). Survival free from composite events differed significantly across the 3 Duke risk groups for both diabetics and nondiabetics (
P < .0001). Overall, diabetics had higher rates of major adverse cardiac events, composite events (
P = .011), and coronary angiography (
P < .001) than nondiabetics. The DTS is a strong predictor of survival free of composite events in both groups by multivariate analysis.
The DTS predicted survival free from MACE and composite events equally well in patients with and without diabetes.]]></description><subject>Biological and medical sciences</subject><subject>Cardiology</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular Diseases - diagnosis</subject><subject>Cardiovascular Diseases - epidemiology</subject><subject>Diabetes Complications - diagnosis</subject><subject>Diabetes Complications - epidemiology</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Etiopathogenesis. Screening. Investigations. Target tissue resistance</subject><subject>Exercise Test</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Heart attacks</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Older people</subject><subject>Predictive Value of Tests</subject><subject>Prognosis</subject><subject>Prospective Studies</subject><subject>Risk Assessment</subject><issn>0002-8703</issn><issn>1097-6744</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp90M9rFDEUwPEgit1W_wAvMiDtbcaXmeRlBk-l_oSCgvUcssmLzTg7WZOZgv-9WXah4MFTCPm8R_gy9opDw4Hj27Ex92PTAogGhgZk_4RtOAyqRiXEU7YBgLbuFXRn7DznsVyx7fE5O-PIceg6sWHX31L8Oce8BFs9mGmlKvpquafq_fqLqrtExu3CNFXfbUxUhblywWzpoPdmCTQv-QV75s2U6eXpvGA_Pn64u_lc33799OXm-ra2QsmlVlK26B05h1YBb0HwjrjcCoGAnZEGfXmT6MBJIo9GOPBGKHSek-rb7oJdHffuU_y9Ul70LmRL02RmimvW2MsBRCsKfPMPHOOa5vI3zSUIbLnsD4oflU0x50Re71PYmfRHc9CHunrUpa4-1NUw6FK3zLw-bV63O3KPE6ecBVyegMnWTD6Z2Yb86BSXOIAs7t3RUQn2ECjpbEtMSy4ksot2MfznG38BhvGVvw</recordid><startdate>20050901</startdate><enddate>20050901</enddate><creator>Lakkireddy, Dhanunjaya R.</creator><creator>Bhakkad, Jyothi</creator><creator>Korlakunta, Hema L.</creator><creator>Ryschon, Kay</creator><creator>Shen, Xuedong</creator><creator>Mooss, Aryan N.</creator><creator>Mohiuddin, Syed M.</creator><general>Mosby, Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7RV</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20050901</creationdate><title>Prognostic value of the Duke Treadmill Score in diabetic patients</title><author>Lakkireddy, Dhanunjaya R. ; Bhakkad, Jyothi ; Korlakunta, Hema L. ; Ryschon, Kay ; Shen, Xuedong ; Mooss, Aryan N. ; Mohiuddin, Syed M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c475t-75526fdedd6c70120413e15b446063a5a6fedd56d0d5eef6a4d0fa476df1e7823</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Biological and medical sciences</topic><topic>Cardiology</topic><topic>Cardiology. Vascular system</topic><topic>Cardiovascular disease</topic><topic>Cardiovascular Diseases - diagnosis</topic><topic>Cardiovascular Diseases - epidemiology</topic><topic>Diabetes Complications - diagnosis</topic><topic>Diabetes Complications - epidemiology</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Etiopathogenesis. Screening. Investigations. Target tissue resistance</topic><topic>Exercise Test</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Heart attacks</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Older people</topic><topic>Predictive Value of Tests</topic><topic>Prognosis</topic><topic>Prospective Studies</topic><topic>Risk Assessment</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lakkireddy, Dhanunjaya R.</creatorcontrib><creatorcontrib>Bhakkad, Jyothi</creatorcontrib><creatorcontrib>Korlakunta, Hema L.</creatorcontrib><creatorcontrib>Ryschon, Kay</creatorcontrib><creatorcontrib>Shen, Xuedong</creatorcontrib><creatorcontrib>Mooss, Aryan N.</creatorcontrib><creatorcontrib>Mohiuddin, Syed M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Physical Education Index</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Healthcare Administration Database (Alumni)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>The American heart journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lakkireddy, Dhanunjaya R.</au><au>Bhakkad, Jyothi</au><au>Korlakunta, Hema L.</au><au>Ryschon, Kay</au><au>Shen, Xuedong</au><au>Mooss, Aryan N.</au><au>Mohiuddin, Syed M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic value of the Duke Treadmill Score in diabetic patients</atitle><jtitle>The American heart journal</jtitle><addtitle>Am Heart J</addtitle><date>2005-09-01</date><risdate>2005</risdate><volume>150</volume><issue>3</issue><spage>516</spage><epage>521</epage><pages>516-521</pages><issn>0002-8703</issn><eissn>1097-6744</eissn><coden>AHJOA2</coden><abstract><![CDATA[The Duke Treadmill Score (DTS) is an established clinical tool for risk stratification of coronary artery disease. We sought to assess the prognostic value of the DTS in diabetics compared with nondiabetics in this study.
We studied 100 diabetics and 202 age- and sex-matched nondiabetic controls without known coronary artery disease risk stratified by DTS and followed for a median duration of 6.6 years. The association between DTS and primary, secondary outcomes, composite events, and rate of coronary angiography was tested.
Survival free from cardiac death, nonfatal myocardial infarction, congestive heart failure, or early and late revascularization was 89%, 54%, and 13%, respectively, in the low-, intermediate-, and high-risk categories of diabetic group (
P < .0001), and 91%, 57%, and 17%, respectively, in the low- to high-risk groups of nondiabetics (
P < .0001). During follow-up, diabetics had more secondary events (
P = .011) and coronary angiography (
P < .001) compared with nondiabetics. The DTS was a strong independent predictor of composite events in both diabetics (
P < .001) and nondiabetics (
P < .001). A significant number of diabetics were classified as intermediate risk and had a significantly higher incidence of coronary angiography (87.5% vs 70.8%,
P = .032) and late revascularizations (35.4% vs 15.3%,
P = .011) within this risk group compared with nondiabetics. Survival free from major adverse cardiac events differed significantly across the 3 Duke risk groups for diabetics (
P = .002) but not for controls (
P = .07). Survival free from composite events differed significantly across the 3 Duke risk groups for both diabetics and nondiabetics (
P < .0001). Overall, diabetics had higher rates of major adverse cardiac events, composite events (
P = .011), and coronary angiography (
P < .001) than nondiabetics. The DTS is a strong predictor of survival free of composite events in both groups by multivariate analysis.
The DTS predicted survival free from MACE and composite events equally well in patients with and without diabetes.]]></abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>16169334</pmid><doi>10.1016/j.ahj.2004.09.058</doi><tpages>6</tpages></addata></record> |
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| ispartof | The American heart journal, 2005-09, Vol.150 (3), p.516-521 |
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| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE; ProQuest Central UK/Ireland |
| subjects | Biological and medical sciences Cardiology Cardiology. Vascular system Cardiovascular disease Cardiovascular Diseases - diagnosis Cardiovascular Diseases - epidemiology Diabetes Complications - diagnosis Diabetes Complications - epidemiology Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Exercise Test Female Follow-Up Studies Heart attacks Humans Male Medical sciences Middle Aged Older people Predictive Value of Tests Prognosis Prospective Studies Risk Assessment |
| title | Prognostic value of the Duke Treadmill Score in diabetic patients |
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