Reduction of tissue plasminogen activator-induced matrix metalloproteinase-9 by simvastatin in astrocytes

Hemorrhagic conversion after tissue plasminogen activator (tPA) stroke therapy has been linked with elevations in matrix metalloproteinase-9 (MMP-9) at the neurovascular interface. Here, we test the idea that statins may directly ameliorate tPA-induced MMP-9 dysregulation. Recombinant human tPA (5 m...

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Veröffentlicht in:	Stroke (1970) 2006-07, Vol.37 (7), p.1910-1912
Hauptverfasser:	WANG, Sophia, LEE, Sun-Ryung, GUO, Shu-Zhen, WOO JEAN KIM, MONTANER, Joan, XIAOYING WANG, LO, Eng H
Format:	Artikel
Sprache:	eng
Schlagworte:	Amides - pharmacology Animals Astrocytes - drug effects Astrocytes - enzymology Biological and medical sciences Blood. Blood coagulation. Reticuloendothelial system Cells, Cultured - drug effects Cells, Cultured - enzymology Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges Cerebral Hemorrhage - etiology Drug Evaluation, Preclinical Enzyme Induction - drug effects Fundamental and applied biological sciences. Psychology Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology Intracellular Signaling Peptides and Proteins Matrix Metalloproteinase 2 - biosynthesis Matrix Metalloproteinase 2 - genetics Matrix Metalloproteinase 9 - biosynthesis Matrix Metalloproteinase 9 - genetics Medical sciences Neurology Neuroprotective Agents - pharmacology Pharmacology. Drug treatments Protein-Serine-Threonine Kinases - antagonists & inhibitors Pyridines - pharmacology Rats Recombinant Proteins - pharmacology rho-Associated Kinases Signal Transduction - drug effects Simvastatin - pharmacology Stroke - complications Stroke - enzymology Vascular diseases and vascular malformations of the nervous system Vertebrates: nervous system and sense organs
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