Adeno-associated virus-mediated expression and constitutive secretion of galanin suppresses limbic seizure activity in vivo

Intractable temporal lobe epilepsy presents an ideal target for gene therapy, but therapeutic success depends upon the ability to suppress limbic seizure activity. Adeno-associated virus vectors (AAV) were constructed in which the fibronectin secretory signal sequence (FIB) preceded the coding seque...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Molecular therapy 2006-07, Vol.14 (1), p.63-68
1. Verfasser:	McCown, Thomas J
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Animals Behavior Cerebral Cortex - drug effects Cerebral Cortex - metabolism Cerebral Cortex - physiopathology Convulsions & seizures Dependovirus - genetics Electroencephalography - methods Epilepsy Fibronectins - genetics Fibronectins - metabolism Galanin - genetics Galanin - metabolism Galanin - secretion Gene expression Gene Expression - genetics Gene therapy Genetic Therapy - methods Genetic Vectors - administration & dosage Genetic Vectors - genetics Green Fluorescent Proteins - genetics Green Fluorescent Proteins - metabolism Infusion Pumps Kainic Acid - metabolism Kainic Acid - pharmacology Localization Male Neuropeptides Peptides Proteins Rats Rats, Sprague-Dawley Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics RNA, Messenger - metabolism Seizures - genetics Seizures - physiopathology Seizures - therapy Vectors (Biology)
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!