Neonatal screening for sickle cell disorders in Ouagadougou, Burkina Faso: a pilot study
Objectives: To determine the incidence of sickle cell disorders (SCDs) and the feasibility of a neonatal screening programme in Ouagadougou. Methods: During 2000, 2003 and 2004, 2341 cord blood samples obtained in five maternity hospitals in Ouagadougou were screened for SCDs using an isoelectric fo...
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| Veröffentlicht in: | Journal of medical screening 2005-01, Vol.12 (3), p.112-114 |
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| creator | Kafando, Eléonore Sawadogo, Mamadou Cotton, Frédéric Vertongen, Fanchon Gulbis, Béatrice |
| description | Objectives: To determine the incidence of sickle cell disorders (SCDs) and the feasibility of a neonatal screening programme in Ouagadougou.
Methods: During 2000, 2003 and 2004, 2341 cord blood samples obtained in five maternity hospitals in Ouagadougou were screened for SCDs using an isoelectric focusing technique. The feasibility of a neonatal screening programme was evaluated.
Results: The incidence of SCD was 1:57; 14 neonates were homozygous for haemoglobin (Hb)S and 27 were compound heterozygotes for HbSC. Thirty-two neonates were homozygous for HbC. The incidence of the HbC trait was 1:6; incidence of the HbS trait was 1:14. A centralized laboratory for neonatal screening of SCDs was established.
Conclusions: SCDs should be considered a major public health problem in Ouagadougou. A neonatal screening programme should be implemented, but to be effective it requires strategies adapted to the local situation. |
| doi_str_mv | 10.1258/0969141054855300 |
| format | Article |
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Methods: During 2000, 2003 and 2004, 2341 cord blood samples obtained in five maternity hospitals in Ouagadougou were screened for SCDs using an isoelectric focusing technique. The feasibility of a neonatal screening programme was evaluated.
Results: The incidence of SCD was 1:57; 14 neonates were homozygous for haemoglobin (Hb)S and 27 were compound heterozygotes for HbSC. Thirty-two neonates were homozygous for HbC. The incidence of the HbC trait was 1:6; incidence of the HbS trait was 1:14. A centralized laboratory for neonatal screening of SCDs was established.
Conclusions: SCDs should be considered a major public health problem in Ouagadougou. A neonatal screening programme should be implemented, but to be effective it requires strategies adapted to the local situation.</description><identifier>ISSN: 0969-1413</identifier><identifier>EISSN: 1475-5793</identifier><identifier>DOI: 10.1258/0969141054855300</identifier><identifier>PMID: 16156939</identifier><identifier>CODEN: JMSCFE</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>alpha-Thalassemia - diagnosis ; alpha-Thalassemia - genetics ; Anemia, Sickle Cell - diagnosis ; Anemia, Sickle Cell - genetics ; Burkina Faso ; Hemoglobin, Sickle - genetics ; Hemoglobins - chemistry ; Heterozygote ; Homozygote ; Humans ; Infant, Newborn ; Isoelectric Focusing ; Mass Screening ; Neonatal Screening - methods ; Phenotype ; Pilot Projects</subject><ispartof>Journal of medical screening, 2005-01, Vol.12 (3), p.112-114</ispartof><rights>2005 Royal Society of Medicine Press</rights><rights>Copyright Royal Society of Medicine Press Ltd. 2005</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c404t-f2e919e7e7b9c4489a1a73a70bebf27d0c1f9c725113b0d1e7ee58abae5a6a9e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16156939$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kafando, Eléonore</creatorcontrib><creatorcontrib>Sawadogo, Mamadou</creatorcontrib><creatorcontrib>Cotton, Frédéric</creatorcontrib><creatorcontrib>Vertongen, Fanchon</creatorcontrib><creatorcontrib>Gulbis, Béatrice</creatorcontrib><title>Neonatal screening for sickle cell disorders in Ouagadougou, Burkina Faso: a pilot study</title><title>Journal of medical screening</title><addtitle>J Med Screen</addtitle><description>Objectives: To determine the incidence of sickle cell disorders (SCDs) and the feasibility of a neonatal screening programme in Ouagadougou.
Methods: During 2000, 2003 and 2004, 2341 cord blood samples obtained in five maternity hospitals in Ouagadougou were screened for SCDs using an isoelectric focusing technique. The feasibility of a neonatal screening programme was evaluated.
Results: The incidence of SCD was 1:57; 14 neonates were homozygous for haemoglobin (Hb)S and 27 were compound heterozygotes for HbSC. Thirty-two neonates were homozygous for HbC. The incidence of the HbC trait was 1:6; incidence of the HbS trait was 1:14. A centralized laboratory for neonatal screening of SCDs was established.
Conclusions: SCDs should be considered a major public health problem in Ouagadougou. A neonatal screening programme should be implemented, but to be effective it requires strategies adapted to the local situation.</description><subject>alpha-Thalassemia - diagnosis</subject><subject>alpha-Thalassemia - genetics</subject><subject>Anemia, Sickle Cell - diagnosis</subject><subject>Anemia, Sickle Cell - genetics</subject><subject>Burkina Faso</subject><subject>Hemoglobin, Sickle - genetics</subject><subject>Hemoglobins - chemistry</subject><subject>Heterozygote</subject><subject>Homozygote</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Isoelectric Focusing</subject><subject>Mass Screening</subject><subject>Neonatal Screening - methods</subject><subject>Phenotype</subject><subject>Pilot Projects</subject><issn>0969-1413</issn><issn>1475-5793</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kEFLw0AQhRdRbK3ePcniwZPRnWw2yXrTYlUo9qLgLUySSUmbZutu9tB_b0oLhYKnObzvvTc8xq5BPECo0kehYw0RCBWlSkkhTtgQokQFKtHylA23ctDrcsAunFsIISRAes4GEIOKtdRD9vNJpsUOG-4KS9TW7ZxXxnJXF8uGeEFNw8vaGVuSdbxu-czjHEvj58bf8xdvl3WLfILOPHHk67oxHXedLzeX7KzCxtHV_o7Y9-T1a_weTGdvH-PnaVBEIuqCKiQNmhJKcl1EUaoRMJGYiJzyKkxKUUCliyRUADIXJfQkqRRzJIUxapIjdrfLXVvz68l12ap227exJeNdFqcqBSV0D94egQvjbdv_loXQF8tIiR4SO6iwxjlLVba29QrtJgORbSfPjifvLTf7XJ-vqDwY9hv3QLADHM7pUPpv4B9uEIiJ</recordid><startdate>20050101</startdate><enddate>20050101</enddate><creator>Kafando, Eléonore</creator><creator>Sawadogo, Mamadou</creator><creator>Cotton, Frédéric</creator><creator>Vertongen, Fanchon</creator><creator>Gulbis, Béatrice</creator><general>SAGE Publications</general><general>Sage Publications Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20050101</creationdate><title>Neonatal screening for sickle cell disorders in Ouagadougou, Burkina Faso: a pilot study</title><author>Kafando, Eléonore ; Sawadogo, Mamadou ; Cotton, Frédéric ; Vertongen, Fanchon ; Gulbis, Béatrice</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c404t-f2e919e7e7b9c4489a1a73a70bebf27d0c1f9c725113b0d1e7ee58abae5a6a9e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>alpha-Thalassemia - diagnosis</topic><topic>alpha-Thalassemia - genetics</topic><topic>Anemia, Sickle Cell - diagnosis</topic><topic>Anemia, Sickle Cell - genetics</topic><topic>Burkina Faso</topic><topic>Hemoglobin, Sickle - genetics</topic><topic>Hemoglobins - chemistry</topic><topic>Heterozygote</topic><topic>Homozygote</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Isoelectric Focusing</topic><topic>Mass Screening</topic><topic>Neonatal Screening - methods</topic><topic>Phenotype</topic><topic>Pilot Projects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kafando, Eléonore</creatorcontrib><creatorcontrib>Sawadogo, Mamadou</creatorcontrib><creatorcontrib>Cotton, Frédéric</creatorcontrib><creatorcontrib>Vertongen, Fanchon</creatorcontrib><creatorcontrib>Gulbis, Béatrice</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of medical screening</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kafando, Eléonore</au><au>Sawadogo, Mamadou</au><au>Cotton, Frédéric</au><au>Vertongen, Fanchon</au><au>Gulbis, Béatrice</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neonatal screening for sickle cell disorders in Ouagadougou, Burkina Faso: a pilot study</atitle><jtitle>Journal of medical screening</jtitle><addtitle>J Med Screen</addtitle><date>2005-01-01</date><risdate>2005</risdate><volume>12</volume><issue>3</issue><spage>112</spage><epage>114</epage><pages>112-114</pages><issn>0969-1413</issn><eissn>1475-5793</eissn><coden>JMSCFE</coden><abstract>Objectives: To determine the incidence of sickle cell disorders (SCDs) and the feasibility of a neonatal screening programme in Ouagadougou.
Methods: During 2000, 2003 and 2004, 2341 cord blood samples obtained in five maternity hospitals in Ouagadougou were screened for SCDs using an isoelectric focusing technique. The feasibility of a neonatal screening programme was evaluated.
Results: The incidence of SCD was 1:57; 14 neonates were homozygous for haemoglobin (Hb)S and 27 were compound heterozygotes for HbSC. Thirty-two neonates were homozygous for HbC. The incidence of the HbC trait was 1:6; incidence of the HbS trait was 1:14. A centralized laboratory for neonatal screening of SCDs was established.
Conclusions: SCDs should be considered a major public health problem in Ouagadougou. A neonatal screening programme should be implemented, but to be effective it requires strategies adapted to the local situation.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>16156939</pmid><doi>10.1258/0969141054855300</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | alpha-Thalassemia - diagnosis alpha-Thalassemia - genetics Anemia, Sickle Cell - diagnosis Anemia, Sickle Cell - genetics Burkina Faso Hemoglobin, Sickle - genetics Hemoglobins - chemistry Heterozygote Homozygote Humans Infant, Newborn Isoelectric Focusing Mass Screening Neonatal Screening - methods Phenotype Pilot Projects |
| title | Neonatal screening for sickle cell disorders in Ouagadougou, Burkina Faso: a pilot study |
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