Biflavonoids from Brazilian pine Araucaria angustifolia as potentials protective agents against DNA damage and lipoperoxidation
Biflavonoids from Araucaria angustifolia were able to protect against DNA damage and lipoperoxidation promoved by reactive species (RNOS). The 1O 2 quenching rate constant using the time-resolved near infrared luminescence technique was also determined. A biflavonoid fraction (BFF) obtained from Ara...
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| Veröffentlicht in: | Phytochemistry 2005-09, Vol.66 (18), p.2238-2247 |
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| creator | Yamaguchi, Lydia F. Vassão, Daniel G. Kato, Massuo J. Di Mascio, Paolo |
| description | Biflavonoids from
Araucaria angustifolia were able to protect against DNA damage and lipoperoxidation promoved by reactive species (RNOS). The
1O
2 quenching rate constant using the time-resolved near infrared luminescence technique was also determined.
A biflavonoid fraction (BFF) obtained from
Araucaria angustifolia needles was effective to quench singlet oxygen (
1O
2), to protect plasmid DNA against single strand break (ssb) caused by
1O
2 or Fenton reaction and to inhibit Fenton or UV radiation-induced lipoperoxidation in phosphatidylcholine liposomes. The activity of the biflavonoid fraction (BFF) was compared with quercetin, rutin (flavonoids), ginkgetin, amentoflavone (biflavonoids), α-tocopherol and Trolox
®. The BFF displayed a higher quenching rate constant compared to flavonoids and biflavonoids and protected against ssb induced by
1O
2. Although the BFF was not as efficient as either flavonoids, α-tocopherol or Trolox
® in protection against ssb induced by Fenton-reaction or lipoperoxidation, these scavenging properties suggest that BFF is still an excellent candidate for successful employment as an antioxidant and photoprotector. |
| doi_str_mv | 10.1016/j.phytochem.2004.11.014 |
| format | Article |
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Araucaria angustifolia were able to protect against DNA damage and lipoperoxidation promoved by reactive species (RNOS). The
1O
2 quenching rate constant using the time-resolved near infrared luminescence technique was also determined.
A biflavonoid fraction (BFF) obtained from
Araucaria angustifolia needles was effective to quench singlet oxygen (
1O
2), to protect plasmid DNA against single strand break (ssb) caused by
1O
2 or Fenton reaction and to inhibit Fenton or UV radiation-induced lipoperoxidation in phosphatidylcholine liposomes. The activity of the biflavonoid fraction (BFF) was compared with quercetin, rutin (flavonoids), ginkgetin, amentoflavone (biflavonoids), α-tocopherol and Trolox
®. The BFF displayed a higher quenching rate constant compared to flavonoids and biflavonoids and protected against ssb induced by
1O
2. Although the BFF was not as efficient as either flavonoids, α-tocopherol or Trolox
® in protection against ssb induced by Fenton-reaction or lipoperoxidation, these scavenging properties suggest that BFF is still an excellent candidate for successful employment as an antioxidant and photoprotector.</description><identifier>ISSN: 0031-9422</identifier><identifier>EISSN: 1873-3700</identifier><identifier>DOI: 10.1016/j.phytochem.2004.11.014</identifier><identifier>PMID: 16153416</identifier><language>eng</language><publisher>Amsterdam: Elsevier Ltd</publisher><subject>Amentoflavone ; Araucaria angustifolia ; Araucariacea ; Biflavonoids ; Biological and medical sciences ; Brazil ; Chemical constitution ; conifer needles ; conifers ; DNA damage ; DNA Damage - drug effects ; DNA Damage - radiation effects ; flavonoids ; Flavonoids - chemistry ; Flavonoids - isolation & purification ; Flavonoids - metabolism ; Flavonoids - pharmacology ; Fundamental and applied biological sciences. Psychology ; General pharmacology ; Ginkgetin ; Hydrogen Peroxide - chemistry ; Iron - chemistry ; lipid peroxidation ; Lipid Peroxidation - drug effects ; Lipoperoxidation ; Liposomes - chemistry ; Liposomes - metabolism ; Medical sciences ; Methylation ; Molecular Structure ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Photoprotection ; phytochemicals ; Pinaceae - chemistry ; plant biochemistry ; plant extracts ; Plant Leaves - chemistry ; Plant physiology and development ; Plasmid DNA ; Plasmids - chemistry ; Plasmids - drug effects ; Singlet oxygen ; Singlet Oxygen - metabolism ; spectral analysis ; UV radiation</subject><ispartof>Phytochemistry, 2005-09, Vol.66 (18), p.2238-2247</ispartof><rights>2004 Elsevier Ltd</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c423t-fc7f11e87d8b24b067c0a4bda5d935d24c034e2941b0c36c30b7d28c316f29f63</citedby><cites>FETCH-LOGICAL-c423t-fc7f11e87d8b24b067c0a4bda5d935d24c034e2941b0c36c30b7d28c316f29f63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.phytochem.2004.11.014$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>309,310,314,780,784,789,790,3550,23930,23931,25140,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17158198$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16153416$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yamaguchi, Lydia F.</creatorcontrib><creatorcontrib>Vassão, Daniel G.</creatorcontrib><creatorcontrib>Kato, Massuo J.</creatorcontrib><creatorcontrib>Di Mascio, Paolo</creatorcontrib><title>Biflavonoids from Brazilian pine Araucaria angustifolia as potentials protective agents against DNA damage and lipoperoxidation</title><title>Phytochemistry</title><addtitle>Phytochemistry</addtitle><description>Biflavonoids from
Araucaria angustifolia were able to protect against DNA damage and lipoperoxidation promoved by reactive species (RNOS). The
1O
2 quenching rate constant using the time-resolved near infrared luminescence technique was also determined.
A biflavonoid fraction (BFF) obtained from
Araucaria angustifolia needles was effective to quench singlet oxygen (
1O
2), to protect plasmid DNA against single strand break (ssb) caused by
1O
2 or Fenton reaction and to inhibit Fenton or UV radiation-induced lipoperoxidation in phosphatidylcholine liposomes. The activity of the biflavonoid fraction (BFF) was compared with quercetin, rutin (flavonoids), ginkgetin, amentoflavone (biflavonoids), α-tocopherol and Trolox
®. The BFF displayed a higher quenching rate constant compared to flavonoids and biflavonoids and protected against ssb induced by
1O
2. Although the BFF was not as efficient as either flavonoids, α-tocopherol or Trolox
® in protection against ssb induced by Fenton-reaction or lipoperoxidation, these scavenging properties suggest that BFF is still an excellent candidate for successful employment as an antioxidant and photoprotector.</description><subject>Amentoflavone</subject><subject>Araucaria angustifolia</subject><subject>Araucariacea</subject><subject>Biflavonoids</subject><subject>Biological and medical sciences</subject><subject>Brazil</subject><subject>Chemical constitution</subject><subject>conifer needles</subject><subject>conifers</subject><subject>DNA damage</subject><subject>DNA Damage - drug effects</subject><subject>DNA Damage - radiation effects</subject><subject>flavonoids</subject><subject>Flavonoids - chemistry</subject><subject>Flavonoids - isolation & purification</subject><subject>Flavonoids - metabolism</subject><subject>Flavonoids - pharmacology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General pharmacology</subject><subject>Ginkgetin</subject><subject>Hydrogen Peroxide - chemistry</subject><subject>Iron - chemistry</subject><subject>lipid peroxidation</subject><subject>Lipid Peroxidation - drug effects</subject><subject>Lipoperoxidation</subject><subject>Liposomes - chemistry</subject><subject>Liposomes - metabolism</subject><subject>Medical sciences</subject><subject>Methylation</subject><subject>Molecular Structure</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Photoprotection</subject><subject>phytochemicals</subject><subject>Pinaceae - chemistry</subject><subject>plant biochemistry</subject><subject>plant extracts</subject><subject>Plant Leaves - chemistry</subject><subject>Plant physiology and development</subject><subject>Plasmid DNA</subject><subject>Plasmids - chemistry</subject><subject>Plasmids - drug effects</subject><subject>Singlet oxygen</subject><subject>Singlet Oxygen - metabolism</subject><subject>spectral analysis</subject><subject>UV radiation</subject><issn>0031-9422</issn><issn>1873-3700</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAQhiMEokvhL9Bc4JYwEztOctyWT6mCA_RsTfyx9SqJg52sKBf-Ol7tih45zXj0vDOvXmfZFUKJgOLdvpzvHxav7s1YVgC8RCwB-ZNsg23DCtYAPM02AAyLjlfVRfYixj0A1LUQz7MLFFgzjmKT_bl2dqCDn7zTMbfBj_l1oN9ucDTls5tMvg20KgqOcpp2a1yc9cPxEfPZL2ZaHA2pDalXizuYnHZpGFMhN8Ulf_91m2sa0zTpdT642c8m-F9O0-L89DJ7ZtMC8-pcL7O7jx9-3Hwubr99-nKzvS0Ur9hSWNVYRNM2uu0r3oNoFBDvNdW6Y7WuuALGTdVx7EExoRj0ja5axVDYqrOCXWZvT3uT05-riYscXVRmGGgyfo1StHULHCGBzQlUwccYjJVzcCOFB4kgj9nLvfyXvTxmLxFlyj4pX59PrP1o9KPuHHYC3pwBiooGG2hSLj5yDdYtdm3irk6cJS9pFxJz970CZJD81aI7btqeCJMiOzgTZFTOTMpoF9I3SO3df-3-BRwCsqQ</recordid><startdate>20050901</startdate><enddate>20050901</enddate><creator>Yamaguchi, Lydia F.</creator><creator>Vassão, Daniel G.</creator><creator>Kato, Massuo J.</creator><creator>Di Mascio, Paolo</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20050901</creationdate><title>Biflavonoids from Brazilian pine Araucaria angustifolia as potentials protective agents against DNA damage and lipoperoxidation</title><author>Yamaguchi, Lydia F. ; Vassão, Daniel G. ; Kato, Massuo J. ; Di Mascio, Paolo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c423t-fc7f11e87d8b24b067c0a4bda5d935d24c034e2941b0c36c30b7d28c316f29f63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Amentoflavone</topic><topic>Araucaria angustifolia</topic><topic>Araucariacea</topic><topic>Biflavonoids</topic><topic>Biological and medical sciences</topic><topic>Brazil</topic><topic>Chemical constitution</topic><topic>conifer needles</topic><topic>conifers</topic><topic>DNA damage</topic><topic>DNA Damage - drug effects</topic><topic>DNA Damage - radiation effects</topic><topic>flavonoids</topic><topic>Flavonoids - chemistry</topic><topic>Flavonoids - isolation & purification</topic><topic>Flavonoids - metabolism</topic><topic>Flavonoids - pharmacology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>General pharmacology</topic><topic>Ginkgetin</topic><topic>Hydrogen Peroxide - chemistry</topic><topic>Iron - chemistry</topic><topic>lipid peroxidation</topic><topic>Lipid Peroxidation - drug effects</topic><topic>Lipoperoxidation</topic><topic>Liposomes - chemistry</topic><topic>Liposomes - metabolism</topic><topic>Medical sciences</topic><topic>Methylation</topic><topic>Molecular Structure</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Photoprotection</topic><topic>phytochemicals</topic><topic>Pinaceae - chemistry</topic><topic>plant biochemistry</topic><topic>plant extracts</topic><topic>Plant Leaves - chemistry</topic><topic>Plant physiology and development</topic><topic>Plasmid DNA</topic><topic>Plasmids - chemistry</topic><topic>Plasmids - drug effects</topic><topic>Singlet oxygen</topic><topic>Singlet Oxygen - metabolism</topic><topic>spectral analysis</topic><topic>UV radiation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yamaguchi, Lydia F.</creatorcontrib><creatorcontrib>Vassão, Daniel G.</creatorcontrib><creatorcontrib>Kato, Massuo J.</creatorcontrib><creatorcontrib>Di Mascio, Paolo</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Phytochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yamaguchi, Lydia F.</au><au>Vassão, Daniel G.</au><au>Kato, Massuo J.</au><au>Di Mascio, Paolo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biflavonoids from Brazilian pine Araucaria angustifolia as potentials protective agents against DNA damage and lipoperoxidation</atitle><jtitle>Phytochemistry</jtitle><addtitle>Phytochemistry</addtitle><date>2005-09-01</date><risdate>2005</risdate><volume>66</volume><issue>18</issue><spage>2238</spage><epage>2247</epage><pages>2238-2247</pages><issn>0031-9422</issn><eissn>1873-3700</eissn><abstract>Biflavonoids from
Araucaria angustifolia were able to protect against DNA damage and lipoperoxidation promoved by reactive species (RNOS). The
1O
2 quenching rate constant using the time-resolved near infrared luminescence technique was also determined.
A biflavonoid fraction (BFF) obtained from
Araucaria angustifolia needles was effective to quench singlet oxygen (
1O
2), to protect plasmid DNA against single strand break (ssb) caused by
1O
2 or Fenton reaction and to inhibit Fenton or UV radiation-induced lipoperoxidation in phosphatidylcholine liposomes. The activity of the biflavonoid fraction (BFF) was compared with quercetin, rutin (flavonoids), ginkgetin, amentoflavone (biflavonoids), α-tocopherol and Trolox
®. The BFF displayed a higher quenching rate constant compared to flavonoids and biflavonoids and protected against ssb induced by
1O
2. Although the BFF was not as efficient as either flavonoids, α-tocopherol or Trolox
® in protection against ssb induced by Fenton-reaction or lipoperoxidation, these scavenging properties suggest that BFF is still an excellent candidate for successful employment as an antioxidant and photoprotector.</abstract><cop>Amsterdam</cop><pub>Elsevier Ltd</pub><pmid>16153416</pmid><doi>10.1016/j.phytochem.2004.11.014</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Phytochemistry, 2005-09, Vol.66 (18), p.2238-2247 |
| issn | 0031-9422 1873-3700 |
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| subjects | Amentoflavone Araucaria angustifolia Araucariacea Biflavonoids Biological and medical sciences Brazil Chemical constitution conifer needles conifers DNA damage DNA Damage - drug effects DNA Damage - radiation effects flavonoids Flavonoids - chemistry Flavonoids - isolation & purification Flavonoids - metabolism Flavonoids - pharmacology Fundamental and applied biological sciences. Psychology General pharmacology Ginkgetin Hydrogen Peroxide - chemistry Iron - chemistry lipid peroxidation Lipid Peroxidation - drug effects Lipoperoxidation Liposomes - chemistry Liposomes - metabolism Medical sciences Methylation Molecular Structure Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Photoprotection phytochemicals Pinaceae - chemistry plant biochemistry plant extracts Plant Leaves - chemistry Plant physiology and development Plasmid DNA Plasmids - chemistry Plasmids - drug effects Singlet oxygen Singlet Oxygen - metabolism spectral analysis UV radiation |
| title | Biflavonoids from Brazilian pine Araucaria angustifolia as potentials protective agents against DNA damage and lipoperoxidation |
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