Brief Episode of Myocardial Ischemia Before Prolonged Ischemia Attenuates Cardiac Sympathetic Nerve Injury
Background The aim of this study was to investigate the effects of brief ischemia before prolonged ischemia on cardiac sympathetic neural function. Brief ischemia inhibits the sympathetic neural release of norepinephrine (NE) during subsequent sustained ischemia. However, whether it can attenuate th...
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| Veröffentlicht in: | Circulation Journal 2006, Vol.70(7), pp.919-925 |
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| creator | Nakadate, Teruo Nozawa, Takashi Matsuki, Akira Nonomura, Makoto Igarashi, Norio Igawa, Akihiko Inoue, Hiroshi |
| description | Background The aim of this study was to investigate the effects of brief ischemia before prolonged ischemia on cardiac sympathetic neural function. Brief ischemia inhibits the sympathetic neural release of norepinephrine (NE) during subsequent sustained ischemia. However, whether it can attenuate the neural function after sustained ischemia remains unknown. Methods and Results Sympathetic neural function was assessed using 123I-metaiodobenzylguanidine (MIBG) in patients who with (Group I) or without angina (Group II) within 3 days prior to acute myocardial infarction. In the rat experiment, cardiac interstitial NE (iNE) with or without pretreatment of 5-min coronary ligation was determined during a 30-min occlusion. Differences between MIBG and Thallium-201 for the total defect score were significantly greater in Group II than in Group I (6.1±4.0 vs 0.4±4.4). Levels of iNE were less in rats with a 5-min pretreatment (7.3±2.3 vs 18.6±5.9 ×103 pg/ml, p |
| doi_str_mv | 10.1253/circj.70.919 |
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Brief ischemia inhibits the sympathetic neural release of norepinephrine (NE) during subsequent sustained ischemia. However, whether it can attenuate the neural function after sustained ischemia remains unknown. Methods and Results Sympathetic neural function was assessed using 123I-metaiodobenzylguanidine (MIBG) in patients who with (Group I) or without angina (Group II) within 3 days prior to acute myocardial infarction. In the rat experiment, cardiac interstitial NE (iNE) with or without pretreatment of 5-min coronary ligation was determined during a 30-min occlusion. Differences between MIBG and Thallium-201 for the total defect score were significantly greater in Group II than in Group I (6.1±4.0 vs 0.4±4.4). Levels of iNE were less in rats with a 5-min pretreatment (7.3±2.3 vs 18.6±5.9 ×103 pg/ml, p<0.01) and MIBG uptake of ischemic region was greater (0.061±0.029 vs 0.031±0.011 %kg dose/g, p<0.05) compared with rats without the pretreatment. Conclusion A brief episode of ischemia attenuates the sympathetic neural injury caused by subsequent prolonged ischemia and this protective effect is associated with attenuation of NE release during the prolonged ischemia. (Circ J 2006; 70: 919 - 925)</description><identifier>ISSN: 1346-9843</identifier><identifier>EISSN: 1347-4820</identifier><identifier>DOI: 10.1253/circj.70.919</identifier><identifier>PMID: 16799249</identifier><language>eng</language><publisher>Japan: The Japanese Circulation Society</publisher><subject>3-Iodobenzylguanidine - administration & dosage ; Aged ; Angina Pectoris - complications ; Angina Pectoris - diagnostic imaging ; Angina Pectoris - metabolism ; Angina Pectoris - physiopathology ; Animals ; Arrhythmia ; Female ; Humans ; Male ; Middle Aged ; Myocardial infarction ; Myocardial Ischemia - diagnostic imaging ; Myocardial Ischemia - etiology ; Myocardial Ischemia - metabolism ; Myocardial Ischemia - physiopathology ; Nervous system ; Norepinephrine ; Norepinephrine - metabolism ; Nuclear medicine ; Radiography ; Radiopharmaceuticals - administration & dosage ; Rats ; Sympathetic Nervous System - diagnostic imaging ; Sympathetic Nervous System - injuries ; Sympathetic Nervous System - metabolism ; Sympathetic Nervous System - physiopathology ; Tomography, Emission-Computed, Single-Photon</subject><ispartof>Circulation Journal, 2006, Vol.70(7), pp.919-925</ispartof><rights>2006 THE JAPANESE CIRCULATION SOCIETY</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c576t-66374b9417a3417924c26824f802af1625d8731632a982979afd0c487077305b3</citedby><cites>FETCH-LOGICAL-c576t-66374b9417a3417924c26824f802af1625d8731632a982979afd0c487077305b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1882,4023,27922,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16799249$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nakadate, Teruo</creatorcontrib><creatorcontrib>Nozawa, Takashi</creatorcontrib><creatorcontrib>Matsuki, Akira</creatorcontrib><creatorcontrib>Nonomura, Makoto</creatorcontrib><creatorcontrib>Igarashi, Norio</creatorcontrib><creatorcontrib>Igawa, Akihiko</creatorcontrib><creatorcontrib>Inoue, Hiroshi</creatorcontrib><title>Brief Episode of Myocardial Ischemia Before Prolonged Ischemia Attenuates Cardiac Sympathetic Nerve Injury</title><title>Circulation Journal</title><addtitle>Circ J</addtitle><description>Background The aim of this study was to investigate the effects of brief ischemia before prolonged ischemia on cardiac sympathetic neural function. Brief ischemia inhibits the sympathetic neural release of norepinephrine (NE) during subsequent sustained ischemia. However, whether it can attenuate the neural function after sustained ischemia remains unknown. Methods and Results Sympathetic neural function was assessed using 123I-metaiodobenzylguanidine (MIBG) in patients who with (Group I) or without angina (Group II) within 3 days prior to acute myocardial infarction. In the rat experiment, cardiac interstitial NE (iNE) with or without pretreatment of 5-min coronary ligation was determined during a 30-min occlusion. Differences between MIBG and Thallium-201 for the total defect score were significantly greater in Group II than in Group I (6.1±4.0 vs 0.4±4.4). Levels of iNE were less in rats with a 5-min pretreatment (7.3±2.3 vs 18.6±5.9 ×103 pg/ml, p<0.01) and MIBG uptake of ischemic region was greater (0.061±0.029 vs 0.031±0.011 %kg dose/g, p<0.05) compared with rats without the pretreatment. Conclusion A brief episode of ischemia attenuates the sympathetic neural injury caused by subsequent prolonged ischemia and this protective effect is associated with attenuation of NE release during the prolonged ischemia. (Circ J 2006; 70: 919 - 925)</description><subject>3-Iodobenzylguanidine - administration & dosage</subject><subject>Aged</subject><subject>Angina Pectoris - complications</subject><subject>Angina Pectoris - diagnostic imaging</subject><subject>Angina Pectoris - metabolism</subject><subject>Angina Pectoris - physiopathology</subject><subject>Animals</subject><subject>Arrhythmia</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Myocardial infarction</subject><subject>Myocardial Ischemia - diagnostic imaging</subject><subject>Myocardial Ischemia - etiology</subject><subject>Myocardial Ischemia - metabolism</subject><subject>Myocardial Ischemia - physiopathology</subject><subject>Nervous system</subject><subject>Norepinephrine</subject><subject>Norepinephrine - metabolism</subject><subject>Nuclear medicine</subject><subject>Radiography</subject><subject>Radiopharmaceuticals - administration & dosage</subject><subject>Rats</subject><subject>Sympathetic Nervous System - diagnostic imaging</subject><subject>Sympathetic Nervous System - injuries</subject><subject>Sympathetic Nervous System - metabolism</subject><subject>Sympathetic Nervous System - physiopathology</subject><subject>Tomography, Emission-Computed, Single-Photon</subject><issn>1346-9843</issn><issn>1347-4820</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkElPwzAQRi0EYincOCOfOJHiJbHjY6lYKrFJwNlynUmbKImLnSD132Pail5mRpo3n0YPoUtKxpRl_NZW3tZjScaKqgN0SnkqkzRn5HAzi0TlKT9BZyHUhDBFMnWMTqiQSrFUnaL6zldQ4vtVFVwB2JX4Ze2s8UVlGjwLdgltZfAdlM4Dfveucd0Civ1m0vfQDaaHgKebK4s_1u3K9EvoK4tfwf8AnnX14Nfn6Kg0TYCLXR-hr4f7z-lT8vz2OJtOnhObSdEnQnCZzlVKpeGxxDctEzlLy5wwU1LBsiKXnArOjMqZksqUBbFpLomUnGRzPkLX29yVd98DhF63VbDQNKYDNwQt8izeMxXBmy1ovQvBQ6lXvmqNX2tK9J9bvXGrJdHRbcSvdrnDvIViD-9kRmCyBerQmwX8A8ZHFQ3s0-S2xND9bmm8ho7_Ahf4jIc</recordid><startdate>2006</startdate><enddate>2006</enddate><creator>Nakadate, Teruo</creator><creator>Nozawa, Takashi</creator><creator>Matsuki, Akira</creator><creator>Nonomura, Makoto</creator><creator>Igarashi, Norio</creator><creator>Igawa, Akihiko</creator><creator>Inoue, Hiroshi</creator><general>The Japanese Circulation Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2006</creationdate><title>Brief Episode of Myocardial Ischemia Before Prolonged Ischemia Attenuates Cardiac Sympathetic Nerve Injury</title><author>Nakadate, Teruo ; Nozawa, Takashi ; Matsuki, Akira ; Nonomura, Makoto ; Igarashi, Norio ; Igawa, Akihiko ; Inoue, Hiroshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c576t-66374b9417a3417924c26824f802af1625d8731632a982979afd0c487077305b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>3-Iodobenzylguanidine - administration & dosage</topic><topic>Aged</topic><topic>Angina Pectoris - complications</topic><topic>Angina Pectoris - diagnostic imaging</topic><topic>Angina Pectoris - metabolism</topic><topic>Angina Pectoris - physiopathology</topic><topic>Animals</topic><topic>Arrhythmia</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Myocardial infarction</topic><topic>Myocardial Ischemia - diagnostic imaging</topic><topic>Myocardial Ischemia - etiology</topic><topic>Myocardial Ischemia - metabolism</topic><topic>Myocardial Ischemia - physiopathology</topic><topic>Nervous system</topic><topic>Norepinephrine</topic><topic>Norepinephrine - metabolism</topic><topic>Nuclear medicine</topic><topic>Radiography</topic><topic>Radiopharmaceuticals - administration & dosage</topic><topic>Rats</topic><topic>Sympathetic Nervous System - diagnostic imaging</topic><topic>Sympathetic Nervous System - injuries</topic><topic>Sympathetic Nervous System - metabolism</topic><topic>Sympathetic Nervous System - physiopathology</topic><topic>Tomography, Emission-Computed, Single-Photon</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nakadate, Teruo</creatorcontrib><creatorcontrib>Nozawa, Takashi</creatorcontrib><creatorcontrib>Matsuki, Akira</creatorcontrib><creatorcontrib>Nonomura, Makoto</creatorcontrib><creatorcontrib>Igarashi, Norio</creatorcontrib><creatorcontrib>Igawa, Akihiko</creatorcontrib><creatorcontrib>Inoue, Hiroshi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation Journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nakadate, Teruo</au><au>Nozawa, Takashi</au><au>Matsuki, Akira</au><au>Nonomura, Makoto</au><au>Igarashi, Norio</au><au>Igawa, Akihiko</au><au>Inoue, Hiroshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Brief Episode of Myocardial Ischemia Before Prolonged Ischemia Attenuates Cardiac Sympathetic Nerve Injury</atitle><jtitle>Circulation Journal</jtitle><addtitle>Circ J</addtitle><date>2006</date><risdate>2006</risdate><volume>70</volume><issue>7</issue><spage>919</spage><epage>925</epage><pages>919-925</pages><issn>1346-9843</issn><eissn>1347-4820</eissn><abstract>Background The aim of this study was to investigate the effects of brief ischemia before prolonged ischemia on cardiac sympathetic neural function. Brief ischemia inhibits the sympathetic neural release of norepinephrine (NE) during subsequent sustained ischemia. However, whether it can attenuate the neural function after sustained ischemia remains unknown. Methods and Results Sympathetic neural function was assessed using 123I-metaiodobenzylguanidine (MIBG) in patients who with (Group I) or without angina (Group II) within 3 days prior to acute myocardial infarction. In the rat experiment, cardiac interstitial NE (iNE) with or without pretreatment of 5-min coronary ligation was determined during a 30-min occlusion. Differences between MIBG and Thallium-201 for the total defect score were significantly greater in Group II than in Group I (6.1±4.0 vs 0.4±4.4). Levels of iNE were less in rats with a 5-min pretreatment (7.3±2.3 vs 18.6±5.9 ×103 pg/ml, p<0.01) and MIBG uptake of ischemic region was greater (0.061±0.029 vs 0.031±0.011 %kg dose/g, p<0.05) compared with rats without the pretreatment. Conclusion A brief episode of ischemia attenuates the sympathetic neural injury caused by subsequent prolonged ischemia and this protective effect is associated with attenuation of NE release during the prolonged ischemia. (Circ J 2006; 70: 919 - 925)</abstract><cop>Japan</cop><pub>The Japanese Circulation Society</pub><pmid>16799249</pmid><doi>10.1253/circj.70.919</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 3-Iodobenzylguanidine - administration & dosage Aged Angina Pectoris - complications Angina Pectoris - diagnostic imaging Angina Pectoris - metabolism Angina Pectoris - physiopathology Animals Arrhythmia Female Humans Male Middle Aged Myocardial infarction Myocardial Ischemia - diagnostic imaging Myocardial Ischemia - etiology Myocardial Ischemia - metabolism Myocardial Ischemia - physiopathology Nervous system Norepinephrine Norepinephrine - metabolism Nuclear medicine Radiography Radiopharmaceuticals - administration & dosage Rats Sympathetic Nervous System - diagnostic imaging Sympathetic Nervous System - injuries Sympathetic Nervous System - metabolism Sympathetic Nervous System - physiopathology Tomography, Emission-Computed, Single-Photon |
| title | Brief Episode of Myocardial Ischemia Before Prolonged Ischemia Attenuates Cardiac Sympathetic Nerve Injury |
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