Characteristics of Epstein-Barr virus associated childhood non-Hodgkin's lymphoma in the Republic of Korea
To analyze the clinicopathologic characteristics of childhood non-Hodgkin's lymphoma (NHL) associated with Epstein-Barr virus (EBV), EBER in situ hybridization was performed in 80 cases of NHLs. EBER-positive lymphomas account for 25% (20/80) and include NK/T-cell lymphoma (6/6), aggressive NK-...
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| Veröffentlicht in: | Virchows Archiv : an international journal of pathology 2005-09, Vol.447 (3), p.593-596 |
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| container_title | Virchows Archiv : an international journal of pathology |
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| creator | KIM, Donghoon KO, Younghyeh SUH, Yeonlim KOO, Honghoe HUH, Jooryung LEE, Wonkeun |
| description | To analyze the clinicopathologic characteristics of childhood non-Hodgkin's lymphoma (NHL) associated with Epstein-Barr virus (EBV), EBER in situ hybridization was performed in 80 cases of NHLs. EBER-positive lymphomas account for 25% (20/80) and include NK/T-cell lymphoma (6/6), aggressive NK-cell leukemia (1/1), peripheral T cell lymphoma (5/11), diffuse large B-cell lymphoma (5/14), hydroa-like T-cell lymphoma (1/1), marginal zone B-cell lymphoma (1/2), and post-transplantation lymphoproliferative disorder (1/1). Other types including 19 cases of Burkitt's lymphoma were negative. For 9 EBER-positive cases, immunohistochemical staining for LMP-1, and EBNA-2 was performed to determine the EBV latency pattern. Two of nine EBER-positive cases expressed both LMP-1 and EBNA-2. Clinically, patients with EBV-positive B-cell lymphomas were cured with chemotherapy, whereas EBV-associated NK- and T cell lymphomas pursued fatal clinical course. In conclusion, EBVs infected in childhood NHLs are frequently associated not only with NK- and T- cell lymphomas but also large B-cell lymphomas. |
| doi_str_mv | 10.1007/s00428-005-1277-4 |
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EBER-positive lymphomas account for 25% (20/80) and include NK/T-cell lymphoma (6/6), aggressive NK-cell leukemia (1/1), peripheral T cell lymphoma (5/11), diffuse large B-cell lymphoma (5/14), hydroa-like T-cell lymphoma (1/1), marginal zone B-cell lymphoma (1/2), and post-transplantation lymphoproliferative disorder (1/1). Other types including 19 cases of Burkitt's lymphoma were negative. For 9 EBER-positive cases, immunohistochemical staining for LMP-1, and EBNA-2 was performed to determine the EBV latency pattern. Two of nine EBER-positive cases expressed both LMP-1 and EBNA-2. Clinically, patients with EBV-positive B-cell lymphomas were cured with chemotherapy, whereas EBV-associated NK- and T cell lymphomas pursued fatal clinical course. In conclusion, EBVs infected in childhood NHLs are frequently associated not only with NK- and T- cell lymphomas but also large B-cell lymphomas.</description><identifier>ISSN: 0945-6317</identifier><identifier>EISSN: 1432-2307</identifier><identifier>DOI: 10.1007/s00428-005-1277-4</identifier><identifier>PMID: 15991005</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Adolescent ; Biological and medical sciences ; Cancer ; Child ; Epstein-Barr virus ; Epstein-Barr Virus Infections - epidemiology ; Epstein-Barr Virus Nuclear Antigens - biosynthesis ; Female ; Hematologic and hematopoietic diseases ; Herpesvirus 4, Human - physiology ; Humans ; Immunohistochemistry ; In Situ Hybridization ; Investigative techniques, diagnostic techniques (general aspects) ; Korea ; Leukemia ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Lymphoma ; Lymphoma, Non-Hodgkin - virology ; Male ; Medical sciences ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; Ribosomal Proteins - biosynthesis ; RNA-Binding Proteins - biosynthesis ; Sex Factors ; Tumor Virus Infections - epidemiology ; Viral Matrix Proteins - biosynthesis ; Viral Proteins ; Virus Latency</subject><ispartof>Virchows Archiv : an international journal of pathology, 2005-09, Vol.447 (3), p.593-596</ispartof><rights>2005 INIST-CNRS</rights><rights>Springer-Verlag 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c387t-d36dc3d1f767ab4095d398273c7b3e1c318538a748e066c8cbda7c6e41ce36f93</citedby><cites>FETCH-LOGICAL-c387t-d36dc3d1f767ab4095d398273c7b3e1c318538a748e066c8cbda7c6e41ce36f93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17118011$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15991005$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KIM, Donghoon</creatorcontrib><creatorcontrib>KO, Younghyeh</creatorcontrib><creatorcontrib>SUH, Yeonlim</creatorcontrib><creatorcontrib>KOO, Honghoe</creatorcontrib><creatorcontrib>HUH, Jooryung</creatorcontrib><creatorcontrib>LEE, Wonkeun</creatorcontrib><title>Characteristics of Epstein-Barr virus associated childhood non-Hodgkin's lymphoma in the Republic of Korea</title><title>Virchows Archiv : an international journal of pathology</title><addtitle>Virchows Arch</addtitle><description>To analyze the clinicopathologic characteristics of childhood non-Hodgkin's lymphoma (NHL) associated with Epstein-Barr virus (EBV), EBER in situ hybridization was performed in 80 cases of NHLs. EBER-positive lymphomas account for 25% (20/80) and include NK/T-cell lymphoma (6/6), aggressive NK-cell leukemia (1/1), peripheral T cell lymphoma (5/11), diffuse large B-cell lymphoma (5/14), hydroa-like T-cell lymphoma (1/1), marginal zone B-cell lymphoma (1/2), and post-transplantation lymphoproliferative disorder (1/1). Other types including 19 cases of Burkitt's lymphoma were negative. For 9 EBER-positive cases, immunohistochemical staining for LMP-1, and EBNA-2 was performed to determine the EBV latency pattern. Two of nine EBER-positive cases expressed both LMP-1 and EBNA-2. Clinically, patients with EBV-positive B-cell lymphomas were cured with chemotherapy, whereas EBV-associated NK- and T cell lymphomas pursued fatal clinical course. In conclusion, EBVs infected in childhood NHLs are frequently associated not only with NK- and T- cell lymphomas but also large B-cell lymphomas.</description><subject>Adolescent</subject><subject>Biological and medical sciences</subject><subject>Cancer</subject><subject>Child</subject><subject>Epstein-Barr virus</subject><subject>Epstein-Barr Virus Infections - epidemiology</subject><subject>Epstein-Barr Virus Nuclear Antigens - biosynthesis</subject><subject>Female</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Herpesvirus 4, Human - physiology</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>In Situ Hybridization</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Korea</subject><subject>Leukemia</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Lymphoma</subject><subject>Lymphoma, Non-Hodgkin - virology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><subject>Ribosomal Proteins - biosynthesis</subject><subject>RNA-Binding Proteins - biosynthesis</subject><subject>Sex Factors</subject><subject>Tumor Virus Infections - epidemiology</subject><subject>Viral Matrix Proteins - biosynthesis</subject><subject>Viral Proteins</subject><subject>Virus Latency</subject><issn>0945-6317</issn><issn>1432-2307</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkU2L1TAUQIMozpvRH-BGgqCuovc2bT6W-phxxAFBdB3SJLV5tk1NWmH-vX28BwNuXN3NuQfuPYS8QHiHAPJ9AagrxQAahpWUrH5EdljzilUc5GOyA103THCUF-SylANAhQrFU3KBjdabodmRw7632bol5FiW6ApNHb2eyxLixD7anOmfmNdCbSnJRbsET10fB9-n5OmUJnab_M9fcXpb6HA_zn0aLY0TXfpAv4V5bYfojsYvKQf7jDzp7FDC8_O8Ij9urr_vb9nd10-f9x_umONKLsxz4R332EkhbVuDbjzXqpLcyZYHdBxVw5WVtQoghFOu9VY6EWp0gYtO8yvy5uSdc_q9hrKYMRYXhsFOIa3FCNVIrrn6L4haC6jgCL76BzykNU_bEUZVIHnFa9ggPEEup1Jy6Myc42jzvUEwx1zmlMtsfzfHXKbedl6exWs7Bv-wce6zAa_PgC3ODl22k4vlgZOIChD5XzwnnL4</recordid><startdate>20050901</startdate><enddate>20050901</enddate><creator>KIM, Donghoon</creator><creator>KO, Younghyeh</creator><creator>SUH, Yeonlim</creator><creator>KOO, Honghoe</creator><creator>HUH, Jooryung</creator><creator>LEE, Wonkeun</creator><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7T7</scope><scope>7TM</scope><scope>7TO</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20050901</creationdate><title>Characteristics of Epstein-Barr virus associated childhood non-Hodgkin's lymphoma in the Republic of Korea</title><author>KIM, Donghoon ; KO, Younghyeh ; SUH, Yeonlim ; KOO, Honghoe ; HUH, Jooryung ; LEE, Wonkeun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c387t-d36dc3d1f767ab4095d398273c7b3e1c318538a748e066c8cbda7c6e41ce36f93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adolescent</topic><topic>Biological and medical sciences</topic><topic>Cancer</topic><topic>Child</topic><topic>Epstein-Barr virus</topic><topic>Epstein-Barr Virus Infections - epidemiology</topic><topic>Epstein-Barr Virus Nuclear Antigens - biosynthesis</topic><topic>Female</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Herpesvirus 4, Human - physiology</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>In Situ Hybridization</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Korea</topic><topic>Leukemia</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Lymphoma</topic><topic>Lymphoma, Non-Hodgkin - virology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pathology. Cytology. Biochemistry. Spectrometry. 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EBER-positive lymphomas account for 25% (20/80) and include NK/T-cell lymphoma (6/6), aggressive NK-cell leukemia (1/1), peripheral T cell lymphoma (5/11), diffuse large B-cell lymphoma (5/14), hydroa-like T-cell lymphoma (1/1), marginal zone B-cell lymphoma (1/2), and post-transplantation lymphoproliferative disorder (1/1). Other types including 19 cases of Burkitt's lymphoma were negative. For 9 EBER-positive cases, immunohistochemical staining for LMP-1, and EBNA-2 was performed to determine the EBV latency pattern. Two of nine EBER-positive cases expressed both LMP-1 and EBNA-2. Clinically, patients with EBV-positive B-cell lymphomas were cured with chemotherapy, whereas EBV-associated NK- and T cell lymphomas pursued fatal clinical course. In conclusion, EBVs infected in childhood NHLs are frequently associated not only with NK- and T- cell lymphomas but also large B-cell lymphomas.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>15991005</pmid><doi>10.1007/s00428-005-1277-4</doi><tpages>4</tpages></addata></record> |
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| subjects | Adolescent Biological and medical sciences Cancer Child Epstein-Barr virus Epstein-Barr Virus Infections - epidemiology Epstein-Barr Virus Nuclear Antigens - biosynthesis Female Hematologic and hematopoietic diseases Herpesvirus 4, Human - physiology Humans Immunohistochemistry In Situ Hybridization Investigative techniques, diagnostic techniques (general aspects) Korea Leukemia Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphoma Lymphoma, Non-Hodgkin - virology Male Medical sciences Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Ribosomal Proteins - biosynthesis RNA-Binding Proteins - biosynthesis Sex Factors Tumor Virus Infections - epidemiology Viral Matrix Proteins - biosynthesis Viral Proteins Virus Latency |
| title | Characteristics of Epstein-Barr virus associated childhood non-Hodgkin's lymphoma in the Republic of Korea |
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