The influence of surfactant on PLGA microsphere glass transition and water sorption : Remodeling the surface morphology to attenuate the burst release

The stability of protein unloaded and loaded poly(lactic-co-glycolic acid) (PLGA) microspheres fabricated with surfactant was challenged through exposure to environmental conditions of different relative humidity. Polyvinyl alcohol (PVA) or Triton X-100 was added to the primary emulsion of the doubl...

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Veröffentlicht in:	Pharmaceutical research 2006-06, Vol.23 (6), p.1295-1305
Hauptverfasser:	BOUISSOU, C, ROUSE, J. J, PRICE, R, VAN DER WALLE, C. F
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Delayed-Action Preparations Drug Carriers Drug Compounding Fibronectins - chemistry General pharmacology Humidity Lactic Acid - chemistry Medical sciences Microspheres Morphology Octoxynol - chemistry Particle Size Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Physical properties Polyglycolic Acid - chemistry Polymers Polymers - chemistry Polyvinyl alcohol Polyvinyl Alcohol - chemistry Porosity Proteins Solubility Solvents Surface Properties Surface-Active Agents - chemistry Surfactants Time Factors Transition Temperature Water - chemistry
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