Impaired alveolization in mice deficient in membrane-type matrix metalloproteinase 1 (MT1-MMP)

To clarify the involvement of membrane-type matrix metalloproteinase 1 (MT1-MMP) in lung organogenesis, we studied the lung morphology of 13-day-old MT1-MMP null mice. The lung architecture in MT1-MMP null mice was abnormal, and the airspace compartments were characterized by smooth walls and larger...

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Veröffentlicht in:	Medical molecular morphology 2005-03, Vol.38 (1), p.43-46
Hauptverfasser:	Irie, Kazuharu, Komori, Kiyoshi, Seiki, Motoharu, Tsuruga, Eichi, Sakakura, Yasunori, Kaku, Tohru, Yajima, Toshihiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Down-Regulation Matrix Metalloproteinase 14 Matrix Metalloproteinase 2 - metabolism Matrix Metalloproteinases, Membrane-Associated Metalloendopeptidases - deficiency Metalloendopeptidases - genetics Mice Mice, Mutant Strains Organogenesis - genetics Pulmonary Alveoli - enzymology Pulmonary Alveoli - growth & development Pulmonary Alveoli - ultrastructure
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