Adiponectin Multimerization Is Dependent on Conserved Lysines in the Collagenous Domain: Evidence for Regulation of Multimerization by Alterations in Posttranslational Modifications

Adiponectin is a secreted, multimeric protein with insulin-sensitizing, antiatherogenic, and antiinflammatory properties. Serum adiponectin consists of trimer, hexamer, and larger high-molecular-weight (HMW) multimers, and these HMW multimers appear to be the more bioactive forms. Multimer compositi...

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Veröffentlicht in:	Molecular endocrinology (Baltimore, Md.) Md.), 2006-07, Vol.20 (7), p.1673-1687
Hauptverfasser:	Richards, Ayanthi A, Stephens, Tim, Charlton, Hayley K, Jones, Alun, Macdonald, Graeme A, Prins, Johannes B, Whitehead, Jonathan P
Format:	Artikel
Sprache:	eng
Schlagworte:	2,2'-Dipyridyl - pharmacology Adiponectin - chemistry Adiponectin - metabolism Amino Acid Sequence Animals Bacteria - genetics Bacteria - metabolism CHO Cells Collagen - metabolism Conserved Sequence Cricetinae Dimerization Gene Expression Glucose - pharmacology Glycosylation Humans Hydroxylation - drug effects Lysine - metabolism Mass Spectrometry Models, Biological Molecular Sequence Data Multiprotein Complexes - metabolism Proline - metabolism Protein Isoforms - metabolism Protein Processing, Post-Translational Protein Structure, Tertiary Recombinant Proteins - chemistry
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