Replacement of a Proline with Silaproline Causes a 20-Fold Increase in the Cellular Uptake of a Pro-Rich Peptide

The results presented here show that elementary design enhancements have led to a 20-fold increase in the cellular uptake properties of a Pro-rich cell-penetrating peptide. These results are relevant not only due to the increasing interest in using CPPs as molecular shuttles for intracellular drug d...

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Veröffentlicht in:	Journal of the American Chemical Society 2006-07, Vol.128 (26), p.8479-8483
Hauptverfasser:	Pujals, Sílvia, Fernández-Carneado, Jimena, Kogan, Marcelo J, Martinez, Jean, Cavelier, Florine, Giralt, Ernest
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Cell Survival - drug effects Circular Dichroism - methods Conformational dynamics in molecular biology Drug Carriers - chemical synthesis Drug Carriers - chemistry Drug Carriers - pharmacokinetics Fundamental and applied biological sciences. Psychology HeLa Cells Humans Microscopy, Electron, Transmission - methods Molecular biophysics Molecular Conformation Organosilicon Compounds - chemistry Organosilicon Compounds - metabolism Peptides - chemical synthesis Peptides - chemistry Peptides - pharmacokinetics Proline - analogs & derivatives Proline - chemistry Proline - metabolism Proline-Rich Protein Domains Protein Transport - drug effects Sensitivity and Specificity Structure-Activity Relationship
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