Reward and anxiety in genetic animal models of childhood depression
One of the most important criteria for major depressive disorder in adults and in children and adolescents as well, is the loss of interest in or pleasure from typically enjoyable experiences or activities: anhedonia. Anxiety is frequently co-morbid with depression. We examined reward and anxiety in...
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| Veröffentlicht in: | Behavioural brain research 2005-10, Vol.164 (1), p.1-10 |
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| creator | Malkesman, O. Braw, Y. Zagoory-Sharon, O. Golan, O. Lavi-Avnon, Y. Schroeder, M. Overstreet, D.H. Yadid, G. Weller, A. |
| description | One of the most important criteria for major depressive disorder in adults and in children and adolescents as well, is the loss of interest in or pleasure from typically enjoyable experiences or activities: anhedonia. Anxiety is frequently co-morbid with depression. We examined reward and anxiety in genetic animal models of childhood depression. Two different “depressed” lines were studied: the Flinders Sensitive Line (FSL) and their controls, Sprague–Dawley (SD) rats and the Wistar Kyoto (WKY) line and their controls, Wistar rats. Recently, we found that prepubertal rats (about 35 days old) from these lines exhibited increased immobility in the swim test, and abnormal social play observed after 24-h isolation. We hypothesized that FSL and WKY prepubertal rats will further show anhedonia in two different behavioral assays: the conditioned place preference test (CPP), examining the rewarding aspect of social interaction and the saccharin preference test. Behavior in the open field paradigm and freezing behavior in the CPP apparatus were also used as measures of anxiety. WKY, but not FSL prepubertal rats, consumed less of the saccharin solution compared to their control line. FSL, and WKY prepubertal rats found social interaction to be rewarding to a similar extent as their control lines, in the CPP test. Only the WKY rats showed anxiety in behavior in the open field and freezing behavior in the CPP paradigm. The results suggest that WKY prepubertal rats are anxious and sensitive to stress-induced anhedonia, while FSL prepubertal rats exhibit none of these symptoms. |
| doi_str_mv | 10.1016/j.bbr.2005.04.023 |
| format | Article |
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Anxiety is frequently co-morbid with depression. We examined reward and anxiety in genetic animal models of childhood depression. Two different “depressed” lines were studied: the Flinders Sensitive Line (FSL) and their controls, Sprague–Dawley (SD) rats and the Wistar Kyoto (WKY) line and their controls, Wistar rats. Recently, we found that prepubertal rats (about 35 days old) from these lines exhibited increased immobility in the swim test, and abnormal social play observed after 24-h isolation. We hypothesized that FSL and WKY prepubertal rats will further show anhedonia in two different behavioral assays: the conditioned place preference test (CPP), examining the rewarding aspect of social interaction and the saccharin preference test. Behavior in the open field paradigm and freezing behavior in the CPP apparatus were also used as measures of anxiety. WKY, but not FSL prepubertal rats, consumed less of the saccharin solution compared to their control line. FSL, and WKY prepubertal rats found social interaction to be rewarding to a similar extent as their control lines, in the CPP test. Only the WKY rats showed anxiety in behavior in the open field and freezing behavior in the CPP paradigm. The results suggest that WKY prepubertal rats are anxious and sensitive to stress-induced anhedonia, while FSL prepubertal rats exhibit none of these symptoms.</description><identifier>ISSN: 0166-4328</identifier><identifier>EISSN: 1872-7549</identifier><identifier>DOI: 10.1016/j.bbr.2005.04.023</identifier><identifier>PMID: 16055204</identifier><identifier>CODEN: BBREDI</identifier><language>eng</language><publisher>Shannon: Elsevier B.V</publisher><subject>Adult and adolescent clinical studies ; Age Factors ; Analysis of Variance ; Animals ; Anxiety ; Anxiety - complications ; Anxiety - genetics ; Behavioral psychophysiology ; Biological and medical sciences ; Child ; Childhood depression ; Conditioning, Classical - physiology ; Depression ; Depressive Disorder, Major - complications ; Depressive Disorder, Major - genetics ; Disease Models, Animal ; Exploratory Behavior - physiology ; Female ; Freezing Reaction, Cataleptic - physiology ; Fundamental and applied biological sciences. Psychology ; Humans ; Male ; Medical sciences ; Miscellaneous ; Mood disorders ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Psychopathology. Psychiatry ; Rats ; Rats, Inbred Strains ; Rats, Inbred WKY ; Rats, Sprague-Dawley ; Rats, Wistar ; Reward ; Sexual Maturation ; Social Behavior ; Species Specificity ; Stress, Psychological - complications ; Stress, Psychological - genetics ; Taste - genetics ; Taste - physiology</subject><ispartof>Behavioural brain research, 2005-10, Vol.164 (1), p.1-10</ispartof><rights>2005 Elsevier B.V.</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c412t-135b594ca1906ebb80d541a968242972e51ad22b7575b204aea1f0f2d25ce5573</citedby><cites>FETCH-LOGICAL-c412t-135b594ca1906ebb80d541a968242972e51ad22b7575b204aea1f0f2d25ce5573</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.bbr.2005.04.023$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17140082$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16055204$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Malkesman, O.</creatorcontrib><creatorcontrib>Braw, Y.</creatorcontrib><creatorcontrib>Zagoory-Sharon, O.</creatorcontrib><creatorcontrib>Golan, O.</creatorcontrib><creatorcontrib>Lavi-Avnon, Y.</creatorcontrib><creatorcontrib>Schroeder, M.</creatorcontrib><creatorcontrib>Overstreet, D.H.</creatorcontrib><creatorcontrib>Yadid, G.</creatorcontrib><creatorcontrib>Weller, A.</creatorcontrib><title>Reward and anxiety in genetic animal models of childhood depression</title><title>Behavioural brain research</title><addtitle>Behav Brain Res</addtitle><description>One of the most important criteria for major depressive disorder in adults and in children and adolescents as well, is the loss of interest in or pleasure from typically enjoyable experiences or activities: anhedonia. Anxiety is frequently co-morbid with depression. We examined reward and anxiety in genetic animal models of childhood depression. Two different “depressed” lines were studied: the Flinders Sensitive Line (FSL) and their controls, Sprague–Dawley (SD) rats and the Wistar Kyoto (WKY) line and their controls, Wistar rats. Recently, we found that prepubertal rats (about 35 days old) from these lines exhibited increased immobility in the swim test, and abnormal social play observed after 24-h isolation. We hypothesized that FSL and WKY prepubertal rats will further show anhedonia in two different behavioral assays: the conditioned place preference test (CPP), examining the rewarding aspect of social interaction and the saccharin preference test. Behavior in the open field paradigm and freezing behavior in the CPP apparatus were also used as measures of anxiety. WKY, but not FSL prepubertal rats, consumed less of the saccharin solution compared to their control line. FSL, and WKY prepubertal rats found social interaction to be rewarding to a similar extent as their control lines, in the CPP test. Only the WKY rats showed anxiety in behavior in the open field and freezing behavior in the CPP paradigm. The results suggest that WKY prepubertal rats are anxious and sensitive to stress-induced anhedonia, while FSL prepubertal rats exhibit none of these symptoms.</description><subject>Adult and adolescent clinical studies</subject><subject>Age Factors</subject><subject>Analysis of Variance</subject><subject>Animals</subject><subject>Anxiety</subject><subject>Anxiety - complications</subject><subject>Anxiety - genetics</subject><subject>Behavioral psychophysiology</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Childhood depression</subject><subject>Conditioning, Classical - physiology</subject><subject>Depression</subject><subject>Depressive Disorder, Major - complications</subject><subject>Depressive Disorder, Major - genetics</subject><subject>Disease Models, Animal</subject><subject>Exploratory Behavior - physiology</subject><subject>Female</subject><subject>Freezing Reaction, Cataleptic - physiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Miscellaneous</subject><subject>Mood disorders</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Psychopathology. Psychiatry</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Rats, Inbred WKY</subject><subject>Rats, Sprague-Dawley</subject><subject>Rats, Wistar</subject><subject>Reward</subject><subject>Sexual Maturation</subject><subject>Social Behavior</subject><subject>Species Specificity</subject><subject>Stress, Psychological - complications</subject><subject>Stress, Psychological - genetics</subject><subject>Taste - genetics</subject><subject>Taste - physiology</subject><issn>0166-4328</issn><issn>1872-7549</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LxDAQhoMoun78AC_Si95aJ2nStHiSxS8QBNFzSJOpZuk2a9JV99-bZRe86WEYGJ53mHkIOaVQUKDV5axo21AwAFEAL4CVO2RCa8lyKXizSyaJqXJesvqAHMY4AwAOgu6TA1qBEAz4hEyf8UsHm-lhXd8Ox1XmhuwNBxydSSM313029xb7mPkuM--ut-_e28ziImCMzg_HZK_TfcSTbT8ir7c3L9P7_PHp7mF6_ZgbTtmY01K0ouFG0wYqbNsarOBUN1XNOGskQ0G1ZayVQoo2HadR0w46ZpkwKIQsj8jFZu8i-I8lxlHNXTTY93pAv4yqqoWsoOb_glSWjawbkUC6AU3wMQbs1CKkh8NKUVBrxWqmkmK1VqyAq6Q4Zc62y5ftHO1vYus0AedbQEej-y7owbj4y0nKAWqWuKsNl9Tip8OgonE4GLQuoBmV9e6PM34ActOXUw</recordid><startdate>20051014</startdate><enddate>20051014</enddate><creator>Malkesman, O.</creator><creator>Braw, Y.</creator><creator>Zagoory-Sharon, O.</creator><creator>Golan, O.</creator><creator>Lavi-Avnon, Y.</creator><creator>Schroeder, M.</creator><creator>Overstreet, D.H.</creator><creator>Yadid, G.</creator><creator>Weller, A.</creator><general>Elsevier B.V</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20051014</creationdate><title>Reward and anxiety in genetic animal models of childhood depression</title><author>Malkesman, O. ; Braw, Y. ; Zagoory-Sharon, O. ; Golan, O. ; Lavi-Avnon, Y. ; Schroeder, M. ; Overstreet, D.H. ; Yadid, G. ; Weller, A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c412t-135b594ca1906ebb80d541a968242972e51ad22b7575b204aea1f0f2d25ce5573</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult and adolescent clinical studies</topic><topic>Age Factors</topic><topic>Analysis of Variance</topic><topic>Animals</topic><topic>Anxiety</topic><topic>Anxiety - complications</topic><topic>Anxiety - genetics</topic><topic>Behavioral psychophysiology</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Childhood depression</topic><topic>Conditioning, Classical - physiology</topic><topic>Depression</topic><topic>Depressive Disorder, Major - complications</topic><topic>Depressive Disorder, Major - genetics</topic><topic>Disease Models, Animal</topic><topic>Exploratory Behavior - physiology</topic><topic>Female</topic><topic>Freezing Reaction, Cataleptic - physiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Miscellaneous</topic><topic>Mood disorders</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Psychopathology. Psychiatry</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Rats, Inbred WKY</topic><topic>Rats, Sprague-Dawley</topic><topic>Rats, Wistar</topic><topic>Reward</topic><topic>Sexual Maturation</topic><topic>Social Behavior</topic><topic>Species Specificity</topic><topic>Stress, Psychological - complications</topic><topic>Stress, Psychological - genetics</topic><topic>Taste - genetics</topic><topic>Taste - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Malkesman, O.</creatorcontrib><creatorcontrib>Braw, Y.</creatorcontrib><creatorcontrib>Zagoory-Sharon, O.</creatorcontrib><creatorcontrib>Golan, O.</creatorcontrib><creatorcontrib>Lavi-Avnon, Y.</creatorcontrib><creatorcontrib>Schroeder, M.</creatorcontrib><creatorcontrib>Overstreet, D.H.</creatorcontrib><creatorcontrib>Yadid, G.</creatorcontrib><creatorcontrib>Weller, A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Behavioural brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Malkesman, O.</au><au>Braw, Y.</au><au>Zagoory-Sharon, O.</au><au>Golan, O.</au><au>Lavi-Avnon, Y.</au><au>Schroeder, M.</au><au>Overstreet, D.H.</au><au>Yadid, G.</au><au>Weller, A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reward and anxiety in genetic animal models of childhood depression</atitle><jtitle>Behavioural brain research</jtitle><addtitle>Behav Brain Res</addtitle><date>2005-10-14</date><risdate>2005</risdate><volume>164</volume><issue>1</issue><spage>1</spage><epage>10</epage><pages>1-10</pages><issn>0166-4328</issn><eissn>1872-7549</eissn><coden>BBREDI</coden><abstract>One of the most important criteria for major depressive disorder in adults and in children and adolescents as well, is the loss of interest in or pleasure from typically enjoyable experiences or activities: anhedonia. Anxiety is frequently co-morbid with depression. We examined reward and anxiety in genetic animal models of childhood depression. Two different “depressed” lines were studied: the Flinders Sensitive Line (FSL) and their controls, Sprague–Dawley (SD) rats and the Wistar Kyoto (WKY) line and their controls, Wistar rats. Recently, we found that prepubertal rats (about 35 days old) from these lines exhibited increased immobility in the swim test, and abnormal social play observed after 24-h isolation. We hypothesized that FSL and WKY prepubertal rats will further show anhedonia in two different behavioral assays: the conditioned place preference test (CPP), examining the rewarding aspect of social interaction and the saccharin preference test. Behavior in the open field paradigm and freezing behavior in the CPP apparatus were also used as measures of anxiety. WKY, but not FSL prepubertal rats, consumed less of the saccharin solution compared to their control line. FSL, and WKY prepubertal rats found social interaction to be rewarding to a similar extent as their control lines, in the CPP test. Only the WKY rats showed anxiety in behavior in the open field and freezing behavior in the CPP paradigm. The results suggest that WKY prepubertal rats are anxious and sensitive to stress-induced anhedonia, while FSL prepubertal rats exhibit none of these symptoms.</abstract><cop>Shannon</cop><pub>Elsevier B.V</pub><pmid>16055204</pmid><doi>10.1016/j.bbr.2005.04.023</doi><tpages>10</tpages></addata></record> |
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| subjects | Adult and adolescent clinical studies Age Factors Analysis of Variance Animals Anxiety Anxiety - complications Anxiety - genetics Behavioral psychophysiology Biological and medical sciences Child Childhood depression Conditioning, Classical - physiology Depression Depressive Disorder, Major - complications Depressive Disorder, Major - genetics Disease Models, Animal Exploratory Behavior - physiology Female Freezing Reaction, Cataleptic - physiology Fundamental and applied biological sciences. Psychology Humans Male Medical sciences Miscellaneous Mood disorders Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Psychopathology. Psychiatry Rats Rats, Inbred Strains Rats, Inbred WKY Rats, Sprague-Dawley Rats, Wistar Reward Sexual Maturation Social Behavior Species Specificity Stress, Psychological - complications Stress, Psychological - genetics Taste - genetics Taste - physiology |
| title | Reward and anxiety in genetic animal models of childhood depression |
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