Two New Benzoquinone Derivatives and Two New Bisorbicillinoids were Isolated from a Marine-derived Fungus Penicillium terrestre

Four new compounds were isolated from a marine-derived fungus Penicillium terrestre , namely 2-(2′, 3′-dihydrosorbyl)-3,6-dimethyl-5-hydroxy-1,4-benzoquinone ( 1 ), 3-acetonyl-2,6-dimethyl-5-hydroxy-1,4-benzoquinone ( 2 ), dihydrobisvertinolone ( 3 ), tetrahydrobisvertinolone ( 4 ). Their structures were established on the basis of spectroscopic methods. The absolute configurations of 3 and 4 were determined by their CD spectra. Their cytotoxic effects on P388 and A-549 cell lines were preliminarily examined by the MTT method.