Suppression of mammary carcinoma growth by retinoic acid : Proapoptotic genes are targets for retinoic acid receptor and cellular retinoic acid-binding protein II signaling

Retinoic acid (RA) displays pronounced anticarcinogenic activities in several types of cancer. Whereas the mechanisms that underlie this activity remain incompletely understood, tumor suppression by RA is believed to emanate primarily from its ability to regulate transcription of multiple target gen...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2005-09, Vol.65 (18), p.8193-8199
Hauptverfasser:	DONATO, Leslie J, NOY, Noa
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Antineoplastic Agents - pharmacology Apoptosis - drug effects Apoptosis - genetics Apoptotic Protease-Activating Factor 1 Biological and medical sciences Breast Neoplasms - drug therapy Breast Neoplasms - genetics Breast Neoplasms - pathology Caspase 7 Caspase 9 Caspases - biosynthesis Caspases - genetics Cell Growth Processes - drug effects Cell Line, Tumor Chemotherapy Gynecology. Andrology. Obstetrics Humans Introns Mammary gland diseases Medical sciences Pharmacology. Drug treatments Proteins - genetics Proteins - metabolism Receptors, Retinoic Acid - physiology RNA, Messenger - biosynthesis RNA, Messenger - genetics Signal Transduction - drug effects Signal Transduction - physiology Tretinoin - pharmacology Tumors Up-Regulation - drug effects
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