Small molecule regulation of Sir2 protein deacetylases

The Sir2 family of histone/protein deacetylases (sirtuins) is comprised of homologues found across all kingdoms of life. These enzymes catalyse a unique reaction in which NAD+ and acetylated substrate are converted into deacetylated product, nicotinamide, and a novel metabolite O‐acetyl ADP‐ribose....

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Veröffentlicht in:	The FEBS journal 2005-09, Vol.272 (18), p.4607-4616
Hauptverfasser:	Grubisha, Olivera, Smith, Brian C., Denu, John M.
Format:	Artikel
Sprache:	eng
Schlagworte:	deacetylation Enzyme Activation Enzyme Inhibitors NAD NAD - metabolism resveratrol Sir2 sirtinol sirtuin Sirtuins - agonists Sirtuins - antagonists & inhibitors Sirtuins - physiology splitomicin
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