A Dietary Supplement Improves Outcome in an Experimental Influenza Model in Old Mice
: Twenty‐month‐old Swiss mice were allocated into three groups: (A) control; (B) infected group; and (C) infected but treated with 5 mg of the phytocompound MMT. Mice were infected intranasally with 30 μL of 75 HA viral units. MMT markedly blunted the nasal signs of virus infection and the febrile...
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| Veröffentlicht in: | Annals of the New York Academy of Sciences 2006-05, Vol.1067 (1), p.414-419 |
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| container_title | Annals of the New York Academy of Sciences |
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| creator | CERVI, J. MAROTTA, F. BATER, C. MASULAIR, K. MINELLI, E. HARADA, M. MARANDOLA, P. |
| description | : Twenty‐month‐old Swiss mice were allocated into three groups: (A) control; (B) infected group; and (C) infected but treated with 5 mg of the phytocompound MMT. Mice were infected intranasally with 30 μL of 75 HA viral units. MMT markedly blunted the nasal signs of virus infection and the febrile response. Formazan‐positive cells, lung and plasma lipoperoxides, and TNF‐α in lung tissue increased during viral infection, but improvement was seen in the MMT‐treated group (P < 0.05). MMT also normalized SOD, catalase activities, and ascorbic acid and determined a significant decrease of lung but not nasal viral titer, although nasal inflammatory infiltrate dropped significantly. MMT has potential clinical applications with and has an excellent safety profile even in old animals. |
| doi_str_mv | 10.1196/annals.1354.059 |
| format | Article |
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Mice were infected intranasally with 30 μL of 75 HA viral units. MMT markedly blunted the nasal signs of virus infection and the febrile response. Formazan‐positive cells, lung and plasma lipoperoxides, and TNF‐α in lung tissue increased during viral infection, but improvement was seen in the MMT‐treated group (P < 0.05). MMT also normalized SOD, catalase activities, and ascorbic acid and determined a significant decrease of lung but not nasal viral titer, although nasal inflammatory infiltrate dropped significantly. 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MMT has potential clinical applications with and has an excellent safety profile even in old animals.</description><subject>Administration, Oral</subject><subject>Aging - metabolism</subject><subject>Animals</subject><subject>Antioxidants - administration & dosage</subject><subject>Ascorbic Acid - analysis</subject><subject>Bronchoalveolar Lavage Fluid - chemistry</subject><subject>Catalase - analysis</subject><subject>Chemokine CCL5 - analysis</subject><subject>Dietary Supplements</subject><subject>Disease Models, Animal</subject><subject>Drug Administration Schedule</subject><subject>influenza model</subject><subject>Lung - enzymology</subject><subject>Lung - metabolism</subject><subject>Lung - virology</subject><subject>Mice</subject><subject>old mice</subject><subject>Orthomyxoviridae Infections - diet therapy</subject><subject>Orthomyxoviridae Infections - virology</subject><subject>phytocompound</subject><subject>Random Allocation</subject><subject>RANTES</subject><subject>Superoxide Dismutase - analysis</subject><subject>TNF-alpha</subject><subject>Treatment Outcome</subject><subject>Tumor Necrosis Factor-alpha - analysis</subject><subject>Viral Load</subject><issn>0077-8923</issn><issn>1749-6632</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtv1DAUhS1ERYfCmh3yil2mdvxejvoYBrUdiZZWrCwnuZYCzqNxAi2_Hg8ZleWs7uY7n67OQegDJUtKjTx1betCXFIm-JII8wotqOImk5Llr9GCEKUybXJ2jN7G-IMQmmuu3qBjKjXhJCcLdLfC5zWMbnjGt1PfB2igHfGm6YfuF0S8ncayawDXLXYtvnjqYah3hAt40_owQfvH4euugrBDtqHC13UJ79CRT2_B-_09Qd8uL-7OPmdX2_XmbHWVlZwZk5W-0rz0pcwVY6rKDS80GM8r0FT53BciEawARUWlhXNCOE61Kig4r1wl2Qn6NHvTt48TxNE2dSwhBNdCN0UrtdBK0PwgyBiVRurDRmpSgUaRBJ7OYDl0MQ7gbZ-aSTVaSuxuGjtPY3fT2DRNSnzcq6eigeo_v98iAWwGftcBng_57M331e0_bTan6jjC00vKDT-tVEwJ-3Cztvdsrcz55Vf7hf0FQrmq6w</recordid><startdate>200605</startdate><enddate>200605</enddate><creator>CERVI, J.</creator><creator>MAROTTA, F.</creator><creator>BATER, C.</creator><creator>MASULAIR, K.</creator><creator>MINELLI, E.</creator><creator>HARADA, M.</creator><creator>MARANDOLA, P.</creator><general>Blackwell Publishing Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>7SP</scope><scope>7U5</scope><scope>8FD</scope><scope>L7M</scope><scope>7X8</scope></search><sort><creationdate>200605</creationdate><title>A Dietary Supplement Improves Outcome in an Experimental Influenza Model in Old Mice</title><author>CERVI, J. ; 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| subjects | Administration, Oral Aging - metabolism Animals Antioxidants - administration & dosage Ascorbic Acid - analysis Bronchoalveolar Lavage Fluid - chemistry Catalase - analysis Chemokine CCL5 - analysis Dietary Supplements Disease Models, Animal Drug Administration Schedule influenza model Lung - enzymology Lung - metabolism Lung - virology Mice old mice Orthomyxoviridae Infections - diet therapy Orthomyxoviridae Infections - virology phytocompound Random Allocation RANTES Superoxide Dismutase - analysis TNF-alpha Treatment Outcome Tumor Necrosis Factor-alpha - analysis Viral Load |
| title | A Dietary Supplement Improves Outcome in an Experimental Influenza Model in Old Mice |
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