Development and validation of a capillary electrophoresis method with laser-induced fluorescence detection for the determination of captopril in human urine and pharmaceutical preparations

This study describes the development of a CE method for the analysis of the antihypertensive drug captopril using LIF detection. The method is based on the derivatization of captopril with the fluorescent label 5‐iodoacetamidofluorescein. The optimization of the electrophoretic electrolyte compositi...

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Veröffentlicht in:	Electrophoresis 2006-06, Vol.27 (12), p.2310-2316
Hauptverfasser:	Pérez-Ruiz, Tomás, Martínez-Lozano, Carmen, Galera, Raquel
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Iodoacetamidofluorescein Angiotensin-Converting Enzyme Inhibitors - analysis Angiotensin-Converting Enzyme Inhibitors - urine Antihypertensive Agents - analysis Antihypertensive Agents - urine Captopril Captopril - analysis Captopril - urine Chemistry, Pharmaceutical Electrophoresis, Capillary - methods Humans Laser-induced fluorescence detection Lasers Pharmaceutical preparations Pharmaceutical Preparations - analysis Sensitivity and Specificity Spectrometry, Fluorescence Urine analysis
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