Is there any sense in antisense editing?
Several recent studies have hypothesized that sense–antisense RNA-transcript pairs create dsRNA duplexes that undergo extensive A-to-I RNA editing. We studied human and mouse genomic antisense regions and found that the editing level in these areas is negligible. This observation questions the scope...
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| Veröffentlicht in: | Trends in genetics 2005-10, Vol.21 (10), p.544-547 |
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| container_title | Trends in genetics |
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| creator | Neeman, Yossef Dahary, Dvir Levanon, Erez Y. Sorek, Rotem Eisenberg, Eli |
| description | Several recent studies have hypothesized that sense–antisense RNA-transcript pairs create dsRNA duplexes that undergo extensive A-to-I RNA editing. We studied human and mouse genomic antisense regions and found that the editing level in these areas is negligible. This observation questions the scope of sense–antisense duplexes formation
in-vivo, which is the basis for several proposed regulatory mechanisms. |
| doi_str_mv | 10.1016/j.tig.2005.08.005 |
| format | Article |
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| source | MEDLINE; Elsevier ScienceDirect Journals Collection |
| subjects | Alu Elements - genetics Animals Base Sequence Biological and medical sciences Fundamental and applied biological sciences. Psychology Genetics of eukaryotes. Biological and molecular evolution Genomics - methods Humans Mice Molecular and cellular biology Molecular Sequence Data RNA Editing - genetics RNA, Antisense - genetics RNA, Double-Stranded - genetics |
| title | Is there any sense in antisense editing? |
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