Prognostic Significance of T Helper 1 and 2 and T Cytotoxic 1 and 2 Cells in Patients with Non-small Cell Lung Cancer
Background: We report the prognostic significance of peripheral and tumor-infiltrating Th1, Th2, Tc1 and Tc2 cells in lung cancer patients. Materials and Methods: We evaluated the rates of interferon (IFN)-γ+/CD4+ cells (Th1), interleukin (IL)-4+ /CD4+ cells (Th2), IFN-γ+/CD8+ cells (Tc1), IL-4+ /...
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| Veröffentlicht in: | Anticancer research 2005-05, Vol.25 (3B), p.2027-2031 |
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| creator | ITO, Norimasa SUZUKI, Yoshimasa TANIGUCHI, Yuji ISHIGURO, Kiyosuke NAKAMURA, Hiroshige OHGI, Shigetsugu |
| description | Background: We report the prognostic significance of peripheral and tumor-infiltrating Th1, Th2, Tc1 and Tc2 cells in lung
cancer patients. Materials and Methods: We evaluated the rates of interferon (IFN)-γ+/CD4+ cells (Th1), interleukin (IL)-4+
/CD4+ cells (Th2), IFN-γ+/CD8+ cells (Tc1), IL-4+ /CD8+ cells (Tc2), and the ratio of Th1 to Th2 and that of Tc1 to Tc2 among
peripheral blood lymphocytes (PBL) and tumor-infiltrating lymphocytes (TIL), in 51 consecutive patients with non-small cell
lung cancer, by detecting the intracellular cytokine production using three-color flow cytometry. Results: Patients with a
low Th1/Th2 ratio in peripheral blood lymphocytes had a significantly better prognosis than those with a high Th1/Th2 ratio
(5-year survival rate: low: 74.7% vs. high: 50.3%; p=0.038). Patients with a low Th1/Th2 ratio in peripheral blood had a significantly
better prognosis than those with a high Th1/Th2 ratio in pathological Stage II or III (5-year survival rate: low: 66.6% vs.
high: 18.2%; p=0.018). Conclusion: A high Th1/Th2 ratio in peripheral blood is a negative prognostic factor, especially in
pathological Stage II or III non-small cell lung cancer patients. |
| format | Article |
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cancer patients. Materials and Methods: We evaluated the rates of interferon (IFN)-γ+/CD4+ cells (Th1), interleukin (IL)-4+
/CD4+ cells (Th2), IFN-γ+/CD8+ cells (Tc1), IL-4+ /CD8+ cells (Tc2), and the ratio of Th1 to Th2 and that of Tc1 to Tc2 among
peripheral blood lymphocytes (PBL) and tumor-infiltrating lymphocytes (TIL), in 51 consecutive patients with non-small cell
lung cancer, by detecting the intracellular cytokine production using three-color flow cytometry. Results: Patients with a
low Th1/Th2 ratio in peripheral blood lymphocytes had a significantly better prognosis than those with a high Th1/Th2 ratio
(5-year survival rate: low: 74.7% vs. high: 50.3%; p=0.038). Patients with a low Th1/Th2 ratio in peripheral blood had a significantly
better prognosis than those with a high Th1/Th2 ratio in pathological Stage II or III (5-year survival rate: low: 66.6% vs.
high: 18.2%; p=0.018). Conclusion: A high Th1/Th2 ratio in peripheral blood is a negative prognostic factor, especially in
pathological Stage II or III non-small cell lung cancer patients.</description><identifier>ISSN: 0250-7005</identifier><identifier>EISSN: 1791-7530</identifier><identifier>PMID: 16158940</identifier><language>eng</language><publisher>Attiki: International Institute of Anticancer Research</publisher><subject>Aged ; Biological and medical sciences ; Carcinoma, Non-Small-Cell Lung - blood ; Carcinoma, Non-Small-Cell Lung - immunology ; Female ; Humans ; Lung Neoplasms - blood ; Lung Neoplasms - immunology ; Male ; Medical sciences ; Middle Aged ; Pneumology ; Prognosis ; T-Lymphocytes, Cytotoxic - immunology ; Th1 Cells - immunology ; Th2 Cells - immunology ; Tumors ; Tumors of the respiratory system and mediastinum</subject><ispartof>Anticancer research, 2005-05, Vol.25 (3B), p.2027-2031</ispartof><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16908599$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16158940$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ITO, Norimasa</creatorcontrib><creatorcontrib>SUZUKI, Yoshimasa</creatorcontrib><creatorcontrib>TANIGUCHI, Yuji</creatorcontrib><creatorcontrib>ISHIGURO, Kiyosuke</creatorcontrib><creatorcontrib>NAKAMURA, Hiroshige</creatorcontrib><creatorcontrib>OHGI, Shigetsugu</creatorcontrib><title>Prognostic Significance of T Helper 1 and 2 and T Cytotoxic 1 and 2 Cells in Patients with Non-small Cell Lung Cancer</title><title>Anticancer research</title><addtitle>Anticancer Res</addtitle><description>Background: We report the prognostic significance of peripheral and tumor-infiltrating Th1, Th2, Tc1 and Tc2 cells in lung
cancer patients. Materials and Methods: We evaluated the rates of interferon (IFN)-γ+/CD4+ cells (Th1), interleukin (IL)-4+
/CD4+ cells (Th2), IFN-γ+/CD8+ cells (Tc1), IL-4+ /CD8+ cells (Tc2), and the ratio of Th1 to Th2 and that of Tc1 to Tc2 among
peripheral blood lymphocytes (PBL) and tumor-infiltrating lymphocytes (TIL), in 51 consecutive patients with non-small cell
lung cancer, by detecting the intracellular cytokine production using three-color flow cytometry. Results: Patients with a
low Th1/Th2 ratio in peripheral blood lymphocytes had a significantly better prognosis than those with a high Th1/Th2 ratio
(5-year survival rate: low: 74.7% vs. high: 50.3%; p=0.038). Patients with a low Th1/Th2 ratio in peripheral blood had a significantly
better prognosis than those with a high Th1/Th2 ratio in pathological Stage II or III (5-year survival rate: low: 66.6% vs.
high: 18.2%; p=0.018). Conclusion: A high Th1/Th2 ratio in peripheral blood is a negative prognostic factor, especially in
pathological Stage II or III non-small cell lung cancer patients.</description><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Non-Small-Cell Lung - blood</subject><subject>Carcinoma, Non-Small-Cell Lung - immunology</subject><subject>Female</subject><subject>Humans</subject><subject>Lung Neoplasms - blood</subject><subject>Lung Neoplasms - immunology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pneumology</subject><subject>Prognosis</subject><subject>T-Lymphocytes, Cytotoxic - immunology</subject><subject>Th1 Cells - immunology</subject><subject>Th2 Cells - immunology</subject><subject>Tumors</subject><subject>Tumors of the respiratory system and mediastinum</subject><issn>0250-7005</issn><issn>1791-7530</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkF9LwzAUxYsobk6_guRF3wr50zTJoxZ1wtCB8zlkadpG2nQmKXPf3jo39OVeuPzuueeek2SKmEApowSeJlOIKUwZhHSSXITwAWGeC07OkwnKEeUig9NkWPq-dn2IVoM3WztbWa2cNqCvwArMTbsxHiCgXAnwvq5AsYt97L_GheO8MG0bgHVgqaI1LgawtbEBL71LQ6fadg-AxeBqUPyI-8vkrFJtMFeHPkveHx9WxTxdvD49F3eLtMEMxpRpXuqMqizjrCyxINTAUiiqIM4VXVcV5wzpLF_nJddMq8pAw8pMCIRzJHBFZsntr-7G95-DCVF2NujRjHKmH4LMOWWEZ2QErw_gsO5MKTfedsrv5DGoEbg5ACpo1VZ-_MOGf5yAnArxd7GxdbO13sh9AqMskcpjKsm9xBAz8g34Hn2g</recordid><startdate>20050501</startdate><enddate>20050501</enddate><creator>ITO, Norimasa</creator><creator>SUZUKI, Yoshimasa</creator><creator>TANIGUCHI, Yuji</creator><creator>ISHIGURO, Kiyosuke</creator><creator>NAKAMURA, Hiroshige</creator><creator>OHGI, Shigetsugu</creator><general>International Institute of Anticancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20050501</creationdate><title>Prognostic Significance of T Helper 1 and 2 and T Cytotoxic 1 and 2 Cells in Patients with Non-small Cell Lung Cancer</title><author>ITO, Norimasa ; SUZUKI, Yoshimasa ; TANIGUCHI, Yuji ; ISHIGURO, Kiyosuke ; NAKAMURA, Hiroshige ; OHGI, Shigetsugu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h270t-7c8dc45a4487dd2935e0d9a5a026a5bff8871c46b6d8c7cafe0e7d499126192f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Non-Small-Cell Lung - blood</topic><topic>Carcinoma, Non-Small-Cell Lung - immunology</topic><topic>Female</topic><topic>Humans</topic><topic>Lung Neoplasms - blood</topic><topic>Lung Neoplasms - immunology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pneumology</topic><topic>Prognosis</topic><topic>T-Lymphocytes, Cytotoxic - immunology</topic><topic>Th1 Cells - immunology</topic><topic>Th2 Cells - immunology</topic><topic>Tumors</topic><topic>Tumors of the respiratory system and mediastinum</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ITO, Norimasa</creatorcontrib><creatorcontrib>SUZUKI, Yoshimasa</creatorcontrib><creatorcontrib>TANIGUCHI, Yuji</creatorcontrib><creatorcontrib>ISHIGURO, Kiyosuke</creatorcontrib><creatorcontrib>NAKAMURA, Hiroshige</creatorcontrib><creatorcontrib>OHGI, Shigetsugu</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Anticancer research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ITO, Norimasa</au><au>SUZUKI, Yoshimasa</au><au>TANIGUCHI, Yuji</au><au>ISHIGURO, Kiyosuke</au><au>NAKAMURA, Hiroshige</au><au>OHGI, Shigetsugu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic Significance of T Helper 1 and 2 and T Cytotoxic 1 and 2 Cells in Patients with Non-small Cell Lung Cancer</atitle><jtitle>Anticancer research</jtitle><addtitle>Anticancer Res</addtitle><date>2005-05-01</date><risdate>2005</risdate><volume>25</volume><issue>3B</issue><spage>2027</spage><epage>2031</epage><pages>2027-2031</pages><issn>0250-7005</issn><eissn>1791-7530</eissn><abstract>Background: We report the prognostic significance of peripheral and tumor-infiltrating Th1, Th2, Tc1 and Tc2 cells in lung
cancer patients. Materials and Methods: We evaluated the rates of interferon (IFN)-γ+/CD4+ cells (Th1), interleukin (IL)-4+
/CD4+ cells (Th2), IFN-γ+/CD8+ cells (Tc1), IL-4+ /CD8+ cells (Tc2), and the ratio of Th1 to Th2 and that of Tc1 to Tc2 among
peripheral blood lymphocytes (PBL) and tumor-infiltrating lymphocytes (TIL), in 51 consecutive patients with non-small cell
lung cancer, by detecting the intracellular cytokine production using three-color flow cytometry. Results: Patients with a
low Th1/Th2 ratio in peripheral blood lymphocytes had a significantly better prognosis than those with a high Th1/Th2 ratio
(5-year survival rate: low: 74.7% vs. high: 50.3%; p=0.038). Patients with a low Th1/Th2 ratio in peripheral blood had a significantly
better prognosis than those with a high Th1/Th2 ratio in pathological Stage II or III (5-year survival rate: low: 66.6% vs.
high: 18.2%; p=0.018). Conclusion: A high Th1/Th2 ratio in peripheral blood is a negative prognostic factor, especially in
pathological Stage II or III non-small cell lung cancer patients.</abstract><cop>Attiki</cop><pub>International Institute of Anticancer Research</pub><pmid>16158940</pmid><tpages>5</tpages></addata></record> |
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| subjects | Aged Biological and medical sciences Carcinoma, Non-Small-Cell Lung - blood Carcinoma, Non-Small-Cell Lung - immunology Female Humans Lung Neoplasms - blood Lung Neoplasms - immunology Male Medical sciences Middle Aged Pneumology Prognosis T-Lymphocytes, Cytotoxic - immunology Th1 Cells - immunology Th2 Cells - immunology Tumors Tumors of the respiratory system and mediastinum |
| title | Prognostic Significance of T Helper 1 and 2 and T Cytotoxic 1 and 2 Cells in Patients with Non-small Cell Lung Cancer |
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