The antioxidant effect of beta-Glucan on oxidative stress status in experimental spinal cord injury in rats
This study was performed to investigate the antioxidant effect of beta-Glucan in experimental spinal cord injury (SCI). Injury was produced using weight-drop technique in rats. beta-Glucan was given by intraperitoneal injection following trauma. The rats were sacrificed at the sixth day of injury. O...
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| Veröffentlicht in: | Neurosurgical review 2005-10, Vol.28 (4), p.298-302 |
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| container_title | Neurosurgical review |
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| creator | Kayali, Hakan Ozdag, M Fatih Kahraman, Serdar Aydin, Ahmet Gonul, Engin Sayal, Ahmet Odabasi, Zeki Timurkaynak, Erdener |
| description | This study was performed to investigate the antioxidant effect of beta-Glucan in experimental spinal cord injury (SCI). Injury was produced using weight-drop technique in rats. beta-Glucan was given by intraperitoneal injection following trauma. The rats were sacrificed at the sixth day of injury. Oxidative stress status was assessed by measuring the spinal cord tissue content of Malonyldialdehyde (MDA), Superoxide Dismutase (SOD) and Gluthatione Peroxidase (GSH-Px) activities. No effect of beta-Glucan on SOD and MDA activities was found but, GSH-Px levels were found to decrease to the baseline (preinjury) levels when it was compared to untreated group (U=0.000; p=0.002). According to our results, beta-Glucan works like a scavenger and has an antioxidant effect on lipid peroxidation in spinal cord injury. |
| doi_str_mv | 10.1007/s10143-005-0389-2 |
| format | Article |
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Injury was produced using weight-drop technique in rats. beta-Glucan was given by intraperitoneal injection following trauma. The rats were sacrificed at the sixth day of injury. Oxidative stress status was assessed by measuring the spinal cord tissue content of Malonyldialdehyde (MDA), Superoxide Dismutase (SOD) and Gluthatione Peroxidase (GSH-Px) activities. No effect of beta-Glucan on SOD and MDA activities was found but, GSH-Px levels were found to decrease to the baseline (preinjury) levels when it was compared to untreated group (U=0.000; p=0.002). According to our results, beta-Glucan works like a scavenger and has an antioxidant effect on lipid peroxidation in spinal cord injury.</description><identifier>ISSN: 0344-5607</identifier><identifier>EISSN: 1437-2320</identifier><identifier>DOI: 10.1007/s10143-005-0389-2</identifier><identifier>PMID: 15864722</identifier><language>eng</language><publisher>Germany</publisher><subject>Animals ; Antioxidants - pharmacology ; beta-Glucans - pharmacology ; Free Radical Scavengers - pharmacology ; Glutathione Peroxidase - metabolism ; Injections, Intraperitoneal ; Lipid Peroxidation - drug effects ; Male ; Malondialdehyde - metabolism ; Oxidative Stress - drug effects ; Rats ; Rats, Sprague-Dawley ; Spinal Cord Injuries - metabolism ; Spinal Cord Injuries - pathology ; Superoxide Dismutase - metabolism</subject><ispartof>Neurosurgical review, 2005-10, Vol.28 (4), p.298-302</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c299t-d20e8156ba815027cec2b7022d19ed92cf4695c6fcab8985054abf00cd65ee883</citedby><cites>FETCH-LOGICAL-c299t-d20e8156ba815027cec2b7022d19ed92cf4695c6fcab8985054abf00cd65ee883</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15864722$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kayali, Hakan</creatorcontrib><creatorcontrib>Ozdag, M Fatih</creatorcontrib><creatorcontrib>Kahraman, Serdar</creatorcontrib><creatorcontrib>Aydin, Ahmet</creatorcontrib><creatorcontrib>Gonul, Engin</creatorcontrib><creatorcontrib>Sayal, Ahmet</creatorcontrib><creatorcontrib>Odabasi, Zeki</creatorcontrib><creatorcontrib>Timurkaynak, Erdener</creatorcontrib><title>The antioxidant effect of beta-Glucan on oxidative stress status in experimental spinal cord injury in rats</title><title>Neurosurgical review</title><addtitle>Neurosurg Rev</addtitle><description>This study was performed to investigate the antioxidant effect of beta-Glucan in experimental spinal cord injury (SCI). Injury was produced using weight-drop technique in rats. beta-Glucan was given by intraperitoneal injection following trauma. The rats were sacrificed at the sixth day of injury. Oxidative stress status was assessed by measuring the spinal cord tissue content of Malonyldialdehyde (MDA), Superoxide Dismutase (SOD) and Gluthatione Peroxidase (GSH-Px) activities. No effect of beta-Glucan on SOD and MDA activities was found but, GSH-Px levels were found to decrease to the baseline (preinjury) levels when it was compared to untreated group (U=0.000; p=0.002). According to our results, beta-Glucan works like a scavenger and has an antioxidant effect on lipid peroxidation in spinal cord injury.</description><subject>Animals</subject><subject>Antioxidants - pharmacology</subject><subject>beta-Glucans - pharmacology</subject><subject>Free Radical Scavengers - pharmacology</subject><subject>Glutathione Peroxidase - metabolism</subject><subject>Injections, Intraperitoneal</subject><subject>Lipid Peroxidation - drug effects</subject><subject>Male</subject><subject>Malondialdehyde - metabolism</subject><subject>Oxidative Stress - drug effects</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Spinal Cord Injuries - metabolism</subject><subject>Spinal Cord Injuries - pathology</subject><subject>Superoxide Dismutase - metabolism</subject><issn>0344-5607</issn><issn>1437-2320</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkNFLwzAQxoMobk7_AF8kT75FL2mTpo8ydAoDX-ZzSNMrdnbtTFKZ_70pGwjHfXD33Qf3I-SWwwMHKB4DB55nDEAyyHTJxBmZp0HBRCbgnMwhy3MmFRQzchXCFoAXJfBLMuNSq7wQYk6-Np9IbR_b4dDWSSk2DbpIh4ZWGC1bdaOzPR1STYbY_iAN0WMISWwcA217ioc9-naHfbQdDfu2T-IGX6fddvS_k8XbGK7JRWO7gDcnXZCPl-fN8pWt31dvy6c1c6IsI6sFoOZSVTZ1EIVDJ6oChKh5iXUpXJOrUjrVOFvpUkuQua0aAFcriah1tiD3x9y9H75HDNHs2uCw62yPwxiM0lLnIlfJyI9G54cQPDZmn96w_tdwMBNhcyRsEmEzETYi3dydwsdqh_X_xQlp9gfoSXhS</recordid><startdate>200510</startdate><enddate>200510</enddate><creator>Kayali, Hakan</creator><creator>Ozdag, M Fatih</creator><creator>Kahraman, Serdar</creator><creator>Aydin, Ahmet</creator><creator>Gonul, Engin</creator><creator>Sayal, Ahmet</creator><creator>Odabasi, Zeki</creator><creator>Timurkaynak, Erdener</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200510</creationdate><title>The antioxidant effect of beta-Glucan on oxidative stress status in experimental spinal cord injury in rats</title><author>Kayali, Hakan ; Ozdag, M Fatih ; Kahraman, Serdar ; Aydin, Ahmet ; Gonul, Engin ; Sayal, Ahmet ; Odabasi, Zeki ; Timurkaynak, Erdener</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c299t-d20e8156ba815027cec2b7022d19ed92cf4695c6fcab8985054abf00cd65ee883</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Animals</topic><topic>Antioxidants - pharmacology</topic><topic>beta-Glucans - pharmacology</topic><topic>Free Radical Scavengers - pharmacology</topic><topic>Glutathione Peroxidase - metabolism</topic><topic>Injections, Intraperitoneal</topic><topic>Lipid Peroxidation - drug effects</topic><topic>Male</topic><topic>Malondialdehyde - metabolism</topic><topic>Oxidative Stress - drug effects</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Spinal Cord Injuries - metabolism</topic><topic>Spinal Cord Injuries - pathology</topic><topic>Superoxide Dismutase - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kayali, Hakan</creatorcontrib><creatorcontrib>Ozdag, M Fatih</creatorcontrib><creatorcontrib>Kahraman, Serdar</creatorcontrib><creatorcontrib>Aydin, Ahmet</creatorcontrib><creatorcontrib>Gonul, Engin</creatorcontrib><creatorcontrib>Sayal, Ahmet</creatorcontrib><creatorcontrib>Odabasi, Zeki</creatorcontrib><creatorcontrib>Timurkaynak, Erdener</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neurosurgical review</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kayali, Hakan</au><au>Ozdag, M Fatih</au><au>Kahraman, Serdar</au><au>Aydin, Ahmet</au><au>Gonul, Engin</au><au>Sayal, Ahmet</au><au>Odabasi, Zeki</au><au>Timurkaynak, Erdener</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The antioxidant effect of beta-Glucan on oxidative stress status in experimental spinal cord injury in rats</atitle><jtitle>Neurosurgical review</jtitle><addtitle>Neurosurg Rev</addtitle><date>2005-10</date><risdate>2005</risdate><volume>28</volume><issue>4</issue><spage>298</spage><epage>302</epage><pages>298-302</pages><issn>0344-5607</issn><eissn>1437-2320</eissn><abstract>This study was performed to investigate the antioxidant effect of beta-Glucan in experimental spinal cord injury (SCI). Injury was produced using weight-drop technique in rats. beta-Glucan was given by intraperitoneal injection following trauma. The rats were sacrificed at the sixth day of injury. Oxidative stress status was assessed by measuring the spinal cord tissue content of Malonyldialdehyde (MDA), Superoxide Dismutase (SOD) and Gluthatione Peroxidase (GSH-Px) activities. No effect of beta-Glucan on SOD and MDA activities was found but, GSH-Px levels were found to decrease to the baseline (preinjury) levels when it was compared to untreated group (U=0.000; p=0.002). According to our results, beta-Glucan works like a scavenger and has an antioxidant effect on lipid peroxidation in spinal cord injury.</abstract><cop>Germany</cop><pmid>15864722</pmid><doi>10.1007/s10143-005-0389-2</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0344-5607 |
| ispartof | Neurosurgical review, 2005-10, Vol.28 (4), p.298-302 |
| issn | 0344-5607 1437-2320 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals (MCLS) |
| subjects | Animals Antioxidants - pharmacology beta-Glucans - pharmacology Free Radical Scavengers - pharmacology Glutathione Peroxidase - metabolism Injections, Intraperitoneal Lipid Peroxidation - drug effects Male Malondialdehyde - metabolism Oxidative Stress - drug effects Rats Rats, Sprague-Dawley Spinal Cord Injuries - metabolism Spinal Cord Injuries - pathology Superoxide Dismutase - metabolism |
| title | The antioxidant effect of beta-Glucan on oxidative stress status in experimental spinal cord injury in rats |
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