Nrf2 Controls Constitutive and Inducible Expression of ARE-driven Genes through a Dynamic Pathway Involving Nucleocytoplasmic Shuttling by Keap1

Nrf2 regulates the expression of genes encoding antioxidant proteins involved in cellular redox homeostasis. Previous studies have suggested that activation of Nrf2 is mediated by mechanisms promoting its dissociation from Keap1, a cytosolic repressor that acts to sequester the transcription factor...

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Veröffentlicht in:	The Journal of biological chemistry 2005-09, Vol.280 (37), p.32485-32492
Hauptverfasser:	Nguyen, Truyen, Sherratt, Philip J., Nioi, Paul, Yang, Chung S., Pickett, Cecil B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Active Transport, Cell Nucleus Animals Antioxidants - pharmacology Cell Line, Tumor Cell Nucleus - metabolism Chromatin - metabolism Chromatin Immunoprecipitation Cytoplasm - metabolism Cytosol - metabolism DNA-Binding Proteins - chemistry DNA-Binding Proteins - physiology Gene Expression Regulation Glutathione Transferase - metabolism Green Fluorescent Proteins - metabolism Humans Immunoblotting Immunohistochemistry Immunoprecipitation Intracellular Signaling Peptides and Proteins Kelch-Like ECH-Associated Protein 1 Microscopy, Confocal Models, Biological NF-E2-Related Factor 2 Oxidation-Reduction Protein Binding Protein Transport Proteins - metabolism Proteins - physiology Rats Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - metabolism Subcellular Fractions - metabolism Time Factors Trans-Activators - chemistry Trans-Activators - physiology Ubiquitin - chemistry Ubiquitin - metabolism
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