WT1 induces apoptosis through transcriptional regulation of the proapoptotic Bcl-2 family member bak

Wilms' tumor or nephroblastoma is believed to arise from embryonic nephrogenic rests of multipotent cells that fail to terminally differentiate into epithelium and continue to proliferate. The WT1 tumor suppressor gene, a transcription factor controlling the mesenchymal-epithelial transition in...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2005-09, Vol.65 (18), p.8174-8182
Hauptverfasser:	MORRISON, Debra J, ENGLISH, Milton A, LICHT, Jonathan D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - genetics bcl-2 Homologous Antagonist-Killer Protein - antagonists & inhibitors bcl-2 Homologous Antagonist-Killer Protein - biosynthesis bcl-2 Homologous Antagonist-Killer Protein - genetics Biological and medical sciences Bone Neoplasms - genetics Bone Neoplasms - metabolism Bone Neoplasms - pathology Cell Growth Processes - genetics Cell Line, Tumor DNA, Neoplasm - biosynthesis Genes, Wilms Tumor Humans Kidneys Medical sciences Mice Mutation, Missense Nephrology. Urinary tract diseases Osteosarcoma - genetics Osteosarcoma - metabolism Osteosarcoma - pathology Promoter Regions, Genetic Transcriptional Activation Tumors of the urinary system Wilms Tumor - genetics Wilms Tumor - metabolism Wilms Tumor - pathology WT1 Proteins - biosynthesis WT1 Proteins - genetics WT1 Proteins - physiology
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