Amadori adducts activate nuclear factor-kappaB-related proinflammatory genes in cultured human peritoneal mesothelial cells

Diabetes mellitus leads to a high incidence of several so-called complications, sharing similar pathophysiological features in several territories. Previous reports points at early nonenzymatic glycosylation products (Amadori adducts) as mediators of diabetic vascular complications. In the present s...

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Veröffentlicht in:	British journal of pharmacology 2005-09, Vol.146 (2), p.268-279
Hauptverfasser:	Nevado, Julián, Peiró, Concepción, Vallejo, Susana, El-Assar, Mariam, Lafuente, Nuria, Matesanz, Nuria, Azcutia, Verónica, Cercas, Elena, Sánchez-Ferrer, Carlos F, Rodríguez-Mañas, Leocadio
Format:	Artikel
Sprache:	eng
Schlagworte:	Blotting, Western Cells, Cultured Cytokines - biosynthesis Cytokines - genetics Electrophoretic Mobility Shift Assay Epithelial Cells - drug effects Epithelium - drug effects Gene Expression - drug effects Glycated Hemoglobin A - pharmacology Glycation End Products, Advanced - pharmacology Humans Inflammation - genetics Luciferases - metabolism NF-kappa B - genetics NF-kappa B - physiology Nitric Oxide - physiology Nitrites - metabolism Peritoneum - cytology Peritoneum - drug effects Plasmids - genetics Reactive Oxygen Species - metabolism Reverse Transcriptase Polymerase Chain Reaction Transfection
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