Transcatheter closure of patent foramen ovale in older adults
Objectives: Comparing results of patent foramen ovale (PFO) closure in older and younger patient cohorts. Background: The literature pertaining to stroke and PFO has focused on patients 55years of age at the time of the procedure (mean 66.9 ± 8.3 years) and comprise the subject group (OLDER). The re...
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| Veröffentlicht in: | Catheterization and cardiovascular interventions 2006-07, Vol.68 (1), p.136-142 |
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| creator | Kiblawi, Fuad M. Sommer, Robert J. Levchuck, Sean G. |
| description | Objectives:
Comparing results of patent foramen ovale (PFO) closure in older and younger patient cohorts.
Background:
The literature pertaining to stroke and PFO has focused on patients 55years of age at the time of the procedure (mean 66.9 ± 8.3 years) and comprise the subject group (OLDER). The remaining 272 patients (mean 41.1 ± 7.7) comprise thecontrol group (YOUNGER). Data were collected prospectively in a registry type format.
Results:
Minor procedural complications were comparable: 7/184 (3.8%) OLDER vs. 12/272 (4.4%) YOUNGER (P = NS). In the follow‐up period (1–45 months, mean = 17.8 ± 11.1), there was no significant difference in the rate of recurrent stroke/TIA, headaches, or late unrelated death. Forty OLDER patients and 47 YOUNGER developed new onset atrial arrhythmia (P = NS). The incidence of new onset atrial fibrillation (AF), however, was significantly higher in OLDER (14/40 OLDER and only 2/47 YOUNGER, P < 0.025). All patients who were in normal sinus rhythm (NSR) before the procedure are in NSR at last follow‐up.
Conclusions:
Older patients should not be excluded from PFO closure. The procedure seems as safe and effective in preventing recurrent stroke in the older, as in the younger population. Older patients seem more prone to developing AF. © 2006 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/ccd.20722 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_68583242</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>68583242</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3612-129f79933d5c388f4196563a5ef84f2917b0d29ff08c90e273428cf2b61c1a203</originalsourceid><addsrcrecordid>eNp1kD1PwzAURS0EoqUw8AdQJiSGtP6InXhgQIG2iAJLUSsWy3VsEXCaYidA_z2BBJiY3h3OPXq6ABwjOEQQ4pFS2RDDGOMd0EcU4zDGbLnbZcQj1gMH3j9DCDnDfB_0EIsppRz1wfncybVXsnrSlXaBsqWvnQ5KE2xkpddVYEonC70OyjdpdZA3wWYNKLPaVv4Q7BlpvT7q7gA8jK_m6TSc3U-u04tZqAhDzQuYm5hzQjKqSJKYCHFGGZFUmyQymKN4BbOGMTBRHGockwgnyuAVQwpJDMkAnLbejStfa-0rUeReaWvlWpe1FyyhCcERbsCzFlSu9N5pIzYuL6TbCgTF11ai2Up8b9WwJ520XhU6-yO7cRpg1ALvudXb_00iTS9_lGHbyH2lP34b0r0IFpOYisXdRCxubyK2HE_FI_kEaK-AuA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>68583242</pqid></control><display><type>article</type><title>Transcatheter closure of patent foramen ovale in older adults</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Kiblawi, Fuad M. ; Sommer, Robert J. ; Levchuck, Sean G.</creator><creatorcontrib>Kiblawi, Fuad M. ; Sommer, Robert J. ; Levchuck, Sean G.</creatorcontrib><description>Objectives:
Comparing results of patent foramen ovale (PFO) closure in older and younger patient cohorts.
Background:
The literature pertaining to stroke and PFO has focused on patients <55 years of age.
Methods:
Between March 2000 and December 2003, 456 consecutive stroke/transient ischemic attack (TIA) patients (14.2–91.1 years, mean 51.4 ± 15.5) underwent successful closure of PFO with a CardioSEAL Septal Occluder by one operator at five hospitals. Of the 456 patients, 184 (40.4%) were >55years of age at the time of the procedure (mean 66.9 ± 8.3 years) and comprise the subject group (OLDER). The remaining 272 patients (mean 41.1 ± 7.7) comprise thecontrol group (YOUNGER). Data were collected prospectively in a registry type format.
Results:
Minor procedural complications were comparable: 7/184 (3.8%) OLDER vs. 12/272 (4.4%) YOUNGER (P = NS). In the follow‐up period (1–45 months, mean = 17.8 ± 11.1), there was no significant difference in the rate of recurrent stroke/TIA, headaches, or late unrelated death. Forty OLDER patients and 47 YOUNGER developed new onset atrial arrhythmia (P = NS). The incidence of new onset atrial fibrillation (AF), however, was significantly higher in OLDER (14/40 OLDER and only 2/47 YOUNGER, P < 0.025). All patients who were in normal sinus rhythm (NSR) before the procedure are in NSR at last follow‐up.
Conclusions:
Older patients should not be excluded from PFO closure. The procedure seems as safe and effective in preventing recurrent stroke in the older, as in the younger population. Older patients seem more prone to developing AF. © 2006 Wiley‐Liss, Inc.</description><identifier>ISSN: 1522-1946</identifier><identifier>EISSN: 1522-726X</identifier><identifier>DOI: 10.1002/ccd.20722</identifier><identifier>PMID: 16755591</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adolescent ; Adult ; Age Factors ; Aged ; Aged, 80 and over ; atrial fibrillation ; Atrial Fibrillation - complications ; Atrial Fibrillation - etiology ; Cardiac Catheterization - adverse effects ; Headache - etiology ; Heart Septal Defects, Atrial - complications ; Heart Septal Defects, Atrial - therapy ; Humans ; Middle Aged ; patent foramen ovale (PPO) ; Prospective Studies ; Recurrence ; Registries ; Research Design ; stroke ; Stroke - etiology ; Stroke - prevention & control ; transcatheter ; Treatment Outcome</subject><ispartof>Catheterization and cardiovascular interventions, 2006-07, Vol.68 (1), p.136-142</ispartof><rights>Copyright © 2006 Wiley‐Liss, Inc.</rights><rights>Copyright 2006 Wiley-Liss, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3612-129f79933d5c388f4196563a5ef84f2917b0d29ff08c90e273428cf2b61c1a203</citedby><cites>FETCH-LOGICAL-c3612-129f79933d5c388f4196563a5ef84f2917b0d29ff08c90e273428cf2b61c1a203</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fccd.20722$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fccd.20722$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16755591$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kiblawi, Fuad M.</creatorcontrib><creatorcontrib>Sommer, Robert J.</creatorcontrib><creatorcontrib>Levchuck, Sean G.</creatorcontrib><title>Transcatheter closure of patent foramen ovale in older adults</title><title>Catheterization and cardiovascular interventions</title><addtitle>Cathet. Cardiovasc. Intervent</addtitle><description>Objectives:
Comparing results of patent foramen ovale (PFO) closure in older and younger patient cohorts.
Background:
The literature pertaining to stroke and PFO has focused on patients <55 years of age.
Methods:
Between March 2000 and December 2003, 456 consecutive stroke/transient ischemic attack (TIA) patients (14.2–91.1 years, mean 51.4 ± 15.5) underwent successful closure of PFO with a CardioSEAL Septal Occluder by one operator at five hospitals. Of the 456 patients, 184 (40.4%) were >55years of age at the time of the procedure (mean 66.9 ± 8.3 years) and comprise the subject group (OLDER). The remaining 272 patients (mean 41.1 ± 7.7) comprise thecontrol group (YOUNGER). Data were collected prospectively in a registry type format.
Results:
Minor procedural complications were comparable: 7/184 (3.8%) OLDER vs. 12/272 (4.4%) YOUNGER (P = NS). In the follow‐up period (1–45 months, mean = 17.8 ± 11.1), there was no significant difference in the rate of recurrent stroke/TIA, headaches, or late unrelated death. Forty OLDER patients and 47 YOUNGER developed new onset atrial arrhythmia (P = NS). The incidence of new onset atrial fibrillation (AF), however, was significantly higher in OLDER (14/40 OLDER and only 2/47 YOUNGER, P < 0.025). All patients who were in normal sinus rhythm (NSR) before the procedure are in NSR at last follow‐up.
Conclusions:
Older patients should not be excluded from PFO closure. The procedure seems as safe and effective in preventing recurrent stroke in the older, as in the younger population. Older patients seem more prone to developing AF. © 2006 Wiley‐Liss, Inc.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>atrial fibrillation</subject><subject>Atrial Fibrillation - complications</subject><subject>Atrial Fibrillation - etiology</subject><subject>Cardiac Catheterization - adverse effects</subject><subject>Headache - etiology</subject><subject>Heart Septal Defects, Atrial - complications</subject><subject>Heart Septal Defects, Atrial - therapy</subject><subject>Humans</subject><subject>Middle Aged</subject><subject>patent foramen ovale (PPO)</subject><subject>Prospective Studies</subject><subject>Recurrence</subject><subject>Registries</subject><subject>Research Design</subject><subject>stroke</subject><subject>Stroke - etiology</subject><subject>Stroke - prevention & control</subject><subject>transcatheter</subject><subject>Treatment Outcome</subject><issn>1522-1946</issn><issn>1522-726X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kD1PwzAURS0EoqUw8AdQJiSGtP6InXhgQIG2iAJLUSsWy3VsEXCaYidA_z2BBJiY3h3OPXq6ABwjOEQQ4pFS2RDDGOMd0EcU4zDGbLnbZcQj1gMH3j9DCDnDfB_0EIsppRz1wfncybVXsnrSlXaBsqWvnQ5KE2xkpddVYEonC70OyjdpdZA3wWYNKLPaVv4Q7BlpvT7q7gA8jK_m6TSc3U-u04tZqAhDzQuYm5hzQjKqSJKYCHFGGZFUmyQymKN4BbOGMTBRHGockwgnyuAVQwpJDMkAnLbejStfa-0rUeReaWvlWpe1FyyhCcERbsCzFlSu9N5pIzYuL6TbCgTF11ai2Up8b9WwJ520XhU6-yO7cRpg1ALvudXb_00iTS9_lGHbyH2lP34b0r0IFpOYisXdRCxubyK2HE_FI_kEaK-AuA</recordid><startdate>200607</startdate><enddate>200607</enddate><creator>Kiblawi, Fuad M.</creator><creator>Sommer, Robert J.</creator><creator>Levchuck, Sean G.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200607</creationdate><title>Transcatheter closure of patent foramen ovale in older adults</title><author>Kiblawi, Fuad M. ; Sommer, Robert J. ; Levchuck, Sean G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3612-129f79933d5c388f4196563a5ef84f2917b0d29ff08c90e273428cf2b61c1a203</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>atrial fibrillation</topic><topic>Atrial Fibrillation - complications</topic><topic>Atrial Fibrillation - etiology</topic><topic>Cardiac Catheterization - adverse effects</topic><topic>Headache - etiology</topic><topic>Heart Septal Defects, Atrial - complications</topic><topic>Heart Septal Defects, Atrial - therapy</topic><topic>Humans</topic><topic>Middle Aged</topic><topic>patent foramen ovale (PPO)</topic><topic>Prospective Studies</topic><topic>Recurrence</topic><topic>Registries</topic><topic>Research Design</topic><topic>stroke</topic><topic>Stroke - etiology</topic><topic>Stroke - prevention & control</topic><topic>transcatheter</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kiblawi, Fuad M.</creatorcontrib><creatorcontrib>Sommer, Robert J.</creatorcontrib><creatorcontrib>Levchuck, Sean G.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Catheterization and cardiovascular interventions</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kiblawi, Fuad M.</au><au>Sommer, Robert J.</au><au>Levchuck, Sean G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transcatheter closure of patent foramen ovale in older adults</atitle><jtitle>Catheterization and cardiovascular interventions</jtitle><addtitle>Cathet. Cardiovasc. Intervent</addtitle><date>2006-07</date><risdate>2006</risdate><volume>68</volume><issue>1</issue><spage>136</spage><epage>142</epage><pages>136-142</pages><issn>1522-1946</issn><eissn>1522-726X</eissn><abstract>Objectives:
Comparing results of patent foramen ovale (PFO) closure in older and younger patient cohorts.
Background:
The literature pertaining to stroke and PFO has focused on patients <55 years of age.
Methods:
Between March 2000 and December 2003, 456 consecutive stroke/transient ischemic attack (TIA) patients (14.2–91.1 years, mean 51.4 ± 15.5) underwent successful closure of PFO with a CardioSEAL Septal Occluder by one operator at five hospitals. Of the 456 patients, 184 (40.4%) were >55years of age at the time of the procedure (mean 66.9 ± 8.3 years) and comprise the subject group (OLDER). The remaining 272 patients (mean 41.1 ± 7.7) comprise thecontrol group (YOUNGER). Data were collected prospectively in a registry type format.
Results:
Minor procedural complications were comparable: 7/184 (3.8%) OLDER vs. 12/272 (4.4%) YOUNGER (P = NS). In the follow‐up period (1–45 months, mean = 17.8 ± 11.1), there was no significant difference in the rate of recurrent stroke/TIA, headaches, or late unrelated death. Forty OLDER patients and 47 YOUNGER developed new onset atrial arrhythmia (P = NS). The incidence of new onset atrial fibrillation (AF), however, was significantly higher in OLDER (14/40 OLDER and only 2/47 YOUNGER, P < 0.025). All patients who were in normal sinus rhythm (NSR) before the procedure are in NSR at last follow‐up.
Conclusions:
Older patients should not be excluded from PFO closure. The procedure seems as safe and effective in preventing recurrent stroke in the older, as in the younger population. Older patients seem more prone to developing AF. © 2006 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>16755591</pmid><doi>10.1002/ccd.20722</doi><tpages>7</tpages></addata></record> |
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| subjects | Adolescent Adult Age Factors Aged Aged, 80 and over atrial fibrillation Atrial Fibrillation - complications Atrial Fibrillation - etiology Cardiac Catheterization - adverse effects Headache - etiology Heart Septal Defects, Atrial - complications Heart Septal Defects, Atrial - therapy Humans Middle Aged patent foramen ovale (PPO) Prospective Studies Recurrence Registries Research Design stroke Stroke - etiology Stroke - prevention & control transcatheter Treatment Outcome |
| title | Transcatheter closure of patent foramen ovale in older adults |
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