Humoral Immunity to Vimentin Is Associated with Cardiac Allograft Injury in Nonhuman Primates

Immunity to autologous protein has not previously been described following nonhuman primate cardiac transplant. Native hearts and cardiac allografts from cynomolgus monkeys were assessed by immunohistology for vimentin, a highly conserved intermediate filament protein. IgM and IgG to vimentin were m...

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Veröffentlicht in:	American journal of transplantation 2005-10, Vol.5 (10), p.2349-2359
Hauptverfasser:	Azimzadeh, Agnes M., Pfeiffer, Steffen, Wu, Guosheng S., Schröder, Carsten, Zhou, Hui, Zorn, George L., Kehry, Marilyn, Miller, Geraldine G., Rose, Marlene L., Pierson, Richard N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Allotransplantation Animals Antibody Formation autoantigen Biological and medical sciences Blotting, Western CD40 Ligand - biosynthesis Cell Nucleus - metabolism Complement Activation Complement C4b - immunology costimulation Cyclosporine - pharmacology Cytoplasm - metabolism Graft Rejection Graft Survival Heart Transplantation - methods heart‐primate Humans Immunoglobulin G - chemistry Immunoglobulin M - chemistry Immunohistochemistry Immunosuppressive Agents - pharmacology Influenza Vaccines - pharmacology Isoantibodies - chemistry Macaca fascicularis Medical sciences Myocardium - metabolism Myocardium - pathology Peptide Fragments - immunology Primates Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Time Factors Transplantation, Homologous - methods Vimentin Vimentin - chemistry Vimentin - immunology Vimentin - pharmacology
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