Functional SNPs in the distal promoter of the ST2 gene are associated with atopic dermatitis
Atopic dermatitis (AD) is a common inflammatory skin disease associated with the local infiltration of T helper type 2 (Th2) cells. The ST2 gene encodes both membrane-bound ST2L and soluble ST2 (sST2) proteins by alternative splicing. The orphan receptor ST2L is functionally indispensable for Th2 ce...
Gespeichert in:
| Veröffentlicht in: | Human molecular genetics 2005-10, Vol.14 (19), p.2919-2927 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2927 |
|---|---|
| container_issue | 19 |
| container_start_page | 2919 |
| container_title | Human molecular genetics |
| container_volume | 14 |
| creator | Shimizu, Makiko Matsuda, Akira Yanagisawa, Ken Hirota, Tomomitsu Akahoshi, Mitsuteru Inomata, Naoko Ebe, Kouji Tanaka, Keiko Sugiura, Hisashi Nakashima, Kazuko Tamari, Mayumi Takahashi, Naomi Obara, Kazuhiko Enomoto, Tadao Okayama, Yoshimichi Gao, Pei-Song Huang, Shau-Ku Tominaga, Shin-ichi Ikezawa, Zenro Shirakawa, Taro |
| description | Atopic dermatitis (AD) is a common inflammatory skin disease associated with the local infiltration of T helper type 2 (Th2) cells. The ST2 gene encodes both membrane-bound ST2L and soluble ST2 (sST2) proteins by alternative splicing. The orphan receptor ST2L is functionally indispensable for Th2 cells. We found a significant genetic association between AD and the −26999G/A single nucleotide polymorphism (SNP) (χ2-test, raw P-value=0.000007, odds ratio 1.86) in the distal promoter region of the ST2 gene (chromosome 2q12) in a study of 452 AD patients and 636 healthy controls. The −26999A allele common among AD patients positively regulates the transcriptional activity of the ST2 gene. In addition, having at least one −26999A allele correlated with high sST2 concentrations and high total IgE levels in the sera from AD patients. Thus, the −26999A allele is correlated with an increased risk for AD. We also found that the −26999G/A SNP predominantly affected the transcriptional activity of hematopoietic cells. Immunohistochemical staining of a skin biopsy specimen from an AD patient in the acute stage showed ST2 staining in the keratinocytes as well as in the infiltrating cells in the dermal layer. Our data show that functional SNPs in the ST2 distal promoter region regulate ST2 expression which induces preferential activation of the Th2 response. Our findings will contribute to the evaluation of one of the genetic risk factors for AD. |
| doi_str_mv | 10.1093/hmg/ddi323 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_68590089</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>68590089</sourcerecordid><originalsourceid>FETCH-LOGICAL-c447t-b924cab2dbd0c9a06b2e87e2270a6ea091c3a602a11cb1e94002784d5ef6e3b3</originalsourceid><addsrcrecordid>eNqF0c9rFTEQB_Agin1WL_4BEgQ9CGsnyW6SPdrWWqVUoe8gRQjZZLYvdX88kyzqf2_0PSx48TAEJh-GYb6EPGXwmkErjjbjzZH3QXBxj6xYLaHioMV9soJW1pVsQR6QRyndAjBZC_WQHDDJmOaCr8iXs2VyOcyTHejV5adEw0TzBqkPKZfWNs7jnDHSuf_TvlpzeoMTUhtLpTS7YDN6-j3kDbV53gZHPcbR5pBDekwe9HZI-GT_HpL12dv1yXl18fHd-5M3F5Wra5WrruW1sx33nQfXWpAdR62QcwVWooWWOWElcMuY6xi2NQBXuvYN9hJFJw7Jy93Ysu23BVM2Y0gOh8FOOC_JSN20ALr9L-RQKy6EKvD5P_B2XmK5UTGMca20lAW92iEX55Qi9mYbw2jjT8PA_A7GlGDMLpiCn-0nLt2I_o7ukyjgxR7Y5OzQRzu5kO6cYk3DtS6u2rkSEP74-2_jVyOVUI05_3xtLht1en16fGw-iF8Z_KTs</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>211287866</pqid></control><display><type>article</type><title>Functional SNPs in the distal promoter of the ST2 gene are associated with atopic dermatitis</title><source>MEDLINE</source><source>Oxford University Press Journals All Titles (1996-Current)</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Shimizu, Makiko ; Matsuda, Akira ; Yanagisawa, Ken ; Hirota, Tomomitsu ; Akahoshi, Mitsuteru ; Inomata, Naoko ; Ebe, Kouji ; Tanaka, Keiko ; Sugiura, Hisashi ; Nakashima, Kazuko ; Tamari, Mayumi ; Takahashi, Naomi ; Obara, Kazuhiko ; Enomoto, Tadao ; Okayama, Yoshimichi ; Gao, Pei-Song ; Huang, Shau-Ku ; Tominaga, Shin-ichi ; Ikezawa, Zenro ; Shirakawa, Taro</creator><creatorcontrib>Shimizu, Makiko ; Matsuda, Akira ; Yanagisawa, Ken ; Hirota, Tomomitsu ; Akahoshi, Mitsuteru ; Inomata, Naoko ; Ebe, Kouji ; Tanaka, Keiko ; Sugiura, Hisashi ; Nakashima, Kazuko ; Tamari, Mayumi ; Takahashi, Naomi ; Obara, Kazuhiko ; Enomoto, Tadao ; Okayama, Yoshimichi ; Gao, Pei-Song ; Huang, Shau-Ku ; Tominaga, Shin-ichi ; Ikezawa, Zenro ; Shirakawa, Taro</creatorcontrib><description>Atopic dermatitis (AD) is a common inflammatory skin disease associated with the local infiltration of T helper type 2 (Th2) cells. The ST2 gene encodes both membrane-bound ST2L and soluble ST2 (sST2) proteins by alternative splicing. The orphan receptor ST2L is functionally indispensable for Th2 cells. We found a significant genetic association between AD and the −26999G/A single nucleotide polymorphism (SNP) (χ2-test, raw P-value=0.000007, odds ratio 1.86) in the distal promoter region of the ST2 gene (chromosome 2q12) in a study of 452 AD patients and 636 healthy controls. The −26999A allele common among AD patients positively regulates the transcriptional activity of the ST2 gene. In addition, having at least one −26999A allele correlated with high sST2 concentrations and high total IgE levels in the sera from AD patients. Thus, the −26999A allele is correlated with an increased risk for AD. We also found that the −26999G/A SNP predominantly affected the transcriptional activity of hematopoietic cells. Immunohistochemical staining of a skin biopsy specimen from an AD patient in the acute stage showed ST2 staining in the keratinocytes as well as in the infiltrating cells in the dermal layer. Our data show that functional SNPs in the ST2 distal promoter region regulate ST2 expression which induces preferential activation of the Th2 response. Our findings will contribute to the evaluation of one of the genetic risk factors for AD.</description><identifier>ISSN: 0964-6906</identifier><identifier>EISSN: 1460-2083</identifier><identifier>DOI: 10.1093/hmg/ddi323</identifier><identifier>PMID: 16118232</identifier><identifier>CODEN: HNGEE5</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Alleles ; Allergic diseases ; Biological and medical sciences ; Case-Control Studies ; Dermatitis, Atopic - genetics ; Dermatitis, Atopic - immunology ; Fibroblasts - chemistry ; Fibroblasts - metabolism ; Fundamental and applied biological sciences. Psychology ; Genes, Reporter ; Genetics of eukaryotes. Biological and molecular evolution ; Haplotypes ; Hematopoietic Stem Cells - chemistry ; Hematopoietic Stem Cells - metabolism ; Humans ; Immunopathology ; Interleukin-1 Receptor-Like 1 Protein ; Keratinocytes - chemistry ; Keratinocytes - metabolism ; Mast Cells - chemistry ; Mast Cells - metabolism ; Medical sciences ; Membrane Proteins - analysis ; Membrane Proteins - genetics ; Membrane Proteins - metabolism ; Molecular and cellular biology ; Molecular genetics ; Polymorphism, Single Nucleotide ; Promoter Regions, Genetic - genetics ; Receptors, Cell Surface ; Skin allergic diseases. Stinging insect allergies ; Th2 Cells - immunology ; Transcription, Genetic ; Transcription. Transcription factor. Splicing. Rna processing</subject><ispartof>Human molecular genetics, 2005-10, Vol.14 (19), p.2919-2927</ispartof><rights>2005 INIST-CNRS</rights><rights>Copyright Oxford University Press(England) Oct 1, 2005</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c447t-b924cab2dbd0c9a06b2e87e2270a6ea091c3a602a11cb1e94002784d5ef6e3b3</citedby><cites>FETCH-LOGICAL-c447t-b924cab2dbd0c9a06b2e87e2270a6ea091c3a602a11cb1e94002784d5ef6e3b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17155288$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16118232$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shimizu, Makiko</creatorcontrib><creatorcontrib>Matsuda, Akira</creatorcontrib><creatorcontrib>Yanagisawa, Ken</creatorcontrib><creatorcontrib>Hirota, Tomomitsu</creatorcontrib><creatorcontrib>Akahoshi, Mitsuteru</creatorcontrib><creatorcontrib>Inomata, Naoko</creatorcontrib><creatorcontrib>Ebe, Kouji</creatorcontrib><creatorcontrib>Tanaka, Keiko</creatorcontrib><creatorcontrib>Sugiura, Hisashi</creatorcontrib><creatorcontrib>Nakashima, Kazuko</creatorcontrib><creatorcontrib>Tamari, Mayumi</creatorcontrib><creatorcontrib>Takahashi, Naomi</creatorcontrib><creatorcontrib>Obara, Kazuhiko</creatorcontrib><creatorcontrib>Enomoto, Tadao</creatorcontrib><creatorcontrib>Okayama, Yoshimichi</creatorcontrib><creatorcontrib>Gao, Pei-Song</creatorcontrib><creatorcontrib>Huang, Shau-Ku</creatorcontrib><creatorcontrib>Tominaga, Shin-ichi</creatorcontrib><creatorcontrib>Ikezawa, Zenro</creatorcontrib><creatorcontrib>Shirakawa, Taro</creatorcontrib><title>Functional SNPs in the distal promoter of the ST2 gene are associated with atopic dermatitis</title><title>Human molecular genetics</title><addtitle>Hum. Mol. Genet</addtitle><description>Atopic dermatitis (AD) is a common inflammatory skin disease associated with the local infiltration of T helper type 2 (Th2) cells. The ST2 gene encodes both membrane-bound ST2L and soluble ST2 (sST2) proteins by alternative splicing. The orphan receptor ST2L is functionally indispensable for Th2 cells. We found a significant genetic association between AD and the −26999G/A single nucleotide polymorphism (SNP) (χ2-test, raw P-value=0.000007, odds ratio 1.86) in the distal promoter region of the ST2 gene (chromosome 2q12) in a study of 452 AD patients and 636 healthy controls. The −26999A allele common among AD patients positively regulates the transcriptional activity of the ST2 gene. In addition, having at least one −26999A allele correlated with high sST2 concentrations and high total IgE levels in the sera from AD patients. Thus, the −26999A allele is correlated with an increased risk for AD. We also found that the −26999G/A SNP predominantly affected the transcriptional activity of hematopoietic cells. Immunohistochemical staining of a skin biopsy specimen from an AD patient in the acute stage showed ST2 staining in the keratinocytes as well as in the infiltrating cells in the dermal layer. Our data show that functional SNPs in the ST2 distal promoter region regulate ST2 expression which induces preferential activation of the Th2 response. Our findings will contribute to the evaluation of one of the genetic risk factors for AD.</description><subject>Alleles</subject><subject>Allergic diseases</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Dermatitis, Atopic - genetics</subject><subject>Dermatitis, Atopic - immunology</subject><subject>Fibroblasts - chemistry</subject><subject>Fibroblasts - metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genes, Reporter</subject><subject>Genetics of eukaryotes. Biological and molecular evolution</subject><subject>Haplotypes</subject><subject>Hematopoietic Stem Cells - chemistry</subject><subject>Hematopoietic Stem Cells - metabolism</subject><subject>Humans</subject><subject>Immunopathology</subject><subject>Interleukin-1 Receptor-Like 1 Protein</subject><subject>Keratinocytes - chemistry</subject><subject>Keratinocytes - metabolism</subject><subject>Mast Cells - chemistry</subject><subject>Mast Cells - metabolism</subject><subject>Medical sciences</subject><subject>Membrane Proteins - analysis</subject><subject>Membrane Proteins - genetics</subject><subject>Membrane Proteins - metabolism</subject><subject>Molecular and cellular biology</subject><subject>Molecular genetics</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Promoter Regions, Genetic - genetics</subject><subject>Receptors, Cell Surface</subject><subject>Skin allergic diseases. Stinging insect allergies</subject><subject>Th2 Cells - immunology</subject><subject>Transcription, Genetic</subject><subject>Transcription. Transcription factor. Splicing. Rna processing</subject><issn>0964-6906</issn><issn>1460-2083</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0c9rFTEQB_Agin1WL_4BEgQ9CGsnyW6SPdrWWqVUoe8gRQjZZLYvdX88kyzqf2_0PSx48TAEJh-GYb6EPGXwmkErjjbjzZH3QXBxj6xYLaHioMV9soJW1pVsQR6QRyndAjBZC_WQHDDJmOaCr8iXs2VyOcyTHejV5adEw0TzBqkPKZfWNs7jnDHSuf_TvlpzeoMTUhtLpTS7YDN6-j3kDbV53gZHPcbR5pBDekwe9HZI-GT_HpL12dv1yXl18fHd-5M3F5Wra5WrruW1sx33nQfXWpAdR62QcwVWooWWOWElcMuY6xi2NQBXuvYN9hJFJw7Jy93Ysu23BVM2Y0gOh8FOOC_JSN20ALr9L-RQKy6EKvD5P_B2XmK5UTGMca20lAW92iEX55Qi9mYbw2jjT8PA_A7GlGDMLpiCn-0nLt2I_o7ukyjgxR7Y5OzQRzu5kO6cYk3DtS6u2rkSEP74-2_jVyOVUI05_3xtLht1en16fGw-iF8Z_KTs</recordid><startdate>20051001</startdate><enddate>20051001</enddate><creator>Shimizu, Makiko</creator><creator>Matsuda, Akira</creator><creator>Yanagisawa, Ken</creator><creator>Hirota, Tomomitsu</creator><creator>Akahoshi, Mitsuteru</creator><creator>Inomata, Naoko</creator><creator>Ebe, Kouji</creator><creator>Tanaka, Keiko</creator><creator>Sugiura, Hisashi</creator><creator>Nakashima, Kazuko</creator><creator>Tamari, Mayumi</creator><creator>Takahashi, Naomi</creator><creator>Obara, Kazuhiko</creator><creator>Enomoto, Tadao</creator><creator>Okayama, Yoshimichi</creator><creator>Gao, Pei-Song</creator><creator>Huang, Shau-Ku</creator><creator>Tominaga, Shin-ichi</creator><creator>Ikezawa, Zenro</creator><creator>Shirakawa, Taro</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20051001</creationdate><title>Functional SNPs in the distal promoter of the ST2 gene are associated with atopic dermatitis</title><author>Shimizu, Makiko ; Matsuda, Akira ; Yanagisawa, Ken ; Hirota, Tomomitsu ; Akahoshi, Mitsuteru ; Inomata, Naoko ; Ebe, Kouji ; Tanaka, Keiko ; Sugiura, Hisashi ; Nakashima, Kazuko ; Tamari, Mayumi ; Takahashi, Naomi ; Obara, Kazuhiko ; Enomoto, Tadao ; Okayama, Yoshimichi ; Gao, Pei-Song ; Huang, Shau-Ku ; Tominaga, Shin-ichi ; Ikezawa, Zenro ; Shirakawa, Taro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c447t-b924cab2dbd0c9a06b2e87e2270a6ea091c3a602a11cb1e94002784d5ef6e3b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Alleles</topic><topic>Allergic diseases</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>Dermatitis, Atopic - genetics</topic><topic>Dermatitis, Atopic - immunology</topic><topic>Fibroblasts - chemistry</topic><topic>Fibroblasts - metabolism</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genes, Reporter</topic><topic>Genetics of eukaryotes. Biological and molecular evolution</topic><topic>Haplotypes</topic><topic>Hematopoietic Stem Cells - chemistry</topic><topic>Hematopoietic Stem Cells - metabolism</topic><topic>Humans</topic><topic>Immunopathology</topic><topic>Interleukin-1 Receptor-Like 1 Protein</topic><topic>Keratinocytes - chemistry</topic><topic>Keratinocytes - metabolism</topic><topic>Mast Cells - chemistry</topic><topic>Mast Cells - metabolism</topic><topic>Medical sciences</topic><topic>Membrane Proteins - analysis</topic><topic>Membrane Proteins - genetics</topic><topic>Membrane Proteins - metabolism</topic><topic>Molecular and cellular biology</topic><topic>Molecular genetics</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Promoter Regions, Genetic - genetics</topic><topic>Receptors, Cell Surface</topic><topic>Skin allergic diseases. Stinging insect allergies</topic><topic>Th2 Cells - immunology</topic><topic>Transcription, Genetic</topic><topic>Transcription. Transcription factor. Splicing. Rna processing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shimizu, Makiko</creatorcontrib><creatorcontrib>Matsuda, Akira</creatorcontrib><creatorcontrib>Yanagisawa, Ken</creatorcontrib><creatorcontrib>Hirota, Tomomitsu</creatorcontrib><creatorcontrib>Akahoshi, Mitsuteru</creatorcontrib><creatorcontrib>Inomata, Naoko</creatorcontrib><creatorcontrib>Ebe, Kouji</creatorcontrib><creatorcontrib>Tanaka, Keiko</creatorcontrib><creatorcontrib>Sugiura, Hisashi</creatorcontrib><creatorcontrib>Nakashima, Kazuko</creatorcontrib><creatorcontrib>Tamari, Mayumi</creatorcontrib><creatorcontrib>Takahashi, Naomi</creatorcontrib><creatorcontrib>Obara, Kazuhiko</creatorcontrib><creatorcontrib>Enomoto, Tadao</creatorcontrib><creatorcontrib>Okayama, Yoshimichi</creatorcontrib><creatorcontrib>Gao, Pei-Song</creatorcontrib><creatorcontrib>Huang, Shau-Ku</creatorcontrib><creatorcontrib>Tominaga, Shin-ichi</creatorcontrib><creatorcontrib>Ikezawa, Zenro</creatorcontrib><creatorcontrib>Shirakawa, Taro</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Human molecular genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shimizu, Makiko</au><au>Matsuda, Akira</au><au>Yanagisawa, Ken</au><au>Hirota, Tomomitsu</au><au>Akahoshi, Mitsuteru</au><au>Inomata, Naoko</au><au>Ebe, Kouji</au><au>Tanaka, Keiko</au><au>Sugiura, Hisashi</au><au>Nakashima, Kazuko</au><au>Tamari, Mayumi</au><au>Takahashi, Naomi</au><au>Obara, Kazuhiko</au><au>Enomoto, Tadao</au><au>Okayama, Yoshimichi</au><au>Gao, Pei-Song</au><au>Huang, Shau-Ku</au><au>Tominaga, Shin-ichi</au><au>Ikezawa, Zenro</au><au>Shirakawa, Taro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Functional SNPs in the distal promoter of the ST2 gene are associated with atopic dermatitis</atitle><jtitle>Human molecular genetics</jtitle><addtitle>Hum. Mol. Genet</addtitle><date>2005-10-01</date><risdate>2005</risdate><volume>14</volume><issue>19</issue><spage>2919</spage><epage>2927</epage><pages>2919-2927</pages><issn>0964-6906</issn><eissn>1460-2083</eissn><coden>HNGEE5</coden><abstract>Atopic dermatitis (AD) is a common inflammatory skin disease associated with the local infiltration of T helper type 2 (Th2) cells. The ST2 gene encodes both membrane-bound ST2L and soluble ST2 (sST2) proteins by alternative splicing. The orphan receptor ST2L is functionally indispensable for Th2 cells. We found a significant genetic association between AD and the −26999G/A single nucleotide polymorphism (SNP) (χ2-test, raw P-value=0.000007, odds ratio 1.86) in the distal promoter region of the ST2 gene (chromosome 2q12) in a study of 452 AD patients and 636 healthy controls. The −26999A allele common among AD patients positively regulates the transcriptional activity of the ST2 gene. In addition, having at least one −26999A allele correlated with high sST2 concentrations and high total IgE levels in the sera from AD patients. Thus, the −26999A allele is correlated with an increased risk for AD. We also found that the −26999G/A SNP predominantly affected the transcriptional activity of hematopoietic cells. Immunohistochemical staining of a skin biopsy specimen from an AD patient in the acute stage showed ST2 staining in the keratinocytes as well as in the infiltrating cells in the dermal layer. Our data show that functional SNPs in the ST2 distal promoter region regulate ST2 expression which induces preferential activation of the Th2 response. Our findings will contribute to the evaluation of one of the genetic risk factors for AD.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>16118232</pmid><doi>10.1093/hmg/ddi323</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0964-6906 |
| ispartof | Human molecular genetics, 2005-10, Vol.14 (19), p.2919-2927 |
| issn | 0964-6906 1460-2083 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68590089 |
| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals |
| subjects | Alleles Allergic diseases Biological and medical sciences Case-Control Studies Dermatitis, Atopic - genetics Dermatitis, Atopic - immunology Fibroblasts - chemistry Fibroblasts - metabolism Fundamental and applied biological sciences. Psychology Genes, Reporter Genetics of eukaryotes. Biological and molecular evolution Haplotypes Hematopoietic Stem Cells - chemistry Hematopoietic Stem Cells - metabolism Humans Immunopathology Interleukin-1 Receptor-Like 1 Protein Keratinocytes - chemistry Keratinocytes - metabolism Mast Cells - chemistry Mast Cells - metabolism Medical sciences Membrane Proteins - analysis Membrane Proteins - genetics Membrane Proteins - metabolism Molecular and cellular biology Molecular genetics Polymorphism, Single Nucleotide Promoter Regions, Genetic - genetics Receptors, Cell Surface Skin allergic diseases. Stinging insect allergies Th2 Cells - immunology Transcription, Genetic Transcription. Transcription factor. Splicing. Rna processing |
| title | Functional SNPs in the distal promoter of the ST2 gene are associated with atopic dermatitis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-14T01%3A49%3A42IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Functional%20SNPs%20in%20the%20distal%20promoter%20of%20the%20ST2%20gene%20are%20associated%20with%20atopic%20dermatitis&rft.jtitle=Human%20molecular%20genetics&rft.au=Shimizu,%20Makiko&rft.date=2005-10-01&rft.volume=14&rft.issue=19&rft.spage=2919&rft.epage=2927&rft.pages=2919-2927&rft.issn=0964-6906&rft.eissn=1460-2083&rft.coden=HNGEE5&rft_id=info:doi/10.1093/hmg/ddi323&rft_dat=%3Cproquest_cross%3E68590089%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=211287866&rft_id=info:pmid/16118232&rfr_iscdi=true |