The 5alpha-reductase type II A49T and V89L high-activity allelic variants are more common in men with prostate cancer compared with the general population

To compare men with prostate disease with those from the general population regarding polymorphisms in the androgen receptor gene and in the 5alpha-reductase II (SRD5A2) gene. The SRD5A2 polymorphisms A49T, V89L and R227Q, the androgen receptor CAG and GGN repeats and sex hormone status was investig...

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Veröffentlicht in:	European urology 2005-10, Vol.48 (4), p.679-685
Hauptverfasser:	Giwercman, Yvonne L, Abrahamsson, Per-Anders, Giwercman, Aleksander, Gadaleanu, Virgil, Ahlgren, Göran
Format:	Artikel
Sprache:	eng
Schlagworte:	3-Oxo-5-alpha-Steroid 4-Dehydrogenase - blood 3-Oxo-5-alpha-Steroid 4-Dehydrogenase - genetics Aged Alanine Alleles Arginine Biomarkers, Tumor - blood Case-Control Studies Dihydrotestosterone - blood Disease Progression Follow-Up Studies Genetic Predisposition to Disease Genotype Glutamine Humans Leucine Luteinizing Hormone - blood Male Middle Aged Point Mutation Polymorphism, Genetic Prostatic Hyperplasia - blood Prostatic Hyperplasia - epidemiology Prostatic Hyperplasia - genetics Prostatic Neoplasms - blood Prostatic Neoplasms - epidemiology Prostatic Neoplasms - genetics Receptors, Androgen - blood Receptors, Androgen - genetics Risk Factors Sex Hormone-Binding Globulin - metabolism Sweden - epidemiology Terminal Repeat Sequences Testosterone - blood Threonine Valine
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